Navigation Links
2-way traffic enable proteins to get where needed, avoid disease
Date:11/25/2013

or that could go in the opposite direction, delivery, or localization, of the cargo mRNA already en-route was compromised.

"What we have seen is that there are many things that can reverse that track," Gonsalvez said. "If they can only go in one direction, they can bump into something, like a stray organelle, and get stuck."

Motor proteins have long been known to haul mRNA up and down the cell's cytoskeleton, which essentially functions as an internal roadway for the cell. Gonsalvez recently received a $1.4 million grant from the National Institutes of Health to fill in other important knowledge gaps about the journey, like how the motor proteins know which mRNA to transport, because not all mRNA needs to be localized.

He likens the routing system to a ZIP code and thinks proteins are again key, but in this case, they are bound to the mRNA, flagging it for travel. "Something is telling the cell that this message is different," he said.

In the case of Fragile X syndrome, for example, he suspects that one or more proteins that should be bound to mRNA are missing so the cell can't tell the messenger it needs to be moved.

Another question Gonsalvez wants to answer is how mRNA holds on for the ride since the motor protein won't bind with it directly.

"These are not easy questions but the thought is once we understand the answers, we will understand why, when you have a defect in this process, you have a disease pathology," Gonsalvez said.

He notes that transportation of mRNA occurs lifelong, since proteins have a limited life and are constantly being replaced.

His research model is the comparatively simple fruit fly in which the technology is available to selectively knock out motor proteins in specific cells. His published research was funded by the American Cancer Society and the NIH.


'/>"/>

Contact: Toni Baker
tbaker@gru.edu
706-721-4421
Medical College of Georgia at Georgia Regents University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Molecular 2-way radio directs nerve cell branching and connectivity
2. Reducing traffic at 2008 Olympics yielded large cut in CO2
3. Symbols, such as traffic lights, on menus effective in educating diners
4. A new method for measuring the flow of traffic a street has to bear by measuring atmospheric noise
5. Long-term exposure to fine particles of traffic pollution increases risk of heart disease
6. Neurochemical traffic signals may open new avenues for the treatment of schizophrenia
7. Gene decoding obeys road traffic rules
8. Traffic pollution and wood smoke increases asthma in adults
9. Home cooking, traffic are sources of key air pollutants from China
10. USC scientists ID protein that regulates cellular trafficking, potential for anti-cancer therapy
11. Protein explains increased asthma severity in children exposed to diesel exhaust from traffic
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
2-way traffic enable proteins to get where needed, avoid disease
(Date:7/30/2015)... , July 30, 2015 Cellecta, Inc., ... gene function analysis and biomarker discovery, announced the ... Knockout Library targeting all human protein coding genes. ... "knock out" a gene,s function. Cellecta,s new Human ... throughput screening tool so that researchers can investigate ...
(Date:7/21/2015)... Sweden , July 21, 2015 Today, ... FPC1025. Already received as well as expected revenues in 2015 that ... in FPC,s communicated revenue guidance of approximately 2,200 MSEK for 2015. ... is a leading smartphone manufacturer in China ... selected FPC1 02 5 for Axon ...
(Date:7/13/2015)... Jul. 13, 2015 NXT-ID, Inc. (NASDAQ: ... authentication company focused on the growing mobile commerce ... patent 62/188684 for BEHAVIORAL-DIRECTED AUTHENTIATION METHOD ... convenient and secure method to make payments.  With ... methods, introduced with its groundbreaking voice-direct payment patent ...
Breaking Biology News(10 mins):CELLECTA, INC. Announces Launch of Human Whole Genome CRISPR Knockout Library 2FPC's Touch Fingerprint Sensor FPC1025 in ZTE's Smartphone Axon 2NXT-ID Patents Behavior-Directed Payments 2NXT-ID Patents Behavior-Directed Payments 3NXT-ID Patents Behavior-Directed Payments 4
... can lead to cellular changes in the cervix that ... of these pre-stages gives an increased risk of preterm ... pre-stages of cervical cancer, it may therefore reduce the ... calculated the benefits of HPV-vaccination. Cervical cancer ...
... Alexandria, Va. The 2009 Wilmer Souder Award is ... of,Colorado, Aurora, USA. The International Association for Dental Research ... & Exhibition in Miami, Florida, USA, on April 1, ... of Craniofacial Biology at the University of Colorado School ...
... of The Proceedings of the National Academy of Sciences ... "alpha-synuclein dance" the switching back and forth of the ... the surface that it is binding to changes. Such ... like alpha-synuclein, which are known to be unfolded in isolation, ...
Cached Biology News:HPV vaccine may prevent preterm births 2Scripps research scientists 'watch' as individual alpha-synuclein proteins change shape 2Scripps research scientists 'watch' as individual alpha-synuclein proteins change shape 3
(Date:7/30/2015)... HIGHLIGHTS:Q2 2015 Results (all changes are against the ... $697 million compared to $701 million in the second ... changes in foreign currency exchange rates decreased sales by ... By business unit, organic sales growth was 6% in ... , Reported diluted EPS was $0.98 compared to ...
(Date:7/30/2015)... ... 30, 2015 , ... As part of its 2015 growth plan and as a follow up ... business units, Whitehouse Laboratories is pleased to announce that it has begun construction on ... of Excellence and will be strictly dedicated to basic USP 51, USP 61, and USP ...
(Date:7/29/2015)... Sanofi, a global and ... quarter of 2015. CEO Olivier Brandicourt ... in different businesses. Watch video interview ... Topics covered in the interview include:  ... Performance drivers - Diabetes ...
(Date:7/29/2015)... BANGALORE , July 30, 2015 ... Cell Market - Growth, Trends & Forecasts (2015-2020), , published ... worth US$ 30.25 billion by the end of 2020, with ... globally accounting for more than 40% of the global market ... grow at a CAGR of 13.7% during the period of ...
Breaking Biology Technology:Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 2Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 3Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 4Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 5Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 6Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 7Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 8Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 9Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 10Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 11Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 12Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 13Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 14Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 15Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 16Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 17Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 18Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 19Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 20Whitehouse Labs Formally Announces Plans to Open a Microbiological Laboratory 2Asia Pacific to Dominate the Global Stem Cell Market - Vericel Corporation, Ocata Therpeutics, Athersys Inc., Cryo-Cell International, Geron Corporation, StemCells, Inc. Among the Major Players 2Asia Pacific to Dominate the Global Stem Cell Market - Vericel Corporation, Ocata Therpeutics, Athersys Inc., Cryo-Cell International, Geron Corporation, StemCells, Inc. Among the Major Players 3
... March 7, 2012 Karyopharm Therapeutics Inc., a leader ... nine presentations covering its Selective Inhibitors of Nuclear Export ... meeting on March 31 – April 4, 2012, in ... studying the use of Karyopharm,s novel SINE, along with ...
... Inc. (OTC/BB: PROT) announced today that it has ... to which the Company has agreed to sell shares ... aggregate purchase price of approximately $3.8 million (which are ... common stock) and Series A, Series B and Series ...
... NEW YORK, March 5, 2012  Organovo, Inc., (OTCQB: ... on using its breakthrough NovoGen 3D human tissue ... research and medical applications, today announced that their ... on-demand viewing. LINK:    www.retailinvestorconferences.com ...
Cached Biology Technology:Karyopharm Therapeutics Announces Multiple Presentations on Selective Inhibitors of Nuclear Export (SINE) in Solid and Hematologic Malignancy Models and Spontaneous Canine Cancers at the American Association of Cancer Research (AACR) Meeting 2Karyopharm Therapeutics Announces Multiple Presentations on Selective Inhibitors of Nuclear Export (SINE) in Solid and Hematologic Malignancy Models and Spontaneous Canine Cancers at the American Association of Cancer Research (AACR) Meeting 3Proteonomix Announces a Private Placement of $3.8 Million 2Proteonomix Announces a Private Placement of $3.8 Million 3Proteonomix Announces a Private Placement of $3.8 Million 4Organovo, Inc. Investor Presentation Now Available for On-Demand Viewing at RetailInvestorConferences.com 2
... different Cynomolgus monkey normal tissues are ... upon request. Customers can choose ... set, and pay 70% of the ... P Set products are for research ...
...
Immunogen: Recombinant full length protein, corresponding to amino acids 1-435 of Human AP2M1. Storage: -20 C, Avoid Freeze/Thaw Cycles...
cysteine and glycine-rich protein 2,...
Biology Products: