The two studies' findings could lead eventually to the development of new types of treatments for childhood asthma. Previous research linking genetic variants on chromosome 17 with the risk for childhood asthma in Europeans suggested that these variants have an effect only in children who are exposed to tobacco smoke. More research will be needed to work out the details, but the importance of chromosome 17 in asthma was further supported by both of the current studies, which replicated the previous findings in addition to identifying new variants associated with the disease.
"SNPwatch: Breath Easier... New Insights From Asthma Research." Oct 26, 2010. The Spittoon. http://spittoon.23andme.com/2010/10/26/snpwatch-breathe-easier-new-insights-from-asthma-research/
"SNPwatch: More Progress in the Search for Genetic Variants Linked to Childhood Asthma." Jan 25, 2010. The Spittoon. http://spittoon.23andme.com/2010/01/25/snpwatch-more-progress-in-the-search-for-genetic-variants-linked-to-childhood-asthma/
Sleiman PA et al. (2010) Variants of DENND1B Associated with Asthma in Children. New Eng J Med. 362:36-44.
Moffatt MF et al. (2010) A Large-Scale, Consortium-Based Genomewide Association Study of Asthma. New Eng J Med. 363: 1211-1221.
3. New Variants Influence Risk for Rheumatoid Arthritis
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