Navigation Links
4-D software helps adjust for breathing when treating lung cancer with radiotherapy
Date:4/30/2010

A new 4-dimensional software program promises to improve the treatment of lung cancer by allowing doctors to take the movement of breathing into account when administering radiotherapy, researchers announced today at the 2nd European Lung Cancer Conference in Geneva, Switzerland.

Some lung tumors shift their position as patients inhale and exhale. The amount of movement depends on where they are in the lung. For example, lesions in the lower lobes may move up to 4 cm.

This movement poses a challenge for doctors treating the cancer with radiotherapy. If they use too small an irradiation field, the tumor can move so far that it is missed by the treatment. To avoid this, standard radiotherapy uses large radiation fields to take into account the respiratory movements, but in doing so can damage large areas of healthy lung tissue.

A newer approach, called 'breathing-adapted radiotherapy' (BART) allows doctors to reduce the amount of radiation delivered, and improve the chance of hitting the tumor, by timing delivery to a particular moment of the respiratory cycle.

"One of the main problems with BART is how to choose the optimal respiratory phase in which to treat the patient," explains Dr Nicolas Peguret from Hpitau Universitaires de Genve. "This phase is basically unknown and may be in deep inspiration, in expiration or even in a third respiratory phase somewhere between. It may vary from one patient to another because of the variation in tumor localization and in movements of the tumor and of other nearby organs."

Dr Peguret and colleagues have developed software which allows doctors to determine a moment during the respiratory cycle with an optimal tumor position for radiotherapy. "By applying this software together with BART, it may be possible not only to reduce the radiation fields but also to adapt the radiation volume taking into account the varying positions of the tumor and the organs at risk."

The technique involves two steps: first, for each patient, a 4-dimensional computed tomography (4D CT) scan is performed, recording a set of CT slices for each of 10 respiratory phases. This technique is already well known in the medical world, particularly in the field of cardiology.

Second, the new software helps the radiation oncologist to determine if there is a respiratory phase that is most convenient for radiotherapy, based on criteria that have been established by a panel of oncologists.

"The software doesn't require any special equipment and doesn't cause any additional cost," Dr Peguret said. "However, it is important to have a 4D CT available to be able to acquire synchronized image sets, as well as a system that allows synchronization of the thoracic movements during radiotherapy."

"The software will never replace the radiation oncologist," he added. "It simply provides the doctor with information about the movement of the tumor. Depending on the oncologist's clinical objectives, he or she will choose the optimal phase for radiotherapy in an individual patient. In this way, our software transforms the information provided by 4D CT into a real benefit for the patient."

At the conference, Dr Peguret will report that the system may help to increase the dose to the target. "Local control and overall survival depend on the radiation dose that can be delivered to the tumor with a relative sparing of the organs at risk," he said.

"To our knowledge, there is no other similar software on the market. 4D CT and the techniques of BART are still underutilized in oncology. This work might allow its dispersion to other centers with the ultimate aim of improving the survival of the patients."

A Phase II clinical trial is currently underway and results are expected early in 2011.


'/>"/>

Contact: Vanessa Pavinato
media@esmo.org
European Society for Medical Oncology
Source:Eurekalert

Related biology news :

1. TransPerfect Acquires Astoria Software
2. Aware Biometrics Software Provided for Advanced Technology Workstations
3. Dog bites research: UAB testing software to teach kids, dogs to interact safely
4. UWM researcher predicts stem cell fate with software
5. City of Winter Park Looks to DigitalPersona Software for Stronger Security and CJIS Compliance
6. BIO-key(R) Launches TruDonor ID(TM), the First SaaS (Software as a Service) Biometric Identification Solution
7. Glencoe Software to Support the ASCB Stimulus Grant to Build Virtual Image Library of the Cell
8. Improved Endo Capsule Software enhances diagnostic experience
9. Aware Software and Development Services Enable State-of-the-Art Fingerprint Card Scanning
10. Leading Fingerprint Software Chosen to Enroll and Verify Pilgrims at Hajj by the Kaduna State Muslims Pilgrims Board in Nigeria
11. M2SYS Biometric Software Solution Selected By GHG Corporation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2017)... Report Highlights The global biosurgery market should ... 2016 at a compound annual growth rate (CAGR) of ... An overview of the global market for biosurgery. - ... and 2016, and projections of compound annual growth rates ... the basis of product type, source, application, and region. ...
(Date:2/6/2017)... , Feb. 6, 2017 According to ... are driving border authorities to continue to embrace ... there are 2143 Automated Border Control (ABC) eGates ... deployed at more than 163 ports of entry ... to 2016 achieving a combined CAGR of 37%. ...
(Date:2/2/2017)... Feb. 2, 2017  EyeLock LLC, a market leader ... white paper " What You Should Know About Biometrics ... ensuring user authenticity is a growing concern. In traditional ... users. However, traditional authentication schemes such as username/password suffer ... Biometric authentication offers an elegant solution to the problem ...
Breaking Biology News(10 mins):
(Date:2/23/2017)... ... 2017 , ... BellBrook Labs is formalizing a significant expansion ... biochemical analyses critical for Lead Discovery. The company’s Lead Discovery Services will ... inhibitor potency and selectivity, mechanism of action, and inhibitor residence times on drug ...
(Date:2/23/2017)... , Feb. 23, 2017  In Atlanta, it seems everyone ... and culture intertwine to create an expressive and dynamic community ... this energy and contribute to it. With ... Hair Fairies seeks to carry on that tradition with ... Atlanta salon is the newest of 13 ...
(Date:2/23/2017)... ... February 23, 2017 , ... Brain Sentinel, Inc. ... marketing the SPEAC® System, the Brain Sentinel® Seizure Monitoring and Alerting System. The ... facilities during periods of rest. A lightweight, non-invasive monitor is placed on the ...
(Date:2/23/2017)... ... 23, 2017 , ... Today, researchers can fast-track sample collection ... and/or other biomarkers or SNPs of interest) using one, easy-to-collect saliva sample. With ... relationship between insulin and other relevant biomarkers can be extensively studied through a ...
Breaking Biology Technology: