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4-D software helps adjust for breathing when treating lung cancer with radiotherapy
Date:4/30/2010

echnique involves two steps: first, for each patient, a 4-dimensional computed tomography (4D CT) scan is performed, recording a set of CT slices for each of 10 respiratory phases. This technique is already well known in the medical world, particularly in the field of cardiology.

Second, the new software helps the radiation oncologist to determine if there is a respiratory phase that is most convenient for radiotherapy, based on criteria that have been established by a panel of oncologists.

"The software doesn't require any special equipment and doesn't cause any additional cost," Dr Peguret said. "However, it is important to have a 4D CT available to be able to acquire synchronized image sets, as well as a system that allows synchronization of the thoracic movements during radiotherapy."

"The software will never replace the radiation oncologist," he added. "It simply provides the doctor with information about the movement of the tumor. Depending on the oncologist's clinical objectives, he or she will choose the optimal phase for radiotherapy in an individual patient. In this way, our software transforms the information provided by 4D CT into a real benefit for the patient."

At the conference, Dr Peguret will report that the system may help to increase the dose to the target. "Local control and overall survival depend on the radiation dose that can be delivered to the tumor with a relative sparing of the organs at risk," he said.

"To our knowledge, there is no other similar software on the market. 4D CT and the techniques of BART are still underutilized in oncology. This work might allow its dispersion to other centers with the ultimate aim of improving the survival of the patients."

A Phase II clinical trial is currently underway and results are expected early in 2011.


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Contact: Vanessa Pavinato
media@esmo.org
European Society for Medical Oncology
Source:Eurekalert

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