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23andMe presents top 10 most interesting genetic findings of 2010
Date:1/12/2011

titutes-of-health-funded-study/

"FDA Updates Label for Commonly Used Blood Thinner to Include Dosing Recommendations Based on Genetics." Feb 4, 2010. The Spittoon. http://spittoon.23andme.com/2010/02/04/fda-updates-label-on-commonly-used-blood-thinner-to-include-dosing-recommendations-based-on-genetics/

"Pharmacogenetics: The Long Road From Bench To Bedside." Aug 17, 2010. The Spittoon. http://spittoon.23andme.com/2010/08/17/pharmacogenetics-the-long-road-from-bench-to-bedside/

6. No clue yet to how long Geri-Boomers can expect to live

As the first baby boomers begin to turn 65 and qualify for Medicare, 23andMe reflected on a genome-wide association study of extreme longevity published this year in the journal Science which received a lot of press attention. At first glance the results appeared quite extraordinary: the authors identified 70 loci with genome-wide significant evidence for association with living past the age of 100, and they constructed a SNP-based model for predicting exceptional longevity that had 77% accuracy in an independent set of individuals. However, a closer reading by 23andMe pointed to some of the pitfalls in analyses of genome-wide datasets.

23andMe found several reasons for skepticism about the results. Another genome-wide study reported no significant associations with longevity, suggesting there may have been genotyping quality control problems in the new results, and some routine quality control checks did not appear to have been done. In addition, a preliminary analysis of the proposed 150-SNP model for predicting longevity indicated that it is not predictive in the 23andMe community.

23andMe expects that most o
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Contact: Jane E. Rubinstein
jrubinstein@rubenstein.com
212-843-8287
23andMe Inc.
Source:Eurekalert  

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