Navigation Links
3-substituted indolones as novel therapeutic compounds for neurodegenerative conditions
Date:10/28/2008

Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS), disrupt the quality of life for patients, put a tremendous burden on family caregivers, and cost society billions of dollars annually. The most consistent risk factor for developing neurodegenerative disease is aging. Because of the dramatic increase in life expectancy, the incidence of individuals afflicted with the aging-associated disorders is on the rise representing a major health problem. A commonality shared among this diverse set of disorders is the progressive and relentless loss of certain populations of neurons. Current medications for neurodegenerative diseases alleviate only the symptoms associated with these diseases but do not affect the underlying cause degeneration of neurons. Because neuronal loss continues unabated, such palliative treatments have no effect on disease progression. The identification of small-molecule inhibitors of neuronal death is thus of urgent and critical importance.

In the November issue of EBM, researchers at the University of Texas at Dallas and Southern Methodist University have identified a class of compounds, 3-substituted indolones, that can protect neurons from degeneration. Furthermore, the group has conducted a structure-activity relationship study to identify substituent groups that are important for neuroprotective efficacy. A previous study by the same group demonstrated that one of these 3-substituted indolones, called GW5074, prevents neurodegeneration and improves behavioral outcome in a mouse model of neurodegeneration. The senior author, Dr. Santosh D'Mello said "More recent but unpublished work by our group and Doris Kretzschmar, a collaborator at the Oregon Health and Science University, found that GW5074 and other related 3-substituted indolones are also protective in a fly model of Alzheimer's disease. " The current study identifies several compounds that are more
'/>"/>

Contact: Dr. Santosh R. D'Mello
dmello@utdallas.edu
972-883-2520
Society for Experimental Biology and Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. UT Southwestern researcher awarded Gates Foundation grant for novel vaccine development
2. GEN reports on novel tools for deciphering biological networks
3. Novel publishing approach puts textbook in more hands
4. Cold Spring Harbor Laboratory scientists trace a novel way cells are disrupted in cancer
5. Childrens National researchers develop novel anti-tumor vaccine
6. LIAI launches new division to look at novel approaches to heart disease and inflammation
7. Conaway Lab identifies novel mechanism for regulation of gene expression
8. Scientists identify novel inhibitor of human microRNA
9. Using novel tool, UD researchers dig through cell trash and find treasure
10. Novel anti-cancer mechanism found in long-lived rodents
11. Novel fungus helps beetles to digest hard wood
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... TX (4/23/14) -- Researchers have found evidence of ... factors that increase aggressive behavior in children, especially ... not all children exposed to prenatal smoking will ... will not," said Brian Boutwell, Assistant Professor at ... and senior author on the study. "One ...
(Date:4/23/2014)... manufacturers are turning away from using triclosan as an ... health concerns. And now scientists are reporting new evidence ... in the ACS journal Chemical Research in Toxicology ... substance called octylphenol, promoted the growth of human breast ... in mice. , Kyung-Chul Choi and colleagues note that ...
(Date:4/23/2014)... to date of the family of bacteria that ... strategies and reveals surprising findings about the bacteria,s ... public health strategies to control this respiratory disease, ... Genomic analysis of 343 strains of the ... collected over the last 100 years illustrates how ...
Breaking Biology News(10 mins):Genetics risk, prenatal smoking may predict behavioral problems 2In lab tests, the antimicrobial ingredient triclosan spurs growth of breast cancer cells 2Impact of whooping cough vaccination revealed 2
... researcher, please contact the Communications and External Relations staff member ... on ORNL and its research and development activities, please refer ... general media-related question or comment, you can send it to ... fuel pellets . . . Oak Ridge ...
... Spain: The numbers of cycles of preimplantation genetic diagnosis ... 2,700 reported in 2004 (the most recent year for ... screen for a growing number of genetically related conditions, ... the targeted condition are available for transfer and the ...
... that gladdens a mother,s heart also lights up the reward ... in a report that appears in the journal Pediatrics ... out the special mother-infant bond and how it sometimes go ... BCM and Texas Children,s Hospital and a research associate in ...
Cached Biology News:Story tips from the Department of Energy's Oak Ridge National Laboratory, July 2008 2Story tips from the Department of Energy's Oak Ridge National Laboratory, July 2008 3Should embryos with a hereditary disorder be transferred if no unaffected embryos are available? 2Should embryos with a hereditary disorder be transferred if no unaffected embryos are available? 3A baby's smile is a natural high 2
(Date:1/15/2014)... SAN JOSE, California , January 15, 2014 ... antibody-drug conjugates for cancer, today announced the appointment of Thomas ... Reynolds has over 20 years, development experience gained in the ... Genetics. "I am delighted to welcome Tom at ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 Two champions ... continued their sponsorship of an annual competition for middle ... and access to, innovative STEM study. The competition presents ... TEAMS: Tests of Engineering Aptitude, Mathematics, and Sciences ...
(Date:1/15/2014)... 15, 2014 AudioNotch is the internet's ... for the treatment of tinnitus. Patients listen to sound ... over a period of weeks to months, their tinnitus volume ... two forms: Notched Music and Notched White Noise. Now, AudioNotch ...
(Date:1/14/2014)... , Jan. 14, 2014  3D Communications, a leading provider of ... regulatory, business, and media events in the United States ... former associate Virginia Cox , JD, is returning to the ... Virginia Cox re-joins 3D after more than two years of ...
Breaking Biology Technology:Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5Former FDA Associate Commissioner Returns To 3D Communications 2
... On Thursday, December 9th, Mediaplanet published ... spearheading an industry-wide call to action advocating consumer ... us confront society,s most pressing challenges. By teaming ... Mediaplanet ,s ,Biotechnology, encourages appropriate policy action and ...
... China-Biotics, Inc. ("China-Biotics" or "the Company"), (Nasdaq: ... probiotics products in China, today announced that it has ... promissory notes for cash two days before the December ... notes were originally issued on December 11, 2007. The ...
... 8, 2010 Martek Biosciences Corporation (Nasdaq: MATK ... and fiscal year ended October 31, 2010. Total revenues for ... fourth quarter of fiscal 2009. Fourth quarter non-GAAP earnings per ... diluted share in last year,s fourth quarter.  For the full ...
Cached Biology Technology:The Biotechnology Industry Organization and Critical Path Institute Partner With Mediaplanet, Biocom, and the University of California Office to Spotlight the Science That Is Healing, Fueling and Feeding Our Global Population 2China-Biotics Announces Redemption of $25 million in Senior Convertible Notes 2China-Biotics Announces Redemption of $25 million in Senior Convertible Notes 3Martek Announces Fourth Quarter and FY 2010 Financial Results 2Martek Announces Fourth Quarter and FY 2010 Financial Results 3Martek Announces Fourth Quarter and FY 2010 Financial Results 4Martek Announces Fourth Quarter and FY 2010 Financial Results 5Martek Announces Fourth Quarter and FY 2010 Financial Results 6Martek Announces Fourth Quarter and FY 2010 Financial Results 7Martek Announces Fourth Quarter and FY 2010 Financial Results 8Martek Announces Fourth Quarter and FY 2010 Financial Results 9Martek Announces Fourth Quarter and FY 2010 Financial Results 10Martek Announces Fourth Quarter and FY 2010 Financial Results 11Martek Announces Fourth Quarter and FY 2010 Financial Results 12
...
... Gel loading buffer is especially formulated for ... nucleic acids. The gel loading solution contains ... to add density and facilitate sample loading. ... that require divalent cations and SDS has ...
... HPLC systems. , Integrated Instrument Control , ... EZChrom Elite can be configured with ... This provides a completely integrated system to control instrument's operation, collect ... ...
Rabbit anti Xanthine Oxidase Xanthine Oxidase, Bovine Buttermilk...
Biology Products: