Navigation Links
2020 vision of vaccines for malaria, TB and HIV/AIDS
Date:5/25/2011

parts alone. "The power of systems biology comes from its capacity to predict the behavior of an entire biological system," Aderem said. "From there, we can optimize vaccine candidates and predict whether a drug or vaccine candidate can work before it moves into large scale, very expensive clinical trials."

Systems biology can also be used to speed the often lengthy clinical trial experience. Aderem and Rappuoli estimate that in trials of new vaccines for malaria, TB and HIV/AIDS, only one hypothesis has been tested every eight years in the past three decades. "We cannot afford this approach if we want to have an impact on disease in a reasonable timeframe," Aderem said. "We can accelerate clinical development by performing more efficacy trials and by improving their design using systems biology approaches to test several hypotheses in parallel and having an adaptive design to expand the outcomes that prove most promising."

Aderem and Rappuoli also debunk one of the key criticisms of systems biology that it is overly reliant on computation. "Much of this comes from a misunderstanding on the role of computers in systems biology," Aderem explained. "Computers are not expected to come up with biological insights from the outset, but are meant to facilitate an integration of discovery science with hypothesis-driven science to yield a holistic description of a biological system."

While progress has been made over the past few years in the development of novel vaccines against the three most challenging infectious diseases in the world, Aderem and Rappuoli conclude that innovative design of clinical trials, testing several vaccines in parallel and getting early information using systems biology approaches will accelerate vaccine development and increase understanding of the human immune system.


'/>"/>

Contact: Jennifer Mortensen
jennifer.mortensen@seattlebiomed.org
206-256-7220
Seattle Biomedical Research Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. LIAI launches new division to look at novel approaches to heart disease and inflammation
2. Rong Li Lab probes mechanism of asymmetry in meiotic cell division
3. Gene therapy restores vision to mice with retinal degeneration
4. New cell division mechanism discovered
5. The bonsai effect: Wounded plants make jasmonates, inhibiting cell division, stunting growth
6. NYU biologist Bonneau named among 20 "visionary" scientists under 40 by Discover magazine
7. Proteins strangle cell during division
8. Billion-year revision of plant evolution timeline may stem from discovery of lignin in seaweed
9. TECNALIA uses artificial vision to improve recycling of electronic scrap metal
10. Scientists deconstruct cell division
11. Cells with double vision
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... January 22, 2015 , ... The European Patent Office to present a video retrospective ... nominations to be featured: Christofer Toumazou and Sophie ... finalists and winners of the Award   Starting on ...
(Date:1/22/2015)... has launched its new NXG series of time clocks with ... higher standard for collecting attendance and labor data and complements ... touch screen interface and seamless connection to cloud-based iSolved, the ... for the small to mid-size employer. The G2 ...
(Date:12/22/2014)... and Markets ( http://www.researchandmarkets.com/research/fx4bg3/the_global ) has ... Watermarking and Fingerprinting Markets" report to their ... This insight provides an overview of ... Watermarking aims to control and monitor piracy by ...
Breaking Biology News(10 mins):Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 2Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 3Infinisource's NXG series sets new time clock standard 2The Global Watermarking and Fingerprinting Markets 2
... before. Whether it,s the death of a physically fit high school ... woman gardening in the middle of the day in July, heat ... treatment beyond submersion in ice water or the application of ice ... But, in a new study published today in the journal ...
... The decade from 2000 to 2009 was the warmest ... studies have shown evidence of changes in mountain plant ... yet taken a continental-scale view of the situation ... of mountain vegetation to climate change," scheduled for Advance ...
... this month, Biology of Reproduction is shifting its ... in Press production will remain unchanged for the time ... www.biolreprod.org as they are completed, rather than being ... the versions of record. At the end of each month, ...
Cached Biology News:'Couch potato pill' might stop heat stroke too 2'Couch potato pill' might stop heat stroke too 3European mountain vegetation shows effects of warmer climate 2
(Date:12/24/2014)... and NEW YORK , Dec. 24, 2014 ... advancing patient care in critical areas, announced the closing of ... and warrants to purchase up to an aggregate 3,500,000 shares ... share and $.01 per warrant.  The warrants have a per ...
(Date:12/24/2014)... “Preparative & Process Chromatography Market by Instrument ... Buffers, Valves, Guages, Seals), Accessories, Services, End User ... 2019” provides a detailed overview of the major ... strategies impacting the preparative and process chromatography market ...
(Date:12/24/2014)... (PRWEB) December 23, 2014 ... designed to introduce cutting edge communication technology, provide ... platform upgrades. This webinar series demonstrates online communication ... to leverage web conferencing’s most innovative and powerful ...
(Date:12/24/2014)... 2014 The report provides basic ... classification, application and industry overview. This report also ... structure. Production is separated by regions, technology and ... equipment, downstream client survey, marketing channels, industry development ...
Breaking Biology Technology:PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3Worldwide Methyl Mercaptan Market 2015-2020 Forecasts on Development & Trends Now Available at ReportsnReports.com 2
... ... Real-time in situ FTIR analysis has become a standard tool in the ... more thorough understanding of reactions during the development and scale-up of chemical ... of Batch and Continuous Chemical Processes Using Real-Time In Situ FTIR Analytics ...
... Clarient, Inc. (Nasdaq: ... resource for pathologists, oncologists and the pharmaceutical industry, today reported ... September 30, 2009. Results included a 13 percent increase ... compared to the third quarter of 2008. Third quarter ...
... ... Physics and Biology are Natural Partners in the Fight Against Disorder. , ... (PRWEB) November 3, 2009 -- ... Cushion that naturally relieves osteoarthritis without causing unwanted side-effects, is now available online at ...
Cached Biology Technology:Development of Batch and Continuous Chemical Processes Using Real-Time In Situ FTIR Analytics as a Process Analytical Technology (PAT) Tool 2Clarient Reports 2009 Third Quarter; Nine Month Results 2Clarient Reports 2009 Third Quarter; Nine Month Results 3Clarient Reports 2009 Third Quarter; Nine Month Results 4Clarient Reports 2009 Third Quarter; Nine Month Results 5Clarient Reports 2009 Third Quarter; Nine Month Results 6Clarient Reports 2009 Third Quarter; Nine Month Results 7Clarient Reports 2009 Third Quarter; Nine Month Results 8Clarient Reports 2009 Third Quarter; Nine Month Results 9Clarient Reports 2009 Third Quarter; Nine Month Results 10Clarient Reports 2009 Third Quarter; Nine Month Results 11New Technology Now Available In Canada For Osteoarthritis 2
Mouse monoclonal antibody raised against a partial recombinant TPR. NCBI Entrez Gene ID = TPR...
... array sample elements. , , ,Includes: , , ... in PBS (10X): 50 ml , Streptavidin ... 8 packs , 10% Tween-20: 2 x 10 ... x 25 ml , SuperSignal West Pico Stable Peroxide: ...
... The Partec Cell Counter Analyser counts ... that the CCA detects only cells, so ... influence the results.,While passing through a 250 ... a fluorescence light signal which is used ...
... Clean and Accurate Results Laser Capture ... the sensitivity and accuracy of molecular assays ... types and multi-cellular structures isolated from whole ... to microdissection-developed in 1996 at the National ...
Biology Products: