Navigation Links
4-D software helps adjust for breathing when treating lung cancer with radiotherapy
Date:4/30/2010

A new 4-dimensional software program promises to improve the treatment of lung cancer by allowing doctors to take the movement of breathing into account when administering radiotherapy, researchers announced today at the 2nd European Lung Cancer Conference in Geneva, Switzerland.

Some lung tumors shift their position as patients inhale and exhale. The amount of movement depends on where they are in the lung. For example, lesions in the lower lobes may move up to 4 cm.

This movement poses a challenge for doctors treating the cancer with radiotherapy. If they use too small an irradiation field, the tumor can move so far that it is missed by the treatment. To avoid this, standard radiotherapy uses large radiation fields to take into account the respiratory movements, but in doing so can damage large areas of healthy lung tissue.

A newer approach, called 'breathing-adapted radiotherapy' (BART) allows doctors to reduce the amount of radiation delivered, and improve the chance of hitting the tumor, by timing delivery to a particular moment of the respiratory cycle.

"One of the main problems with BART is how to choose the optimal respiratory phase in which to treat the patient," explains Dr Nicolas Peguret from Hpitau Universitaires de Genve. "This phase is basically unknown and may be in deep inspiration, in expiration or even in a third respiratory phase somewhere between. It may vary from one patient to another because of the variation in tumor localization and in movements of the tumor and of other nearby organs."

Dr Peguret and colleagues have developed software which allows doctors to determine a moment during the respiratory cycle with an optimal tumor position for radiotherapy. "By applying this software together with BART, it may be possible not only to reduce the radiation fields but also to adapt the radiation volume taking into account the varying positions of the tumor and the organs at risk."

The technique involves two steps: first, for each patient, a 4-dimensional computed tomography (4D CT) scan is performed, recording a set of CT slices for each of 10 respiratory phases. This technique is already well known in the medical world, particularly in the field of cardiology.

Second, the new software helps the radiation oncologist to determine if there is a respiratory phase that is most convenient for radiotherapy, based on criteria that have been established by a panel of oncologists.

"The software doesn't require any special equipment and doesn't cause any additional cost," Dr Peguret said. "However, it is important to have a 4D CT available to be able to acquire synchronized image sets, as well as a system that allows synchronization of the thoracic movements during radiotherapy."

"The software will never replace the radiation oncologist," he added. "It simply provides the doctor with information about the movement of the tumor. Depending on the oncologist's clinical objectives, he or she will choose the optimal phase for radiotherapy in an individual patient. In this way, our software transforms the information provided by 4D CT into a real benefit for the patient."

At the conference, Dr Peguret will report that the system may help to increase the dose to the target. "Local control and overall survival depend on the radiation dose that can be delivered to the tumor with a relative sparing of the organs at risk," he said.

"To our knowledge, there is no other similar software on the market. 4D CT and the techniques of BART are still underutilized in oncology. This work might allow its dispersion to other centers with the ultimate aim of improving the survival of the patients."

A Phase II clinical trial is currently underway and results are expected early in 2011.


'/>"/>

Contact: Vanessa Pavinato
media@esmo.org
European Society for Medical Oncology
Source:Eurekalert

Related biology news :

1. TransPerfect Acquires Astoria Software
2. Aware Biometrics Software Provided for Advanced Technology Workstations
3. Dog bites research: UAB testing software to teach kids, dogs to interact safely
4. UWM researcher predicts stem cell fate with software
5. City of Winter Park Looks to DigitalPersona Software for Stronger Security and CJIS Compliance
6. BIO-key(R) Launches TruDonor ID(TM), the First SaaS (Software as a Service) Biometric Identification Solution
7. Glencoe Software to Support the ASCB Stimulus Grant to Build Virtual Image Library of the Cell
8. Improved Endo Capsule Software enhances diagnostic experience
9. Aware Software and Development Services Enable State-of-the-Art Fingerprint Card Scanning
10. Leading Fingerprint Software Chosen to Enroll and Verify Pilgrims at Hajj by the Kaduna State Muslims Pilgrims Board in Nigeria
11. M2SYS Biometric Software Solution Selected By GHG Corporation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/22/2016)... On Monday, the Department of Homeland Security (DHS) issued ... the Biometric Exit Program. The Request for Information (RFI), ... that CBP intends to add biometrics to confirm when ... , in order to deter visa overstays, to ... Logo - http://photos.prnewswire.com/prnh/20160622/382209LOGO ...
(Date:6/16/2016)... 16, 2016 The global ... to reach USD 1.83 billion by 2024, according ... Inc. Technological proliferation and increasing demand in commercial ... to drive the market growth.      ... The development of advanced multimodal techniques for biometric ...
(Date:6/9/2016)... -- Paris Police Prefecture ... to ensure the safety of people and operations in several ... tournament Teleste, an international technology group specialised in ... that its video security solution will be utilised by ... safety across the country. The system roll-out is scheduled for ...
Breaking Biology News(10 mins):
(Date:12/7/2016)... Dec. 7, 2016  Genprex, Inc. a biopharmaceutical ... therapy treatments, today announced that it has retained ... leading strategic communications and advisory firm, to develop ... program will combine investor relations, public relations and ... the profile of Genprex and its lead candidate ...
(Date:12/7/2016)... (PRWEB) , ... December 07, 2016 , ... ... digital pathology, announced today a new service to enable rapid migration of large ... upload has remained one of the factors limiting adoption of digital pathology. Proscia’s ...
(Date:12/6/2016)... 6, 2016 /PRNewswire/ - SQI Diagnostics Inc. ("SQI" or the "Company") (TSX-V: ... fourth quarter and fiscal year ended September 30, 2016. ... , , ... sciences and diagnostics company that develops and commercializes proprietary technologies and ... Achieved revenues of $1.4 million more than tripling prior ...
(Date:12/6/2016)... ... December 06, 2016 , ... ... platforms, announced today that the company has engaged in a collaborative research partnership ... (MRDA) with the CSU Office of the Vice President for Research. This agreement ...
Breaking Biology Technology: