Navigation Links
4 genes indentified that influence levels of 'bad' cholesterol
Date:5/15/2013

Scientists at the Texas Biomedical Research Institute in San Antonio have identified four genes in baboons that influence levels of "bad" cholesterol. This discovery could lead to the development of new drugs to reduce the risk of heart disease.

"Our findings are important because they provide new targets for the development of novel drugs to reduce heart disease risk in humans," said Laura Cox, Ph.D., a Texas Biomed geneticist. "Since these genes have previously been associated with cancer, our findings suggest that genetic causes of heart disease may overlap with causes of some types of cancer." The new study, funded by the National Institutes of Health (NIH), is published online and will appear in the July print issue of the Journal of Lipid Research. It can be found at: http://www.jlr.org/content/early/2013/05/06/jlr.M032649.full.pdf+html.

Texas Biomed scientists screened their baboon colony of 1,500 animals to find three half-siblings with low levels of low density lipoprotein (LDL), or "bad,"' cholesterol, and three half-siblings with high levels of LDL. In the study, these animals were fed a high-cholesterol, high-fat diet for seven weeks. Scientists then used gene array technology and high throughput sequencers to home in on the genes expressed in the two groups and differentiate those in the low LDL groups from those in the high LDL group. They discovered that four genes (named TENC1, ERBB3, ACVR1B, and DGKA) influence LDL levels. Interestingly, these four genes are part of a signaling pathway important for cell survival and disruption of this pathway promotes some types of cancer.

It is well-known that a high level of LDL is a major risk factor for heart disease. Despite concerted efforts for the past 25 years to manage cholesterol levels through changes in lifestyle and treatment with medications, heart disease remains the leading cause of death and mortality in the United States and around the world. It will account for one out of four U.S. deaths in 2013, according to the American Heart Association.

Heart disease is a complex disorder thought to be a result of interactions between genetic and environmental factors, which occur primarily through diet. To understand why humans have different levels of LDL and thus variation in risk for heart disease, the genetic factors causing these differences need to be understood.

However, these studies are difficult to do in humans because it's practically impossible to control what people eat. Instead, Texas Biomed scientists are using baboons, which are similar to humans in their physiology and genetics, to identify genes that influence heart disease risk.

The new research also suggests that knowing many of the genes responsible for heart disease may be necessary to devise effective treatments. For example, several genes may need to be targeted at once to control risk.

The next step in this research is to find the mechanism by which these genes influence LDL cholesterol. "That starts to give us the specific targets for new therapies." Cox said. If all goes well, this information may be available within two years.


'/>"/>

Contact: Joseph Carey
jcarey@txbiomed.org
210-258-9437
Texas Biomedical Research Institute
Source:Eurekalert

Related biology news :

1. Study: MicroRNA cooperation mutes breast cancer oncogenes
2. AACR news: Misregulated genes common to tobacco-related cancers offer potential new prognostic tool
3. CSHL neuroscientists show jumping genes may contribute to aging-related brain defects
4. Genes behind obesity mapped in large-scale study
5. Finding genes for childhood obesity
6. New insights into how genes turn on and off
7. Appetite genes are key to better diets for poultry, study shows
8. Genes may be reason some kids are picky about food
9. Researchers create map of shortcuts between all human genes
10. Sleator lab identifies single point mutation in Listeria monocytogenes
11. March of Dimes awards $250,000 to researcher who identified heart disease genes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... PALM BEACH GARDENS, Fla. , April 11, ... biometric identity management and secure authentication solutions, today ... million contract by Intelligence Advanced Research Projects Activity ... technologies for IARPA,s Thor program. "Innovation ... the onset and IARPA,s Thor program will allow ...
(Date:4/6/2017)... , April 6, 2017 Forecasts ... ANPR, Document Readers, by End-Use (Transportation & Logistics, Government ... Oil, Gas & Fossil Generation Facility, Nuclear Power), Industrial, ... Other) Are you looking for a definitive ... ...
(Date:4/4/2017)... 2017   EyeLock LLC , a leader of ... States Patent and Trademark Office (USPTO) has issued U.S. ... of an iris image with a face image acquired ... company,s 45 th issued patent. ... given the multi-modal biometric capabilities that have recently come ...
Breaking Biology News(10 mins):
(Date:5/19/2017)... ... May 19, 2017 , ... The University ... researchers with technologies ripe for commercialization, and who are affiliated with the 21 ... to submit proposals. QED, now in its tenth round, is the first multi-institutional ...
(Date:5/18/2017)... ... May 17, 2017 , ... NDA Partners Chairman Carl Peck, ... of Eurofins Advantar Laboratories and President of Pharmaceutical Development Business Unit of Cardinal Health, ... Eurofins and Cardinal Health, he was former Chief Operating Officer at Anaborex, Senior VP ...
(Date:5/18/2017)... ... May 17, 2017 , ... HOLLOWAY AMERICA, ... including food and dairy, munitions, and pharmaceutical/biotech, recently introduced The Revolution Lift™, a ... use. The improvement in technology comes on the heels of HOLLOWAY’s release of ...
(Date:5/16/2017)... ... May 16, 2017 , ... Genedata, ... Genedata Screener User Group Meetings, which will be held in Boston, ... share best practices in screening data analysis and learn about the latest advances ...
Breaking Biology Technology: