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23andMe presents top 10 most interesting genetic findings of 2010
Date:1/12/2011

at is highly expressed in the brain and known to be important in processes that are disrupted by the plaques that form in the brains of people with Alzheimer's. Two of the genes near rs597668, BLOC1S3 and MARK4, encode brain proteins that are also involved in processes that are disrupted in Alzheimer's disease. The MARK4 protein in particular is interesting because it interacts with tau, the protein responsible for the tangles seen in the brains of people with Alzheimer's.

Although risk models that incorporated an individual's information for the two replicated CLU and PICALM gene regions did not substantially improve prediction compared to a traditional model using only APOE status, age and sex, Nancy Pedersen of the Karolinska Institute in Sweden, points out in an accompanying editorial that this finding is not surprising given the small effect of these SNPs on risk and "only verifies the notion that AD is a polygenic disorder; i.e., that potentially tens of thousands of risk alleles, each with a small effect, are important for liability to disease. What is remarkable is that the single gene APOE is as important as it is for this complex disorder, and that right now, the most important thing doctors can do is encourage people to make lifestyle changes, especially those that improve cardiovascular health, that may reduce the risk of dementia or at least postpone it."

"SNPwatch: Large Study Identifies Two More Genetic Variants Associated with Alzheimer's Disease." May 11, 2010. The Spittoon. http://spittoon.23andme.com/2010/05/11/snpwatch-large-study-identifies-two-more-genetic-variants-associated-with-alzheimers-disease/

"SNPwatch: Largest Alzheimer's Genetic Studies To Date Identify Three New Susceptibility Genes." Sep 8, 2009. The Spittoon.

Contact: Jane E. Rubinstein
jrubinstein@rubenstein.com
212-843-8287
23andMe Inc.
Source:Eurekalert  

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