This year, SNPwatch presented a pair of studies published in Nature Genetics which found several new genetic variants associated with rheumatoid arthritis. A research team in Japan at the RIKEN Center for Genomic Medicine identified a variant, rs3093024, associated with rheumatoid arthritis risk in Japanese individuals. The second study, from Brigham and Women's Hospital in Boston, confirmed the same association in individuals with European ancestry. In both studies, each copy of the A version of the variant increased an individual's odds of the disease by 1.1 to 1.2 times.
The RIKEN team demonstrated that the different versions of rs3093024, already connected to risk of Crohn's disease, affect the behavior of the CCR6 gene, providing a potential biological explanation for the variant's contribution to rheumatoid arthritis risk. The Brigham and Women's team also found several other genomic regions associated with rheumatoid arthritis in people with European ancestry, some of which had not yet been linked to autoimmune disease.
"SNPwatch: Two Studies Connect More Immune System Genes to Rheumatoid Arthritis." May 12, 2010. The Spittoon. http://spittoon.23andme.com/2010/05/12/snpwatch-two-studies-connect-more-immune-system-genes-to-rheumatoid-arthritis/
Kochi Y et al. (2010) A regulatory variant in CCR6 is associated with rheumatoid arthri
|Contact: Jane E. Rubinstein|