C. neoformans causes serious infections in people with weakened immune systems, leading to more than half a million deaths per year worldwide. Doering's lab is investigating unique aspects of cryptococcal biology with the goals of understanding basic processes and finding targets for drugs to fight C. neoformans infection.
Doering is especially interested in C. neoformans' protective capsule, its dominant virulence factor, which is critical for the pathogen to survive in the host and cause disease. She is examining how the polysaccharidecapsule is made and regulated and how it interacts with host cells, using approaches ranging from biochemistry and cell biology to molecular biology and genome analysis.
Doering has recently begun applying high-throughput screening to these questions, which has opened new areas of research.
Fiona B. Marshall, PhD, professor of anthropology and of African & African-American Studies, both in Arts & Sciences, was elected to the Section on Anthropology. She is one of the world's pre-eminent scholars on the origins of agriculture in Africa and on donkey domestication.
Marshall is an African archaeologist whose research incorporates zooarchaeological and ethnoarchaeogical approaches to the beginnings of food production and the development of pastoralism tending of large herds of animals in northeast Africa.
She has focused on selection in African pastoral contexts and microevolutionary approaches to domestication of large mammals, African cattle and donkeys.
In collaboration with the Saint Louis Zoo, she is currently studying behavior of the African wild ass and the relationship of sociality to domestication processes.
The research of Marshall and her students also examines variation in social organization and subsistence strategies among Holocene African hunter-gatherers and early pastoralists
|Contact: Beth Miller|
Washington University School of Medicine