Navigation Links
3-D RNA modeling opens scientific doors
Date:4/15/2012

Chapel Hill, NC In a paper published today in the journal Nature Methods, a team from the University of North Carolina at Chapel Hill demonstrates a simple, cost-effective technique for three-dimensional RNA structure prediction that will help scientists understand the structures, and ultimately the functions, of the RNA molecules that dictate almost every aspect of human cell behavior. When cell behavior goes wrong, diseases including cancer and metabolic disorders can be the result.

Over the past five decades, scientists have described more than 80,000 protein structures, most of which are now publicly available and provide important information to medical researchers searching for targets for drug therapy. However, a similar effort to catalogue RNA structures has mapped only a few hundred RNA molecules. As a result, the potential of RNA molecules has just barely been developed as targets for new therapeutics.

"To effectively target these molecules, researchers often need a three-dimensional picture of what they look like," says Nikolay Dokholyan, PhD, professor in the department of biochemistry and biophysics, and the project's co-leader.

"With Dr. Kevin Weeks' lab, we have developed a way to create a three-dimensional map of complex RNAs that are not amenable to study through other methods. It builds on information from a routine laboratory experiment, used in the past to evaluate RNA models from a qualitative standpoint. Our team has created a sophisticated quantitative model that uses this simple information to predict structures for large, complex RNA molecules, which have previously been beyond the reach of modeling techniques," he adds.

Dokholyan, who is a member of UNC Lineberger Comprehensive Cancer Center and director of the UNC Center for Computational and Systems Biology, hopes that the method will help researchers who are trying to target RNAs molecules to change cellular metabolism in a way that ultimately reduces the effects of cellular diseases like cancer. He notes, "Rational, cost-effective screening for small molecules requires a good understanding of the targeted structure. We hope that this method will open doors to new findings applicable to a wide range of human diseases."


'/>"/>

Contact: Ellen de Graffenreid
edegraff@med.unc.edu
919-962-3405
University of North Carolina School of Medicine
Source:Eurekalert

Related biology news :

1. Free AAPS Webinar to explore use of PKPD modeling
2. Modeling Toxoplasma focus of workshop
3. Modeling reef ecosystems focus of workshop
4. Colorado State University scientist simplifies aerosols for modeling
5. Modeling study identifies characteristics of high elk-use areas in western Oregon, Washington
6. Tutorial addresses stochastic modeling in biological process
7. OSU, Oxford, others launch citizen scientist climate modeling initiative
8. Consortium studying mathematical modeling of influenza infection
9. Malaria modeling and control focus of workshop
10. DOE grant joins climate modeling with local, regional empirical data
11. Modeling plant metabolism to optimize oil production
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... BANGALORE, India , April 28, 2016 ... subsidiary of Infosys (NYSE: INFY ), and Samsung ... global partnership that will provide end customers with a ... and payment services.      (Logo: http://photos.prnewswire.com/prnh/20130122/589162 ... for financial services, but it also plays a fundamental part ...
(Date:4/26/2016)... , April 27, 2016 ... "Global Multi-modal Biometrics Market 2016-2020"  report to their ... , The analysts forecast the global ... of 15.49% during the period 2016-2020.  ... of sectors such as the healthcare, BFSI, transportation, ...
(Date:4/15/2016)... , April 15, 2016 ... "Global Gait Biometrics Market 2016-2020,"  report to their ... ) , ,The global gait biometrics market ... 13.98% during the period 2016-2020. Gait ... which can be used to compute factors that ...
Breaking Biology News(10 mins):
(Date:5/23/2016)... BOSTON and LONDON , May 23, ... 10 Could See Frontage Boost Efficiency by 40% - ... - Frontage Enforce Quality, Compliance and Traceability Within the ... (CRO) with labs in the United States ... 10 to be deployed across its laboratory facilities. In addition ...
(Date:5/23/2016)... Palo Alto, CA (PRWEB) , ... May 23, ... ... tank and public interest organization focused on molecular nanotechnology, announced the winners for ... honor of pioneer physicist Richard Feynman, are given in two categories, one for ...
(Date:5/20/2016)... , ... May 20, 2016 , ... The leading Regenerative ... its most experienced veterinary clients have treated over 100 of their own patients with ... to provide the highest level of care for their patients. , The veterinarians ...
(Date:5/20/2016)... ... May 20, 2016 , ... Korean researchers say Manumycin ... may offer a new way to treat the disease. Surviving Mesothelioma has just posted ... , Scientists from several Korean institutions based their mesothelioma study on the fact the ...
Breaking Biology Technology: