Navigation Links
23andMe identifies multiple genetic factors impacting development of nearsightedness

Mountain View, Calif. March 14, 2013 In the largest ever genome-wide association study on myopia, 23andMe, the leading personal genetics company, identified 20 new genetic associations for myopia, or nearsightedness. The company also replicated two known associations in the study, which was specific to individuals of European ancestry. The study included an analysis of genetic data and survey responses from more than 50,000 23andMe customers and demonstrates that the genetic basis of myopia is complex and affected by multiple genes.

Myopia is the most common eye disorder worldwide. In the United States, an estimated 30 to 40 percent of the adult population is nearsighted. Myopia is a refractive error that results primarily from increased axial length of the eye. The increased physical length of the eye relative to optical length causes images to be focused in front of the retina, resulting in blurred distance vision.

The study, titled "Genome-Wide Analysis Points to Roles for Extracellular Matrix Remodeling, the Visual Cycle, and Neuronal Development in Myopia" was published on February 28, 2013 in PLOS Genetics, an open-access, peer-reviewed journal.

Although environmental factors (such as level of education, outdoor exposure, reading, and "near work" or fine detail work that requires close focus of the eyes) are implicated in the development of myopia, it is well established that genetics play a substantial role as well. The identification of these 20 novel genetic associations shows that several new genetic pathways play a role in the development of human myopia, including extracellular remodeling, the visual cycle, eye and body growth, retinal neuron development and general neuronal development or signaling.

"This study highlights the potential importance of early neuronal development in the progression of myopia and opens the door for additional research into the complex interactions that underlie vision development," said Nicholas Eriksson, Ph.D., author and 23andMe principal scientist.

Based on the findings of this study, 23andMe has launched a new research survey designed to provide insights that may expand understanding of the genetics of eyesight more broadly.


Contact: Kendra Brogden
23andMe Inc.

Related biology news :

1. 23andMes Ancestry Composition reveals peoples ancestral origins going back 500+ years
2. 23andMe scientists receive more than $500,000 in National Institutes of Health funding
3. 23andMe Names Christine Castro, Neil Rothstein and Jonathan Ward to Leadership Positions
4. 23andMe opens its API to developers
5. 23andMe contributes to genetic discoveries related to male pattern baldness
6. 23andMe identifies 5 significant genetic associations for hypothyroidism
7. Sleator lab identifies single point mutation in Listeria monocytogenes
8. Genome-wide imaging study identifies new gene associated with Alzheimers plaques
9. Study identifies liver gene that regulates cholesterol and fat blood levels
10. La Jolla Institute identifies molecular switch enabling immune cells to better fight disease
11. New study identifies significance of co-infection in disease control
Post Your Comments:
(Date:9/29/2015)... 2015  iDAvatars is excited to be named one of ... market. The official announcement was recently made at an invite-only ... San Francisco , where iDAvatars presented a ... Watson. "It is both an honor and a ... bring to market the cognitive power of IBM Watson in ...
(Date:9/28/2015)... SAN JOSE, Calif. , Sept. 28, 2015 /PRNewswire/ ... developer of human interface solutions, today announced that Lenovo ... area touch fingerprint sensor, FS4202, for its latest smartphone, ... enables secure, password-free access to unlock the device and ... consumers. The feature-rich Natural ID FS4202 ...
(Date:9/10/2015)... Sept. 10, 2015 Report Details ... Reveals Selling Opportunities and Revenue Prospects to Help ... of biologics, especially new drug classes? Get the ... ahead with exclusive market data and industry knowledge, ... developments, results, opportunities and sales predictions. Visiongain,s ...
Breaking Biology News(10 mins):
(Date:10/12/2015)... ... 12, 2015 , ... Spirax Sarco, the leader in products and services for ... compact clean steam generator . This unit is a skid mounted system that ... and EN285 standards. The CMS-C 600 generator can produce up to a maximum ...
(Date:10/12/2015)... -- cell surface marker detection market is ... a new report by Grand View Research, Inc. This growth ... oncology diseases and other cell-associated disorders. --> cell ... 6.49 billion by 2022, according to a new report by ... attributed to rise in incidence of oncology diseases and other ...
(Date:10/12/2015)... CAESAREA, Israel , October 12, 2015 ... of the Dario™ Diabetes Management Solution, today announced its ... a patient case study at MobiHealth,s 5th EAI ... Focused on, "Transforming healthcare through innovations in mobile and ... London, England from October 14 - ...
(Date:10/12/2015)... ... 12, 2015 , ... NeuMedics Inc., is a specialty biopharmaceutical company focused on ... and chronically be administered as an eye drop, announced today it has been selected ... and taking place October 25th to October 28th at The Cleveland Clinic, Cleveland, Ohio. ...
Breaking Biology Technology: