Heid IM et al. (2010) Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet. 42:949-960.
2. Genetic variations newly associated with risk for childhood asthma
New regions of the genome associated with childhood asthma, a growing public health concern throughout the US affecting more than seven million children, were found by researchers from the Center for Applied Genomics at The Children's Hospital of Philadelphia (CHOP) and the GABRIEL consortium, as published in two studies in the New England Journal of Medicine. In the first study, analysis of DNA from about 1,700 children with asthma and 3,500 controls, all of European ancestry, identified several genetic variants on chromosome 1 associated with the risk of developing childhood asthma. Many of these same variants were then also found to be associated with risk for asthma in a sample of more than 1,600 African American children with asthma and 2,045 controls. All of the newly identified variants are located near the gene that encodes DENND1B, a protein known to be involved in the body's response to foreign particles.
The chromosome 1 variants identified by the CHOP researchers affected the odds of childhood asthma in different ways depending on ethnicity. Versions of the SNPs associated with increased risk in African Americans were associated with decreased risk in the European sample. This is not unusual in genetic studies, and often reflects differences in the genetic backgrounds of different populations.
In the second study, researchers identified associations between variants on chromosomes 2, 6, 9, 15, and 22 and asthma in individuals with European ancestry, with stronger effects for childhood asthma. They also observed that a pr
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