Navigation Links
3-substituted indolones as novel therapeutic compounds for neurodegenerative conditions
Date:10/28/2008

Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS), disrupt the quality of life for patients, put a tremendous burden on family caregivers, and cost society billions of dollars annually. The most consistent risk factor for developing neurodegenerative disease is aging. Because of the dramatic increase in life expectancy, the incidence of individuals afflicted with the aging-associated disorders is on the rise representing a major health problem. A commonality shared among this diverse set of disorders is the progressive and relentless loss of certain populations of neurons. Current medications for neurodegenerative diseases alleviate only the symptoms associated with these diseases but do not affect the underlying cause degeneration of neurons. Because neuronal loss continues unabated, such palliative treatments have no effect on disease progression. The identification of small-molecule inhibitors of neuronal death is thus of urgent and critical importance.

In the November issue of EBM, researchers at the University of Texas at Dallas and Southern Methodist University have identified a class of compounds, 3-substituted indolones, that can protect neurons from degeneration. Furthermore, the group has conducted a structure-activity relationship study to identify substituent groups that are important for neuroprotective efficacy. A previous study by the same group demonstrated that one of these 3-substituted indolones, called GW5074, prevents neurodegeneration and improves behavioral outcome in a mouse model of neurodegeneration. The senior author, Dr. Santosh D'Mello said "More recent but unpublished work by our group and Doris Kretzschmar, a collaborator at the Oregon Health and Science University, found that GW5074 and other related 3-substituted indolones are also protective in a fly model of Alzheimer's disease. " The current study identifies several compounds that are more
'/>"/>

Contact: Dr. Santosh R. D'Mello
dmello@utdallas.edu
972-883-2520
Society for Experimental Biology and Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. UT Southwestern researcher awarded Gates Foundation grant for novel vaccine development
2. GEN reports on novel tools for deciphering biological networks
3. Novel publishing approach puts textbook in more hands
4. Cold Spring Harbor Laboratory scientists trace a novel way cells are disrupted in cancer
5. Childrens National researchers develop novel anti-tumor vaccine
6. LIAI launches new division to look at novel approaches to heart disease and inflammation
7. Conaway Lab identifies novel mechanism for regulation of gene expression
8. Scientists identify novel inhibitor of human microRNA
9. Using novel tool, UD researchers dig through cell trash and find treasure
10. Novel anti-cancer mechanism found in long-lived rodents
11. Novel fungus helps beetles to digest hard wood
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/18/2014)... , August 19, 2014 ... biometric authentication in smart devices  Trustonic, ... for smart devices, and Fingerprint Cards AB (FPC) ... of FIDO Ready™ secure biometric authentication on connected ... touch fingerprint sensors (FPC1020, FPC1021 and FPC1150) and ...
(Date:8/18/2014)... Ohio Fish species native to a major Arizona ... habitat by 2050 as surface water flow is reduced ... , Most of these fish species, found in the ... survival relies on easy access to various resources throughout ... the speckled dace (Rhinichthys osculus), roundtail chub (Gila robusta) ...
(Date:8/18/2014)... Researchers from Aarhus University, Denmark, and the University of Wisconsin-Madison, ... exposure of species to both climate and land use change. ... species in the face of combined rates of climate and ... , Their results, which have just been published in ... vulnerable to losses in biodiversity and ecosystem function due to ...
Breaking Biology News(10 mins):Trustonic and Fingerprint Cards Collaborate to Bring Secure Biometrics to Connected Devices 2Trustonic and Fingerprint Cards Collaborate to Bring Secure Biometrics to Connected Devices 3Trustonic and Fingerprint Cards Collaborate to Bring Secure Biometrics to Connected Devices 4Climate change will threaten fish by drying out Southwest US streams, study predicts 2Climate change will threaten fish by drying out Southwest US streams, study predicts 3The double threat of climate and land use change enhances risks to biodiversity 2
... funded by the National Institute of Allergy and Infectious ... (NIH), have engineered a powerful inhibitor of anthrax toxin ... "This novel approach to the design of anthrax antitoxin ... it may have in anthrax treatment, but also because ...
... have discovered the gene responsible for a type of ... coordination. , This is the first neurodegenerative disease shown ... spectrin which plays an important role in the maintaining ... historical implications as well--the gene was identified in an ...
... study of the travels of the malaria parasite Plasmodium ... Paris found the parasites developing in an unexpected place: ... lymph nodes almost certainly has implications for the mammalian ... Institute (HHMI) international research scholar who led the study. ...
Cached Biology News:Scientists design potent anthrax toxin inhibitor 2Scientists design potent anthrax toxin inhibitor 3U of MN researchers identify ataxia gene 2Malaria parasites develop in lymph nodes 2Malaria parasites develop in lymph nodes 3
(Date:8/18/2014)... ORLANDO, Fla. , Aug. 18, 2014 ... a biotechnology company pioneering the manufacturing and marketing of ... today that the Company is providing a second notice ... In making the announcement, Noreen Griffin ... "Thank you in advance for your participation in the ...
(Date:8/18/2014)... Vier führende deutsche Augenzentren nehmen ... auf, in der eine Intraokularlinse (IOL) geprüft ... bei allen Entfernungen verbessern, so dass die ... oder Gleitsichtbrille mehr benötigen. Die neue Linse, ... Intraocular Lens (FluidVision akkomodative Intraokularlinse) vertrieben ...
(Date:8/16/2014)... have found a way to make atomic-force microscope probes ... as small as the weight of an individual virus. ... National University (ANU), hinges on using laser beams to ... , "The level of sensitivity achieved after cooling is ... a large virus that is 100 billion times lighter ...
(Date:8/15/2014)... Actor Robin Williams’ suicide has prompted a ... Show reports, someone commits suicide every 13 minutes. ... from the outside in, I contend that it is ... from the inside out,” says neuroscientist Cynde Margritz of ... of the accounts of Williams’ suicide have defined depression ...
Breaking Biology Technology:TNI BioTech Inc., provides 2nd Notice of Annual Meeting September 4, 2014 2TNI BioTech Inc., provides 2nd Notice of Annual Meeting September 4, 2014 3TNI BioTech Inc., provides 2nd Notice of Annual Meeting September 4, 2014 4Implantation einer revolutionären akkommodativen Linse bei Katarakt-Patienten in deutschen Augenzentren im Rahmen einer internationalen klinischen Studie 2Implantation einer revolutionären akkommodativen Linse bei Katarakt-Patienten in deutschen Augenzentren im Rahmen einer internationalen klinischen Studie 3Implantation einer revolutionären akkommodativen Linse bei Katarakt-Patienten in deutschen Augenzentren im Rahmen einer internationalen klinischen Studie 4Laser makes microscopes way cooler 2Neurofeedback Helps Alleviate the Underlying Causes of Depression 2Neurofeedback Helps Alleviate the Underlying Causes of Depression 3
... researchers in cardiovascular medicine will present their most-recent findings ... Scientific Sessions, June 11-14, 2011 in Montreal, Quebec, Canada. ... diagnosis and treatment of heart disease and the utilization ... text of the press releases, please visit the "ASE ...
... 10, 2011 Newswise -- Osteoarthritis (OA) is one ... time, affecting 27 million Americans. In an effort to ... prevention, Hospital for Special Surgery (HSS) will host an ... The Hospital, internationally recognized for its leadership ...
... WORCESTER, Mass. and TORONTO, June 10, 2011 Generex ... the results of the Company,s annual meeting of stockholders ... http://photos.prnewswire.com/prnh/20110106/NY25057LOGO-b ) At the annual meeting of ... the Board of Directors until the next annual meeting ...
Cached Biology Technology:Researchers From More Than 30 Countries Share Findings About the Use of Ultrasound in the Prevention, Diagnosis and Treatment of Heart Disease 2Hospital for Special Surgery to Host International Arthritis Summit: Frontiers in Osteoarthritis Research, Prevention and Care 2Hospital for Special Surgery to Host International Arthritis Summit: Frontiers in Osteoarthritis Research, Prevention and Care 3Generex Announces Results of Annual Stockholders' Meeting 2Generex Announces Results of Annual Stockholders' Meeting 3Generex Announces Results of Annual Stockholders' Meeting 4
Immunogen: Recombinant full length protein, corresponding to amino acids 1-435 of Human AP2M1. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Anti-Dynamin Monoclonal Antibody Description: 100 g Research Focus: neuroscience Storage: -20C Shipping Temperature: 4C...
cysteine and glycine-rich protein 2,...
BKBeta2 potassium channel Antigen: Fusion protein amino acids 1-41 (N-terminus) and 218-235 (C-terminus) of mouse BKBeta2 Accession Number: Q9CZM9...
Biology Products: