Navigation Links
4 days of REM sleep deprivation contributes to a reduction of cell proliferation in rats
Date:2/1/2008

WESTCHESTER, Ill. Four days exposure to a REM sleep deprivation procedure reduces cell proliferation in the part of the forebrain that contributes to long-term memory of rats, according to a study published in the February 1 issue of the journal SLEEP.

The study, authored by Dennis McGinty, PhD, of the V.A. Greater Los Angeles Healthcare System, focused on male Sprague-Dawley rats. REM sleep deprivation was achieved by a brief treadmill movement initiated by automatic online detection of REM sleep. A yoked-control (YC) rat was placed in the same treadmill and experienced the identical movement regardless of the stage of the sleep-wake cycle.

According to the results, REM sleep was reduced by 85 percent in REM sleep deprived rats and by 43 percent in YC rats. Cell proliferation was reduced by 63 percent in REM sleep deprived rats compared with YC rats. Across all animals, cell proliferation exhibited a positive correlation with the percentage of REM sleep.

Several studies have shown that sleep contributes to brain plasticity in general, and to adult neurogenesis, in particular, said Dr. McGinty. Neurogenesis is a concrete example of brain plasticity, suppression of adult neurogenesis is thought to be important in pathologies such as depression. One current question has to do with the relative contribution of the two sleep states, non-REM and REM, which have very different, even opposite, physiological properties. This study showed that REM sleep has a critical role in facilitating brain plasticity. The study does not exclude an equally important role for non-REM sleep. In other recent work, we have shown that sleep fragmentation can also suppress adult neurogenesis. How sleep affects the molecular mechanisms underlying neurogenesis remains to be explored.

It is recommended that older adults get between seven and eight hours of nightly sleep.

The American Academy of Sleep Medicine (AASM) offers the following tips on how to get a good nights sleep:

  • Follow a consistent bedtime routine.

  • Establish a relaxing setting at bedtime.

  • Get a full nights sleep every night.

  • Avoid foods or drinks that contain caffeine, as well as any medicine that has a stimulant, prior to bedtime.

  • Do not bring your worries to bed with you.

  • Do not go to bed hungry, but dont eat a big meal before bedtime either.

  • Avoid any rigorous exercise within six hours of your bedtime.

  • Make your bedroom quiet, dark and a little bit cool.

  • Get up at the same time every morning.


'/>"/>

Contact: Jim Arcuri
jarcuri@aasmnet.org
708-492-0930
American Academy of Sleep Medicine
Source:Eurekalert

Related biology news :

1. Alcohol and sleep restriction can affect young mens alertness and driving performance
2. Ohio scientists develop blue-blocking glasses to improve sleep and ADHD symptoms
3. Journal Sleep: Insomniacs are more likely to report a family history of the sleep disorder
4. Snoozing worms help Penn researchers explain the evolution of sleep
5. KGI professor contributes new insights on jumping genes
6. Mayo Clinic study: Ossurs collars superior in immobilization and reduction of pressure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/9/2016)... , March 9, 2016 This BCC ... future states of the RNA Sequencing (RNA Seq) market ... such as instruments, tools and reagents, data analysis, and ... various segments of the RNA-Sequencing market such as RNA-Sequencing ... Identify the main factors affecting each segment and forecast ...
(Date:3/9/2016)... March 9, 2016  Crossmatch ® , a ... solutions, today announced the addition of smart features ... multi-factor authentication platform. New contextual and application-specific ... step-up security where it,s needed most — while ... DC . --> Washington, ...
(Date:3/3/2016)... -- FlexTech, a SEMI Strategic Association Partner, awarded five FLEXI ... Leadership in Education, and, in a category new this ... year of the FLEXI Awards and the winners join ... past years . Judging was done on a set ... by a panel of non-affiliated, independent, industry experts. ...
Breaking Biology News(10 mins):
(Date:4/27/2016)... ... April 27, 2016 , ... ... has joined the company as an Expert Consultant. Mr. Clark was formerly ... and managing the development of small molecule monographs based on analytical methods. ...
(Date:4/27/2016)... ... ... Global Stem Cells Group and the University of Santiago Biotechnology Lab have ... for potential stem cell protocol management for 2016 – 2020. , In 2015, ... establish a working agenda and foster initiatives to promote stem cell research and development ...
(Date:4/26/2016)... Redwood City, CA (PRWEB) , ... April 26, ... ... company for healthcare, today announced that Ardy Arianpour has joined the company as ... 14 years of experience bringing innovative genomic technologies to market, was most recently ...
(Date:4/26/2016)... ... ... This unique "Fertility Happy Hour" event will be held at The Saguaro Hotel ... on female fertility and the reproductive technologies that are empowering a new generation of ... The Arizona Center, will give a short presentation and answer questions about age ...
Breaking Biology Technology: