Navigation Links
3D microgels 'on-demand' offer new potential for cell research
Date:2/26/2014

on the top plate of the system, made from indium in oxide, and become fixed.

"When we grew kidney cells in these microgels, the cultures formed hollow sphere structures resembling primitive kidneys within four or five days," Eydelnant claims.

The tool allows a great deal of flexibility in terms of the number of different kinds of cells that can be incorporated into the shapes, as well as the shapes and size of the microenvironments: whimsical, like the stars, diamond and circles of Lucky Charms, or designed to mimic living 3D niches, offering researchers a glimpse into how these factors all affect cell fate decisions.

What's more, according to Eydelnant, the platform permits researchers to run, "32 experiments at the same time, automatically, and all on something the size of a credit card."

"[This new] system allows for hands-free assembly of sub-microlitre, three-dimensional microgels. Each gel is individually addressable, fluid exchange is gentler than macro-scale alternatives, and reagent use is reduced more than 100-fold," Wheeler says.

"We believe that this new tool will make 3D cell culture a more attractive and accessible format for cell biology research," he adds.

Although the researchers can foresee numerous possible applications for this platform, the team is "particularly excited" about its potential for personalized medicine.

Wheeler argues, "We may be able to collect small tissue samples from patients, distribute them into 3D gels on digital microfluidic devices, and screen for conditions to identify individually tailored therapies. This is in the 'dream' stages for now, but we think the methods described here will be useful for these types of applications in the future."


'/>"/>

Contact: Erin Vollick
comm.ibbme@utoronto.ca
416-946-8019
University of Toronto
Source:Eurekalert

Page: 1 2

Related biology news :

1. Osteoarthritis medicine delivered on-demand
2. Mercy Lab Offers Faster On-demand Diabetes Testing, Cellular Studies
3. New biological scaffold offers promising foundation for engineered tissues
4. Paper offers insights into network that plays crucial role in cell function and disease
5. Genetic function discovered that could offer new avenue to cancer therapies
6. Space flies offer clues about microgravitys impact on astronauts
7. Natural engineering offers solution against future flooding
8. Scripps Florida scientists offer new insight into neuron changes brought about by aging
9. 2014 ASMCUE and ASM General Meeting collaborate to offer the latest in teaching and research
10. Study offers clues to how plants evolved to cope with cold
11. Blind cavefish offer evidence for alternative mechanism of evolutionary change
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... 2014 Amyloid diseases, such as Alzheimer,s disease, ... all share the common trait that proteins aggregate ... in vitro studies have found that neither the ... very toxic. New evidence using two-dimensional infrared (2D ... the amylin aggregation pathway that may explain toxicity, ...
(Date:7/10/2014)... (July 10, 2014) New research from The University ... that It,s Your GameKeep it Real (IYG), a health ... healthy dating relationships, can significantly reduce dating violence behaviors ... Disease Control and Prevention, 10 percent of high school ... studies suggest that more than 20 percent are victims ...
(Date:7/10/2014)... NOAA and its research partners predict that western Lake ... toxic blue-green algae, during the 2014 bloom season in ... be smaller than last year,s intense bloom, and considerably ... will vary across the lake,s western basin and are ... how far it spreads. , Harmful algal blooms ...
Breaking Biology News(10 mins):New technology reveals insights into mechanisms underlying amyloid diseases 2It's Your Game ... Keep It Real reduces dating violence among minority youth 2NOAA, partners predict significant harmful algal bloom in western Lake Erie this summer 2NOAA, partners predict significant harmful algal bloom in western Lake Erie this summer 3
... MABrown seems to be the color of choice when it comes to ... while its counterpart, white fat stores it. The danger in white fat ... poses, seems especially linked to visceral fat. Visceral fat is the build-up ... in the battle against obesity, brown fat appears to be our friend ...
... This release is available in German . ... plant species develop special strategies. These differ in part considerably ... Ingolf Khn and Dr. Sonja Knapp of the Helmholtz Centre ... published in the current issue of the scientific journal ...
... NOAA scientists and their colleagues have discovered a biological ... mammals that shows when they have been repeatedly exposed ... toxic at high levels. While little is ... marine animals or humans, high-level exposure through eating contaminated ...
Cached Biology News:A new candidate pathway for treating visceral obesity 2Different recipes for success in the world of plants 2Different recipes for success in the world of plants 3NOAA discovers way to detect low-level exposure to seafood toxin in marine animals 2
(Date:7/10/2014)... 17, 2014 Using microscopic polymer light resonators ... researchers at MIT,s Quantum Photonics Laboratory have developed ... the parts-per-billion range. Optical sensors are ideal for ... signal-to-noise ratio, compact, lightweight nature, and immunity to ... had been developed before, the MIT team conceived ...
(Date:7/10/2014)... observed the fractional quantum Hall effect in bilayer graphene ... be tuned by an electric field. , The ... confined to thin sheets are exposed to large magnetic ... thousands of individual electrons behave as a single system. ... well established, many details of this collective behavior remain ...
(Date:7/10/2014)... have shelled out for crude 3-D glasses, polarized ... experience. These basic devices, used to trick the ... soon be rendered obsolete with the introduction of ... researchers. , TAU doctoral students Yuval Yifat, Michal ... holography based on nanoantennas that could be used ...
(Date:1/15/2014)... an approach akin to assembling a club sandwich ... Technology (NIST) researchers have succeeded in crafting a ... flammability of foam commonly used in upholstered furniture ... the nanotube-coated polyurethane foam was reduced 35 percent ...
Breaking Biology Technology:Swell new sensors 2Columbia researchers observe tunable quantum behavior in bilayer graphene 2Columbia researchers observe tunable quantum behavior in bilayer graphene 3Projecting a 3-dimensional future 2Projecting a 3-dimensional future 3Layered security: Carbon nanotubes promise improved flame-resistant coating 2
... 28 Cylene Pharmaceuticals has appointed,Dr. Kenna Anderes ... 17 years,of life sciences research experience with a ... President of Cancer Biology. With Cylene,s,most advanced compound, ... will be leading Cylene,s biology and pre-clinical research,teams ...
... - Oncothyreon Inc. (the,"Company") (Nasdaq: ONTY ) ... innovative therapeutic products for the treatment of,cancer, today ... plans,and corporate objectives for 2008. Oncothyreon is developing ... the potential to,improve the lives and outcomes of ...
... MNKD ), focused on discovering, developing and,commercializing treatments ... at the Wachovia Healthcare Conference on January 30, 2008 ... MA., Interested parties can access a link to ... Relations section of the Company,s website at, http://www.mannkindcorp.com . ...
Cached Biology Technology:Cylene Pharmaceuticals Appoints Kenna Anderes, Ph.D. as Vice President of Cancer Biology 2Oncothyreon highlights corporate and clinical objectives for 2008 2Oncothyreon highlights corporate and clinical objectives for 2008 3Oncothyreon highlights corporate and clinical objectives for 2008 4Oncothyreon highlights corporate and clinical objectives for 2008 5
Monoclonal antibodies conjugated with rhodamine...
... p- methoxyhydrocinnamamido)-3′-deoxy-N,N-dimethyladenosine, 2HCl White ... Protein synthesis inhibitor. Inhibits translation by ... chains. Induces DNA fragmentation in thymocytes ... Purity: ≥98% by TLC. ...
Mouse monoclonal antibody to PPP2R2C - protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform...
...
Biology Products: