The award Chakraborty was honored with during the plenary highlighted his research for the High Throughput Pan-omic Approaches to Study the Effect of Microgravity on Responses of Skin Endothelial Cells to Insult (STL-MRMC) investigation. This study looked at cell and tissue cultures aboard the space station to examine the host-pathogen relationship and wound healing in space. Humans' healing processes behave differently in this environment where the body's efforts to repair itself are compounded by its compromised defense mechanism and more aggressive pathogen productions.
"In this context, we thought our integrative system biology expertise would be a valuable tool for investigating this multilayered health issue. And, we are elated to see that NASA shares our viewpoints and values our work," said Chakraborty. "This award is a great motivation and will help us remain committed to finding the solutions specific to the extraterrestrial environments. In fact, we are all set to get involved in the upcoming spaceflights purposed for [researching] mouse models (in vivo) and cellular components (in vitro) meeting similar missions."
On Earth, research into wound healing and immunology remains a challenge, according to Chakraborty, making the findings from his work in orbit of particular interest for human health on the ground, given the life-threatening risks infection can carry. "The molecular information mined from the project, particularly from its ground control study, could be significantly beneficial to the terrestrial health research," said Chakraborty. "Present data also suggests some potential biomarkers with clinical significance. Additional studies are underway to better understand the process, to apply the knowledge to other related health issues and to translate the knowledge to the discovery of more viable biomarkers."
The Integrated Cardiovascular (ICV) study looks at cardiac fun
|Contact: Laura Niles|
NASA/Johnson Space Center