Navigation Links
3-substituted indolones as novel therapeutic compounds for neurodegenerative conditions
Date:10/28/2008

efficacious than GW5074 and that display no cytotoxicity even when used at high doses. These 3-substituted indolones are thus novel and promising candidate therapeutic agents for pre-clinical testing against human neurodegenerative conditions. According to Dr. D'Mello, "Studies into the mechanisms underlying neuronal apoptosis has identified several molecules that can be targeted in developing drugs to treat neurodegenerative diseases. Some of these have been tested in human clinical studies but have not proven to be effective at reducing neurodegeneration in patients. Our study has identified some 3-substituted indolones that might be suitable for development as therapeutic agents. The structure-activity relationship analysis we have described in our report, although not exhaustive, also provides useful information on which other efficacious 3-substituted indolones can be synthesized and tested in pre-clinical and clinical studies".

Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine, said "The work by D'Mello and colleagues has provided the basis for testing new versions of 3-substituted indolones for efficacy in the treatment of Alzheimer's disease and other neurodegenerative disorders. These drugs provide promising new therapeutic approaches to deal with the underlying cause of these disorders: neuronal cell death."


'/>"/>

Contact: Dr. Santosh R. D'Mello
dmello@utdallas.edu
972-883-2520
Society for Experimental Biology and Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. UT Southwestern researcher awarded Gates Foundation grant for novel vaccine development
2. GEN reports on novel tools for deciphering biological networks
3. Novel publishing approach puts textbook in more hands
4. Cold Spring Harbor Laboratory scientists trace a novel way cells are disrupted in cancer
5. Childrens National researchers develop novel anti-tumor vaccine
6. LIAI launches new division to look at novel approaches to heart disease and inflammation
7. Conaway Lab identifies novel mechanism for regulation of gene expression
8. Scientists identify novel inhibitor of human microRNA
9. Using novel tool, UD researchers dig through cell trash and find treasure
10. Novel anti-cancer mechanism found in long-lived rodents
11. Novel fungus helps beetles to digest hard wood
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... of animals and plants. The central problem in pattern ... a reliable manner to give specific spatial patterns of ... formation is a classic paradigm in developmental biology. Cell ... flag, is caused by a gradient of a signalling ... of the morphogen a "blue", "white" or "red" gene ...
(Date:9/23/2014)... SPRINGS, Florida , September 23, 2014 ... for innovative companies in tech sector position for significant investor ... products & services.  Companies in focus today are: NXT-ID, Inc. ... BABA ), Mobileye N.V. (NYSE: MBLY ... Robotics Ltd. (NASDAQ: RWLK) NXT-ID, Inc. (NASDAQ: ...
(Date:9/22/2014)... GAINESVILLE, Fla. --- Many native species have vanished ... University of Florida scientists have discovered how fossils ... , The key lies in organic materials found ... ancient ecosystems functioned, according to a new study ... the Journal of Herpetology . Pre-human island ...
Breaking Biology News(10 mins):Recreating the stripe patterns found in animals by engineering synthetic gene networks 2Latest Blockbuster IPOs and Up Listings for Global Tech Stocks Attracting Major Attention as Traders Focus on Key Economic Data Due this Week 2Latest Blockbuster IPOs and Up Listings for Global Tech Stocks Attracting Major Attention as Traders Focus on Key Economic Data Due this Week 3Latest Blockbuster IPOs and Up Listings for Global Tech Stocks Attracting Major Attention as Traders Focus on Key Economic Data Due this Week 4Latest Blockbuster IPOs and Up Listings for Global Tech Stocks Attracting Major Attention as Traders Focus on Key Economic Data Due this Week 5Latest Blockbuster IPOs and Up Listings for Global Tech Stocks Attracting Major Attention as Traders Focus on Key Economic Data Due this Week 6Latest Blockbuster IPOs and Up Listings for Global Tech Stocks Attracting Major Attention as Traders Focus on Key Economic Data Due this Week 7Answer to restoring lost island biodiversity found in fossils 2
... GABLES, FL. -- The key to understanding how future hurricanes ... native coastal forests lurks below the surface, according to a ... the familiar mangroves that line the coasts lie hardwood hammocks ... the soils., University of Miami (UM) Ecologist Donald L. DeAngelis, ...
... of Houston (UH) vision scientist has received a $1.85 ... to investigate whether his techniques are more effective than ... could lead to developing a way to earlier diagnose ... assistant professor of vision science and biomedical engineering, uses ...
... warming and instead reduce fossil-fuel use for the sake of ... from the University of Washington and one from the University ... current issue of the journal Nature (Jan. 26) ... trump the environment as a reason to curb the use ...
Cached Biology News:Living on the edge: An innovative model of mangrove-hammock boundaries in Florida 2Sharper imaging in glaucoma focus of $1.85 million NIH grant 2Sharper imaging in glaucoma focus of $1.85 million NIH grant 3Commentary in Nature: Can economy bear what oil prices have in store? 2Commentary in Nature: Can economy bear what oil prices have in store? 3
(Date:9/23/2014)... NY (PRWEB) September 23, 2014 Marktech ... of deep ultra violet emitters in the 280 nm ... standard UV emitters which range from 280nm to 405nm. ... and water sanitation as well as curing. Mark Campito, ... line of special interest to manufacturers is that we ...
(Date:9/23/2014)... New spin-out from Cancer ... Innovation Capital and Johnson & Johnson Development Corporation  ... focused on harnessing the potential of circulating tumour ... treatment, today announced it has raised £4m in ... including Cambridge Innovation Capital and Johnson & Johnson ...
(Date:9/22/2014)... , September 22, 2014 ... announced the addition of the "Global Biotechnology ...      (Logo: http://photos.prnewswire.com/prnh/20130307/600769) Biotechnology ... added to a system to detect and examine ... are generally used in laboratories to prepare, collect, ...
(Date:9/22/2014)... new star-shaped molecule made up of interlocking rings, which is ... , Known as a ,Star of David, molecule, scientists have ... a century and the team,s findings are published in the ... molecular triangles, entwined about each other three times into a ... is 114 atoms in length around the perimeter. The molecular ...
Breaking Biology Technology:Marktech Introduces its New Line of Deep UV Emitters 2Inivata Raises £4m to Realise the Potential of ctDNA Analysis to Improve Cancer Treatment Through Simple Blood Tests 2Inivata Raises £4m to Realise the Potential of ctDNA Analysis to Improve Cancer Treatment Through Simple Blood Tests 3Inivata Raises £4m to Realise the Potential of ctDNA Analysis to Improve Cancer Treatment Through Simple Blood Tests 4Global Biotechnology Reagents Market 2014-2018: Key Vendors are Agilent, BD Biosciences, Bio-Rad, F. Hoffmann-La Roche, Sigma-Aldrich and Thermo Fisher 2Global Biotechnology Reagents Market 2014-2018: Key Vendors are Agilent, BD Biosciences, Bio-Rad, F. Hoffmann-La Roche, Sigma-Aldrich and Thermo Fisher 3
... N.J., June 27 Wyeth (NYSE: WYE ) ... Executive,Officer, has assumed the additional position of Chairman of ... a previously announced election by the,Company,s Board of Directors, ... in April 2006 when Mr. Poussot was promoted to ...
... and Received over $235 Million, SOUTH SAN FRANCISCO, ... announced today that the company and,GlaxoSmithKline, Inc. (NYSE: ... conclusion on October 27, 2008, as scheduled. Under the,terms ... up to two of the,compounds in the collaboration for ...
... between 30 and 50 million people. In the infected ... distress syndrome (ARDS). This fatal condition is a massive ... severely damaged. ARDS can be induced by various bacterial ... could be toxic gases that are inhaled or gastric ...
Cached Biology Technology:Exelixis and GlaxoSmithKline Agree to Successfully Conclude Six-Year Discovery and Development Collaboration 2Exelixis and GlaxoSmithKline Agree to Successfully Conclude Six-Year Discovery and Development Collaboration 3Exelixis and GlaxoSmithKline Agree to Successfully Conclude Six-Year Discovery and Development Collaboration 4Exelixis and GlaxoSmithKline Agree to Successfully Conclude Six-Year Discovery and Development Collaboration 5New strategies against bird flu 2