Navigation Links
3-D motion of cold virus offers hope for improved drugs using Australia's fastest supercomputer
Date:7/17/2012

Melbourne researchers are now simulating in 3D, the motion of the complete human rhinovirus, the most frequent cause of the common cold, on Australia's fastest supercomputer, paving the way for new drug development.

Rhinovirus infection is linked to about 70 per cent of all asthma exacerbations with more than 50 per cent of these patients requiring hospitalisation. Furthermore, over 35 per cent of patients with acute chronic obstructive pulmonary disease (COPD) are hospitalised each year due to respiratory viruses including rhinovirus.

A new antiviral drug to treat rhinovirus infections is being developed by Melbourne company Biota Holdings Ltd, targeted for those with these existing conditions where the common cold is a serious threat to their health and could prove fatal.

A team of researchers led by Professor Michael Parker from St Vincent's Institute of Medical Research (SVI) and the University of Melbourne is now using information on how the new drug works to create a 3D simulation of the complete rhinovirus using Australia's fastest supercomputer.

"Our recently published work with Biota shows that the drug binds to the shell that surrounds the virus, called the capsid. But that work doesn't explain in precise detail how the drug and other similar acting compounds work," Professor Parker said.

Professor Parker and his team are working on the newly installed IBM Blue Gene/Q at the University of Melbourne with computational biologists from IBM and the Victorian Life Sciences Computation Initiative (VLSCI).

In production from 1 July 2012, the IBM Blue Gene/Q is the most powerful supercomputer dedicated to life sciences research in the Southern Hemisphere and currently ranked the fastest in Australia.

"The IBM Blue Gene/Q will provide us with extraordinary 3D computer simulations of the whole virus in a time frame not even dreamt of before," Professor Parker said.

"Supercomputer technology
'/>"/>

Contact: Rebecca Scott
rebeccas@unimelb.edu.au
61-383-440-181
University of Melbourne
Source:Eurekalert

Page: 1 2

Related biology news :

1. Motion sensors detect horse lameness earlier than veterinarians, MU study finds
2. Lets get moving: Unraveling how locomotion starts
3. Knee injuries in women linked to motion, nervous system differences
4. A study confirms that long commercials evoke stronger emotions
5. Viruses linked to algae that control coral health
6. Levels of hepatitis C virus higher among African-Americans and males
7. Researchers moving towards ending threat of West Nile virus
8. Flu immunity is affected by how many viruses actually cause the infection
9. Gut microbes battle a common set of viruses shared by global populations
10. Brothers in arms: Commensal bacteria help fight viruses
11. Childhood virus infection linked to prolonged seizures with fever
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... 2014   Atmel® Corporation (NASDAQ: ... touch technology solutions, today launched the industry,s first family ... widest V cc range from 1.7V to 5.5V. ... I 2 C bus communication speeds, and are available ... them ideal for consumer, industrial, computer, and medical applications. ...
(Date:11/18/2014)... --  News Highlights: , ... Partners Data Lake, an agile data and analytics ... allow researcher and clinicians to explore and develop ... of patients , The Partners Data Lake ... Partners system, breaking down physical barriers for collaboration ...
(Date:11/18/2014)... NEW YORK , Nov. 18, 2014 /PRNewswire/ ... iris-based identity authentication solutions, and MorphoTrust USA ... solutions and services, today announced a strategic partnership ... across enterprise, motor vehicle administration (MVA), airport screening ... leader in identity-related solutions, MorphoTrust serves consumers through ...
Breaking Biology News(10 mins):Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 2EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 3
... the world are building an extensive repository of genetically ... function of the approximately 57,000 genes that make up ... Genomics Consortium recently announced the public availability of more ... about half of the known functional genes mapped for ...
... any parent knows, children love sweet-tasting foods. Now, ... Monell Center indicates that this heightened liking for sweetness ... high growth rate. "The relationship between sweet preference ... rapid, caloric demands increase. Children are programmed to ...
... engineers have invented a method that could be used ... from neighboring tissue, an "escape" that can spread the ... lab-on-a-chip, described in the March issue of the journal ... therapies. "Studying cell detachment at the subcellular level ...
Cached Biology News:200,000 rice mutants available worldwide for scientific investigation 2Liking sweets makes sense for kids 2Lab-on-a-chip homes in on how cancer cells break free 2Lab-on-a-chip homes in on how cancer cells break free 3
(Date:12/24/2014)... , Dec. 23, 2014 China ... the "Company"), a leading fully integrated plasma-based biopharmaceutical ... announced that its majority-owned subsidiary, Shandong Taibang Biological ... ("GMP") certification from the China Food and Drug ... production facility. As previously disclosed in the Company,s ...
(Date:12/24/2014)... , Dec. 23, 2014  Rock Creek Pharmaceuticals, ... it has filed a Clinical Trial Application (CTA) with ... products Regulatory Agency (MHRA) seeking regulatory approval to initiate ... molecule, Anatabine Citrate. Contingent on the Company ... a Phase I trial to assess the safety, tolerability ...
(Date:12/22/2014)... /PRNewswire/ - RepliCel Life Sciences Inc. (OTCQB: REPCF) (TSX.V: ... the development of autologous cell therapies, announced today the ... Calgary in conjunction with co-authors from Kyoto University and ... company,s ongoing clinical research using dermal sheath cup (DSC) ... The paper entitled " Hair Follicle Dermal Stem ...
(Date:12/22/2014)... The American Journal of Hematology/Oncology, ... reviews and editorials addressing developments and pathways related ... a provocative article exploring the role of follicle-stimulating ... treatment of prostate cancer. , The article ... possibility that there could be a connection to ...
Breaking Biology Technology:China Biologic Receives GMP Certification for New Coagulation Factor Facility 2China Biologic Receives GMP Certification for New Coagulation Factor Facility 3Rock Creek Pharmaceuticals Files Clinical Trial Application in the UK for Clinical Trials of Anatabine Citrate Formulations 2Rock Creek Pharmaceuticals Files Clinical Trial Application in the UK for Clinical Trials of Anatabine Citrate Formulations 3Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 2Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 3Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 4Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 5Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 2Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 3Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 4
... is showing increasing demand for technical employees, according to ... firm Adecco . , ,In Adecco's "Where the ... state unemployment reports, the company states that the Milwaukee ... positions in the manufacturing, financial, bioscience and banking industries. ...
... fuel technology was developed at the USDA Forest Products ... been acquired by Xethanol Corp. of New ... a wholly owned subsidiary of UTEK Corp., ... Corp. is a biotechnology-driven ethanol production company. , ,The ...
... device industry is becoming more and more intriguing to me. ... some of these key markets and the leading players (particularly ... was the diagnostics market, I decided to dedicate a follow-up ... perspective, Steve Burrill, the premiere cheerleader and prognosticator of biotech ...
Cached Biology Technology:Wisconsin's tech employment shows increase, HR firm reports 2Midwest holds strong position in worldwide diagnostics business 2Midwest holds strong position in worldwide diagnostics business 3
... Ether 30% concentration in ... Surfactant. Clear Solution. Recommended ... 1 mL of 30% ... to 400 mL of ...
... between P-selectin and P-selectin glycoprotein ligand-1 (PSGL-1) ... the lumenal surface of endothelial cells at ... primary role of PSGL-1 in mediating the ... well documented.MAB4092 completely blocks recognition of PSGL-1 ...
Mitotic Kinesin-Like Protein 1 (MKLP-1, KNSL5)...
MMP-1/8 (H-300)...
Biology Products: