Navigation Links
2 players produce destructive cascade of diabetic retinopathy

Augusta, Ga. - The retina can be bombarded by reactive oxygen species in diabetes, prompting events that destroy healthy blood vessels, form leaky new ones and ruin vision.

Now researchers have learned that those chemically reactive molecules must come from both the bone marrow as well as the retinal cells themselves to cause such serious consequences.

"It's a cascade that requires two players to signal the next event that causes the damage," said Dr. Ruth Caldwell, cell biologist at the Vascular Biology Center at the Medical College of Georgia at Georgia Regents University.

The good news is the finding also provides two new points for intervention, said Dr. Modesto Rojas, MCG postdoctoral fellow and first author of the study in the journal PLOS ONE.

Excessive glucose in the blood prompts excessive production of reactive oxygen species, or ROS, and the light-sensitive retina is particularly vulnerable. Caldwell's research team had previously documented that ROS from white blood cells produced by the bone marrow as well as from retinal cells were the major instigators in diabetic retinopathy, a leading cause of blindness worldwide. But they weren't sure which mattered most.

So they looked as several different scenarios, including mice lacking the ability to produce ROS by either the retinal or white blood cells, and found that if either were lacking, future damage was essentially eliminated. "One alone can't do it," said Caldwell, the study's corresponding author. "They did not develop the early signs of diabetic retinopathy that we were measuring."

While blocking ROS production by retinal cells could be difficult, drugs already exist that reduce activation of white blood cells. Those cells not only make ROS, but also adhere to blood vessel walls in the retina that become sticky in diabetes, Rojas said. In fact, a study published in October 2013 in PLOS ONE showed that neutrophil inhibitory factor could block the vascular lesions that are a hallmark of diabetic retinopathy without hurting the immunity of diabetic mice. The MCG scientists note that decreased activation does not impact the immune protection white blood cells also provide.

Next steps include studying those drugs in their animal models and learning more about how ROS causes the collateral damage that can destroy vision. "All of this is some sort of wound-healing response gone wrong," Caldwell said.

ROS, a natural byproduct of the body's use of oxygen, has healthy roles in the body, including cell signaling, but is destructive at high levels that result from disease states such as diabetes.

Contact: Toni Baker
Medical College of Georgia at Georgia Regents University

Related biology news :

1. Measuring the exertion of mini-basketball players
2. Study discovers natural hybridization produced dolphin species
3. Gene therapy for human skin disease produces long-term benefits
4. How living cells solved a needle in a haystack problem to produce electrical signals
5. Hypersensitivity to pain produced by early life stress is worsened by later stress exposure
6. Breakthrough research produces brighter, more efficiently produced lighting
7. Small changes in ag practices could reduce produce-borne illness
8. TabletKiosk and SMI Collaborate to Produce the Sahara EyeSlate
9. Over-produced autism gene alters synapses, affects learning and behavior in mice
10. Bacteria use hydrogen, carbon dioxide to produce electricity
11. Neiker-Tecnalia and FARMARABA produce Omega 3 using marine plant micro-organisms
Post Your Comments:
Related Image:
2 players produce destructive cascade of diabetic retinopathy
(Date:11/17/2015)... Paris from 17 th until 19 th ... from 17 th until 19 th November 2015.   ... the first combined scanner in the world which scans both ... two different scanners were required: one for passports and one ... same surface. This innovation is an ideal solution for electronic ...
(Date:11/12/2015)... Nov. 12, 2015  A golden retriever that stayed ... dystrophy (DMD) has provided a new lead for treating ... the Broad Institute of MIT and Harvard and the ... . Cell, pinpoints a protective ... the disease,s effects. The Boston Children,s lab of ...
(Date:11/10/2015)... 2015 About signature verification ... to identify and verify the identity of an ... the secure and accurate method of authentication and ... individual because each individual,s signature is highly unique. ... dynamic signature of an individual is compared and ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... Malaysia , Nov. 24, 2015  Asia-Pacific ... contract research organisation (CRO) market. The trend of ... in lower margins but higher volume share for ... capacity and scale, however, margins in the CRO ... Organisation (CRO) Market ( ), finds ...
(Date:11/24/2015)... ... November 24, 2015 , ... Copper is an essential ... bound to proteins, copper is also toxic to cells. With a $1.3 million ... (WPI) will conduct a systematic study of copper in the bacteria Pseudomonas aeruginosa ...
(Date:11/24/2015)... PHILADELPIA, PA (PRWEB) , ... November 24, 2015 , ... ... young entrepreneurs at competitive events in five states to develop and pitch their BIG ... student projects from each state are competing for votes to win the title of ...
(Date:11/24/2015)... QUEBEC CITY , Nov. 24, 2015 /PRNewswire/ ... (the "Company") announced today that the remaining 11,000 ... Common Share Purchase Warrants (the "Series B Warrants") ... agreement were exercised on November 23, 2015, which ... Common Shares.  After giving effect to the issuance ...
Breaking Biology Technology: