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2010 AAO-HNSF new research daily highlights: Sunday, Sept. 26, 2010
Date:9/26/2010

nual Meeting & OTO EXPO in Boston, researchers revealed the first study to systematically use OCT to differentiate thyroid and parathyroid glands from other structures in the neck. OCT can be used to evaluate these structures, which can be then confirmed with histopathologic evaluation via frozen or permanent sections.


PTPN13 Expression Correlates with Survival in HPV, HNSCC
Presenters: George Harris, MD; Aaron Bossler, MD, PhD
Time: 11:32 am
Location: Room 259

Boston, MA The human papillomavirus (HPV) oncogene E6 has been shown to perform multiple functions (p53 degradation, telomerase activation, etc.) that play a role in oncogenic transformation. Beyond known E6 functions, a recently defined mechanism that allows cellular invasion requires the E6 PDZ binding motif (PDZBM) to induce loss of a protein tyrosine phosphatase (PTPN13) in a PDZBM-dependent manner.

In a presentation at the 2010 AAO-HNSF Annual Meeting & OTO EXPO in Boston, researchers revealed that patients who develop HNSCC associated with HPV, without the additional genetic hit associated with abnormal PTPN13, have improved survival, possibly related to fewer genetic changes. Analyzing PTPN13 status in HPV-positive HNSCC may identify those patients who will have better survival, or conversely, those patients who may require additional treatment.


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Contact: Mary Stewart
mstewart@entnet.org
703-535-3762
American Academy of Otolaryngology -- Head and Neck Surgery
Source:Eurekalert

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