Navigation Links
3-D tumor models improve drug discovery success rate
Date:7/20/2012

otic core more faithfully mimicking the microenvironments of human tumors. Additionally, spheroids can be grown in the presence of compounds that mimic extra cellular matrix the environment that surrounds and very much affects the growth and behaviors of human tumors.

Instead of indiscriminately killing cells, modern cancer drugs tend to target cells with very specific genetic mutations that turn on and off very specific growth and survival mechanisms that in turn very frequently depend on everything else going on in and around the cells. Using MCTS models, researchers can ask questions about how a drug will penetrate a tumor's heterogeneous 3D structure and how a drug will interact with the environment surrounding these tiny tumors.

"Though these MCTS models have been around since the 1970s, only recently has technology made it possible to use them in place of 2D models for the high-throughput screening used in drug discovery," LaBarbera says.

Remember those millions of cancer cells organized in independent divots that researchers hit with drugs? We're fairly tied to the technology that reads the results of these divots. But micro-technologies now allow multicellular tumor spheroids to be cultured in place of 2D cell cultures using high-throughput micro-well plates we can use the same drug testing machinery on these new models. Likewise, materials science technology now exists to grow cells within semipermeable membranes, helping researchers define the shape of the eventual spheres. And as futuristic as it undoubtedly sounds, magnetic cell levitation can help alleviate the problem of cells sticking to the plastic well surface, which limits spheroid growth.

The recent practicality of high-throughput MCTS screening leads LaBarbera to call today a "renaissance" for the technique.

Of course, this 3D testing is initially more expensive and more challenging. "A lot of researchers try to get cost down to pennies per well
'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. The loss of a protein makes jump the tumor to the lymph node
2. Nanotherapy: Treating deadly brain tumors by delivering big radiation with tiny tools
3. Dental X-rays linked to common brain tumor
4. TGen leads new National Institutes of Health study of brain tumors
5. Immune-response genes affecting breast tumor eradication
6. A single stem cell mutation triggers fibroid tumors
7. Clusters of cooperating tumor-suppressor genes are found in large regions deleted in common cancers
8. Cancerous tumors deliver pro-metastatic information in secreted vesicles
9. Researchers identify need to sample multiple tumor zones in breast cancer
10. Tumor microenvironment helps skin cancer cells resist drug treatment
11. BGI debuts new tool PDXomics for tumor xenograft research and applications
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... Dec. 15, 2014 The Defense Logistics Agency is ... and prevent counterfeit microcircuits from entering into its supply ... in-house microcircuit anti-counterfeit initiative dubbed DNA marking. The capability ... their reliability throughout the supply chain. The new quality ...
(Date:12/17/2014)... RALEIGH, N.C. , Dec. 16, 2014 Valencell, ... licensed its PerformTek biometric technology to industry leaders such ... highly accurate, clinically validated, biometric wearable products. These products ... 6-9 in Las Vegas . ...
(Date:12/17/2014)... is fundamentally transforming the travel experience and nowhere is ... past decade, ePassports, biometric readers, and secure document scanners ... control via eGates and Automated Passport Control (APC) Kiosks ... borders across the globe. According to ...
Breaking Biology News(10 mins):Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2
... Sleeping Beauty,s kingdom was overgrown by vines when she fell ... and the University of Wisconsin at Milwaukee received more than ... discover why real vines are overtaking the American tropics. Data ... all cases., "We are witnessing a fundamental structural change in ...
... Athens, Ga. A new University of Georgia ... magnitude of hydrocarbon gases released during the Deepwater Horizon ... to 500,000 tons of gaseous hydrocarbons were emitted into ... large gas dischargewhich generated concentrations 75,000 times the normcould ...
... their latest fossil discovery from the field to the ... on a laptop. But sharing that data as a ... currently lacking, say paleontologists at Southern Methodist University in ... technology to capture field data of a huge 110 ...
Cached Biology News:Why are vines overtaking the American tropics? 2Study finds massive flux of gas, in addition to liquid oil, at BP well blowout in Gulf 2Study finds massive flux of gas, in addition to liquid oil, at BP well blowout in Gulf 33-D digital dinosaur track download: A roadmap for saving at-risk natural history resources 23-D digital dinosaur track download: A roadmap for saving at-risk natural history resources 33-D digital dinosaur track download: A roadmap for saving at-risk natural history resources 4
(Date:1/22/2015)... , Jan. 22, 2015   Cypher Genomics, Inc., ... Inc. (NASDAQ: SQNM ), the leading ... for next generation noninvasive prenatal tests (NIPT). Through ... technology, called Mantis™, to advance analysis of clinically-relevant ...
(Date:12/24/2014)... , Dec. 24, 2014  United Therapeutics Corporation (NASDAQ: ... MDT ) has submitted a pre-market approval ... for the use of Medtronic,s SynchroMed ® II ... for use with United Therapeutics, Remodulin ® (treprostinil) ...
(Date:12/24/2014)... December 23, 2014 GMO corn cases filed ... are in the process of being consolidated in a Kansas ... Re: Syngenta AG MIR 162 Corn Litigation, MDL No. 2591 ... , Management of the Syngenta GMO corn multidistrict litigation (MDL) ...
(Date:12/24/2014)... 2014 The report provides basic ... classification, application and industry overview. This report also ... structure. Production is separated by regions, technology and ... equipment, downstream client survey, marketing channels, industry development ...
Breaking Biology Technology:Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2Worldwide Methyl Mercaptan Market 2015-2020 Forecasts on Development & Trends Now Available at ReportsnReports.com 2
... , , , , For purification of endotoxin-free ultrapure , ... Features and benefits , , Less ... DNA , Greater than 90% recovery of plasmid DNA , ... , , , ...
... , , , A crucial step ... To improve the critical steps in the target-labeling process, , ... for use with Affymetrix GeneChip expression arrays. The GeneChip ... of an ongoing collaboration between , QIAGEN and ...
... , , , , , , ... specific and sensitive multiplex PCR without the need for time-consuming , optimization ... , , ... ready-to-use master mix , High specificity ...
Cached Biology Technology:EndoFree Plasmid Kits 2EndoFree Plasmid Kits 3EndoFree Plasmid Kits 4GeneChip Sample Cleanup Module for cleanup of cDNA and in vitro , transcribed cRNA 2QIAGEN Multiplex PCR Kit 2QIAGEN Multiplex PCR Kit 3
Rabbit polyclonal to L Kynurenine ( Abpromise for all tested applications). Antigen: Synthetic peptide L Kynurenine conjugated to a protein carrier. Entrez Gene ID: 8942 Swiss Protein ID...
Sheep polyclonal to Salmonella Thomasville ( Abpromise for all tested applications). Antigen: Native Salmonella thomasville...
... polyclonal to Oct6 ( Abpromise for all ... peptide conjugated to KLH derived from within residues ... the amino acid sequence is proprietary) ... Entrez Gene ID: 5453 ...
Mouse monoclonal [X223] to Lamin B1 + B2 - Nuclear Envelope Marker ( Abpromise for all tested applications). entrezGeneID: 4001 SwissProtID: P20700...
Biology Products: