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22nd Congress of the European College of Neuropsychopharmacology, Sept. 12-16, 2009, Turkey
Date:7/10/2009

c therapeutic agents to regulate the biological mechanisms of mental disorders, i.e. the neuronal interactions that give rise to these disorders. For this purpose, neuropsychopharmacology investigates the effect of drugs on the central nervous system (CNS) and their use in treating disorders such as anxiety, mania, depression, schizophrenia, dementia or neurological and addictive disorders in the most rational and empirical manner.

Neuropsychopharmacological research provides data that are required to develop drugs, which act on specific receptors within a neurotransmitter system. The pharmacological progress achieved in recent decades is mainly due to the development of receptor-specific drugs. For instance, the currently most commonly used antidepressant drugs, the SSRIs, selectively inhibit the transport of the neurotransmitter serotonin, prolonging its activity in the synapse between the nerve cells. In the next step, the development of receptor subtype-specific drugs is currently encouraged. So-called hyperselective drugs are thought to allow the direct targeting of specific sites of relevant neural activity, thereby maximising the efficacy of the drug within the clinical target and minimising adverse events. For instance, the signalling of serotonin is mediated by 14 receptor subtypes. As one of the main mediators of the neurotransmitter action the serotonin (1A) subtype is of particular interest, since evidence indicates that it is a target for novel therapeutic advances in several neuropsychiatric disorders (gren et al., 2008). Furthermore, cognitive and neural mechanisms involved in emotion processing can be manipulated pharmacologically, and research continues to identify novel targets for anxiolytic drugs (Garner et al., 2009).

New developments in neuropsychopharmacology may lead to targeted treatment options for a wide variety of mental disorders.

European College of Neuropsychopharmacology (ECNP)

The Europ
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Contact: Sonja Mak
s.mak@update.europe.at
431-405-5734
European College of Neuropsychopharmacology
Source:Eurekalert

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