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23andMe presents top 10 most interesting genetic findings of 2010
Date:1/12/2011

onnecting customers' genetics to the latest research in pharmacogenomics, 23andMe is actively researching the genetic basis underlying differences in individuals' responses to drugs. As the year drew to a close, 23andMe announced that, with funding from the National Institutes of Health, it is launching a multi-part pharmacogenomic research project. The first phase of the project will attempt to replicate known genetic effects that influence the efficacy and tolerability of three classes of medications: Warfarin, a commonly prescribed blood thinner; proton pump inhibitors, the most frequently prescribed medications for acid reflux; and nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, ibuprofen, and naproxen.

In 2007 and again in 2010, the FDA updated the labeling for warfarin to include information about how variations in two genes, CYP2C9 and VKORC1, can impact a patient's optimal dose of the drug. The latest update provided initial dosage recommendations for patients with different variant combinations. Studies are ongoing to determine the cost-benefits of using genetic testing to improve drug dosing; the results of such studies will influence whether and how quickly personal genetic information becomes a routine part of medical care. In August, The Spittoon covered these developments with an in-depth perspective of the complicated history and potential future of pharmacogenomics.

"Health at 23andMe: When One Size Doesn't Fit All." Dec 14, 2010. The Spittoon. http://spittoon.23andme.com/2010/12/14/health-at-23andme-when-one-size-doesn%E2%80%99t-fit-all/

"23andMe Launches Its First NIH-Funded Study." Dec 16, 2010. The Spittoon. http://spittoon.23andme.com/2010/12/16/23andme-launches-first-national-ins
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Contact: Jane E. Rubinstein
jrubinstein@rubenstein.com
212-843-8287
23andMe Inc.
Source:Eurekalert  

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