Navigation Links
23andMe identifies 5 significant genetic associations for hypothyroidism
Date:4/9/2012

MOUNTAIN VIEW, CA (April 6, 2012) Using its unique online research platform, 23andMe, a leading personal genetics company, has found five significant genetic associations for hypothyroidism in the largest known genome-wide association study of hypothyroidism conducted to date. The details of the study are now available online in the journal PLoS ONE.

"With nearly 90 percent of our 125,000 customers participating in our online research, 23andMe is making crowd-sourced science a reality," stated 23andMe CEO and co-founder Anne Wojcicki. "Our online research platform continues to advance research faster and more cost effectively than traditional research models," added Wojcicki.

Of the five significant associations reported in this study, three are known to be involved in other autoimmune diseases. These include rs6679677 near PTPN22, rs3184504 in SH2B3, and rs2517532 in the HLA class I region. The other two associations reported here are rs4915077 near VAV3 and rs925489 near FOXE1, a gene involved in thyroid development. In addition, 23andMe observed associations with two loci marginally associated with hypothyroidism that have been linked to Thyroid Stimulating Hormone (TSH) levels, PDE8B and CAPZB as well as another gene previously associated with hypothyroidism and autoimmune disease (CTLA4).

"These genetic associations contribute significantly to understanding the underlying biology of hypothyroidism, which impacts five percent of the general population," remarked 23andMe Medical Director and study co-author Dr. Uta Francke. "Identification of associations with other autoimmune disorders opens up potential pathways of treatment."

Upon identification of those novel genetic associations for hypothyroidism also associated with autoimmune diseases, the 23andMe research team looked for any additional single-nucleotide polymorphisms (SNPs) shared with other autoimmune diseases, investigating a list of 107 SNPs that were studied across seven autoimmune diseases. Among this list, only the CTLA4, PTPN22, and SH2B3 loci show significant association with hypothyroidism.

According to 23andMe Principle Scientist and Lead Author Nicholas Eriksson, Ph.D., "These findings shed new light on the biology of hypothyroidism, showing that genes involved with both thyroid function and immune response impact this disease. This demonstrates our ability to harness the power of the enormous 23andMe genetic database to further medical research.

This study investigated 3,736 individuals with hypothyroidism as well as 35,546 controls, all drawn from the more than 100,000 23andMe customers who have consented to participate in research efforts. Cases included individuals who have been diagnosed with hypothyroidism, have elevated TSH levels, or are taking thyroid hormone replacement medication.

These results continue to validate 23andMe's methodology in combining self-reported data on phenotypes gathered via web-based questionnaires and genotypic data derived from self-collected saliva samples. 23andMe had previously published its first proof-of-concept results in the journal PLoS Genetics in June 2010 which reported novel associations for unusual traits such as asparagus anosmia and photic sneeze reflex and replicated associations for other common genetic traits, and recently published the discovery of two novel genetic associations for Parkinson's disease in PLoS Genetics, and presented a major replication study of over 180 genetic associations in the journal PLoS ONE in August 2011.


'/>"/>
Contact: Jane E. Rubinstein
jrubinstein@rubenstein.com
212-843-8287
23andMe Inc.
Source:Eurekalert  

Related biology news :

1. Cleveland Clinic joins 23andMe in the search for genetic clues to Parkinsons disease
2. 23andMe replicates over 180 genetic associations with Web-based research platform
3. 23andMe sarcoma research community reaches 500 and announces Sarcoma Scientific Advisory Committee
4. 23andMe presents top 10 most interesting genetic findings of 2010
5. 23andMe receives NIH funding to evaluate web-based research on the genetics of drug response
6. Plant DNA speaks English, identifies new species
7. Leatherback turtle migration study identifies Pacific danger zones for endangered species
8. LSUSHC research identifies new experimental drug for stroke
9. 3-year study identifies key interventions to reduce maternal, newborn and child deaths
10. Study identifies mechanisms cells use to remove bits of RNA from DNA strands
11. UIC study identifies a key molecular switch for telomere extension by telomerase
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
23andMe identifies 5 significant genetic associations for hypothyroidism
(Date:6/16/2016)... 2016 The global ... reach USD 1.83 billion by 2024, according to ... Technological proliferation and increasing demand in commercial buildings, ... drive the market growth.      (Logo: ... development of advanced multimodal techniques for biometric authentication ...
(Date:6/9/2016)... in attendance control systems is proud to announce the introduction of fingerprint attendance control ... right employees are actually signing in, and to even control the opening of doors. ... ... ... Photo - ...
(Date:6/7/2016)... , June 7, 2016  Syngrafii Inc. ... a business relationship that includes integrating Syngrafii,s patented ... branch project. This collaboration will result in greater ... the credit union, while maintaining existing document workflow ... http://photos.prnewswire.com/prnh/20160606/375871LOGO ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June 23, 2016 A person commits a ... crime scene to track the criminal down. An ... Food and Drug Administration (FDA) uses DNA evidence to track ... Sound far-fetched? It,s not. The FDA has increasingly ... support investigations of foodborne illnesses. Put as simply as possible, ...
(Date:6/23/2016)... 23, 2016   EpiBiome , a precision microbiome ... in debt financing from Silicon Valley Bank (SVB). The ... to advance its drug development efforts, as well as ... "SVB has been an incredible strategic partner to ... traditional bank would provide," said Dr. Aeron Tynes ...
(Date:6/23/2016)...  Blueprint Bio, a company dedicated to identifying, protecting ... has closed its Series A funding round, according to ... "We have received a commitment from Forentis Fund that ... meet our current goals," stated Matthew Nunez . ... complete validation on the current projects in our pipeline, ...
(Date:6/23/2016)... ... June 23, 2016 , ... Velocity Products, a division of ... and optimized exclusively for Okuma CNC machining centers at The International Manufacturing Technology ... among several companies with expertise in toolholding, cutting tools, machining dynamics and distribution, ...
Breaking Biology Technology: