Navigation Links
3D microgels 'on-demand' offer new potential for cell research
Date:2/26/2014

Stars, diamonds, circles.

Rather than your average bowl of Lucky Charms, these are three-dimensional cell cultures generated by an exciting new digital microfluidics platform, the results of which have been published in Nature Communications this week by researchers at the University of Toronto. The tool, which can be used to study cells in cost-efficient, three-dimensional microgels, may hold the key to personalized medicine applications in the future.

"We already know that the microenvironment can greatly influence cell fate," says Irwin A. Eydelnant, recent doctoral graduate from IBBME and first author of the publication. "The important part of this study is that we've developed a tool that will allow us to investigate the sensitivity of cells to their 3D environment."

"Everyone wants to do three-dimensional (3D) cell culture," explains Aaron Wheeler, Professor and Canada Research Chair in Bioanalytical Chemistry at the Institute of Biomaterials & Biomedical Engineering (IBBME), the Department of Chemistry, and the Donnelly Centre for Cellular and Biomolecular Research (DCCBR) at the University of Toronto. "Cells grown in this manner share much more in common with living systems than the standard two-dimensional (2D) cell culture format," says Wheeler, corresponding author of the study.

More naturalistic, 3D cell cultures are a challenge to grow. "The reagents are expensive, the materials are inconvenient for automation, and 3D matrices break down upon repeated handling," explains Wheeler, who was named an Inventor of the Year by the University of Toronto in 2012.

Eydelnant was able to address these difficulties by adapting a digital microfluidics platform first created in the Wheeler lab. Cells, caught up in a hydrogel material, are gently flowed across a small field that, on a screen, looks much like a tiny chessboard. The cells are strategically manipulated by a small electric field across a cutout shape
'/>"/>

Contact: Erin Vollick
comm.ibbme@utoronto.ca
416-946-8019
University of Toronto
Source:Eurekalert

Page: 1 2

Related biology news :

1. Osteoarthritis medicine delivered on-demand
2. Mercy Lab Offers Faster On-demand Diabetes Testing, Cellular Studies
3. New biological scaffold offers promising foundation for engineered tissues
4. Paper offers insights into network that plays crucial role in cell function and disease
5. Genetic function discovered that could offer new avenue to cancer therapies
6. Space flies offer clues about microgravitys impact on astronauts
7. Natural engineering offers solution against future flooding
8. Scripps Florida scientists offer new insight into neuron changes brought about by aging
9. 2014 ASMCUE and ASM General Meeting collaborate to offer the latest in teaching and research
10. Study offers clues to how plants evolved to cope with cold
11. Blind cavefish offer evidence for alternative mechanism of evolutionary change
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... 2014 Research and Markets ( http://www.researchandmarkets.com/research/fx4bg3/the_global ... "The Global Watermarking and Fingerprinting Markets" report ... http://photos.prnewswire.com/prnh/20130307/600769 This insight provides an ... fingerprinting markets. Watermarking aims to control and monitor ...
(Date:12/19/2014)... Dec. 18, 2014 Research and Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ... Monitor: North America Perimeter Security Systems Market" report to ... The North American perimeter security market is estimated to ... Although the U.S. market holds a larger share in this ...
(Date:12/17/2014)... DUBLIN , Dec. 15, 2014 Research and Markets ... of the "Samsung Galaxy S5 - Home Button ... offering. http://photos.prnewswire.com/prnh/20130307/600769 ... the iPhone 5S, Samsung introduces for the first time ...
Breaking Biology News(10 mins):The Global Watermarking and Fingerprinting Markets 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2
... - Researchers are developing new technologies that combine ... and tiny particles such as bacteria, viruses and ... drug manufacturing to food safety. The technologies ... "lab-on-a-chip" applications, or miniature instruments that perform measurements ...
... shown that, from the time that a woman starts trying ... on the time to pregnancy. Professor Roger Hart told ... and Embryology that the negative effect of gum disease on ... effect of obesity. Periodontal (gum) disease is a ...
... to the deserts of East Africa and has unique physical traits ... It has a lack of pain sensation in its skin ... underground with limited oxygen supply. For the first ... understand its longevity and resistance to diseases of ageing. Researchers ...
Cached Biology News:Laser, electric fields combined for new 'lab-on-chip' technologies 2Laser, electric fields combined for new 'lab-on-chip' technologies 3Gum disease can increase the time it takes to become pregnant 2Gum disease can increase the time it takes to become pregnant 3Scientists sequence DNA of cancer-resistant rodent 2
(Date:1/22/2015)... / Rootstown, OH (PRWEB) January 22, 2015 ... platform, announced today that it has received AOAC-PTM Certifications for ... O1O3, O111, O121, and O145; collectively referred to as STEC ... O157, at 1 colony forming unit (cfu) per 325 g ...
(Date:1/22/2015)... DE (PRWEB) January 22, 2015 Controlled ... Pistoia Alliance, which helps companies check the legal requirements ... to expand to China. , As their international ... are globally adopting software solutions built as a result ...
(Date:1/22/2015)... 2015   Cypher Genomics, Inc., the leading ... SQNM ), the leading molecular diagnostics company, ... noninvasive prenatal tests (NIPT). Through this agreement, Sequenom ... to advance analysis of clinically-relevant fetal sub-chromosomal variants ...
(Date:12/25/2014)... report “Service Quality Management and Telco Customer Experience Management ... Advancements, Worldwide Forecasts & Analysis (2014-2019)” defines and segments ... revenues. , Browse 152 market data tables, 19 ... “Service Quality Management (SQM) and Telco Customer Experience Management ...
Breaking Biology Technology:Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2Global Compliance Service for Controlled Substances to Expand to China 2Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4
... Inc.,("Oncolytics") (TSX:ONC, NASDAQ:ONCY) today announced its financial results,and ... 31, 2008., "We are currently enrolling or ... four exploring the use of REOLYSIN(R) as a ... combination with a variety of,chemotherapies, immune modulation and ...
... batch of bluetongue Bovilis BTV8 vaccine released to supply Northern ... ... Animal Health (NYSE: SGP ) released the first batch,of Bovilis ... company, combining after the acquisition in 2007 the,strength of Intervet and ...
... BOSTON, April 30 Today John C. Lechleiter,Ph.D., ... (NYSE: LLY ), provided,insight into the future ... that,key players, significant investments in the sector are ... Conference, a gathering of,policymakers, business leaders and academics, ...
Cached Biology Technology:Oncolytics Biotech Inc. Announces 2008 First Quarter Results 2Oncolytics Biotech Inc. Announces 2008 First Quarter Results 3Oncolytics Biotech Inc. Announces 2008 First Quarter Results 4Oncolytics Biotech Inc. Announces 2008 First Quarter Results 5Oncolytics Biotech Inc. Announces 2008 First Quarter Results 6Oncolytics Biotech Inc. Announces 2008 First Quarter Results 7Oncolytics Biotech Inc. Announces 2008 First Quarter Results 8Oncolytics Biotech Inc. Announces 2008 First Quarter Results 9Oncolytics Biotech Inc. Announces 2008 First Quarter Results 10Oncolytics Biotech Inc. Announces 2008 First Quarter Results 11Oncolytics Biotech Inc. Announces 2008 First Quarter Results 12Oncolytics Biotech Inc. Announces 2008 First Quarter Results 13Oncolytics Biotech Inc. Announces 2008 First Quarter Results 14Oncolytics Biotech Inc. Announces 2008 First Quarter Results 15Oncolytics Biotech Inc. Announces 2008 First Quarter Results 16Oncolytics Biotech Inc. Announces 2008 First Quarter Results 17Oncolytics Biotech Inc. Announces 2008 First Quarter Results 18Oncolytics Biotech Inc. Announces 2008 First Quarter Results 19Oncolytics Biotech Inc. Announces 2008 First Quarter Results 20Oncolytics Biotech Inc. Announces 2008 First Quarter Results 21Oncolytics Biotech Inc. Announces 2008 First Quarter Results 22Oncolytics Biotech Inc. Announces 2008 First Quarter Results 23Oncolytics Biotech Inc. Announces 2008 First Quarter Results 24Oncolytics Biotech Inc. Announces 2008 First Quarter Results 25Oncolytics Biotech Inc. Announces 2008 First Quarter Results 26Oncolytics Biotech Inc. Announces 2008 First Quarter Results 27Oncolytics Biotech Inc. Announces 2008 First Quarter Results 28Oncolytics Biotech Inc. Announces 2008 First Quarter Results 29Oncolytics Biotech Inc. Announces 2008 First Quarter Results 30Oncolytics Biotech Inc. Announces 2008 First Quarter Results 31Oncolytics Biotech Inc. Announces 2008 First Quarter Results 32Oncolytics Biotech Inc. Announces 2008 First Quarter Results 33Intervet/Schering-Plough Animal Health Outlines Strength of the Combination 2Intervet/Schering-Plough Animal Health Outlines Strength of the Combination 3Lilly CEO Urges Policy Prescriptions to Help Ensure Public and Private Biotech Investments Generate Dividends and U.S. Job Growth 2
GM130 Immunogen: Recombinant purified rat GM130 Family / Subclass 1: Signal Transduction Storage: 4 C...
NATIVE RAT OSTEOCALCIN...
... Specifications(L x W x H): 17 ... 5/16"18.7 lbsCapacity: 12 slidesTime: Programmable 0 - ... denaturation and hybridization steps 40 user programmable ... and Fixed temperature) Rapid temperature ramp-up from ...
Defender against cell death 1...
Biology Products: