Navigation Links
2 new therapies show promise for cancer patients
Date:4/15/2008

San Diego and PhoenixApril 15, 2008Clinical researchers at Scottsdale Healthcare and TGen today announced the results of two clinical trials that show promise for patients battling cancer.

The Phase I clinical trial findings, presented at the this weeks Annual Meeting of the American Association for Cancer Research by Daniel Von Hoff, MD, FACG, focused on basal cell carcinoma (BCC) and pancreatic cancer. The Arizona trials were conducted at TGen's Clinical Research Service (TCRS) at Scottsdale Healthcare, a strategic alliance between TGen and Scottsdale Healthcares Clinical Research Institute.

Basal Cell Carcinoma

In the first trial, a novel molecule, GDC-0449, shrinks tumors in basal cell carcinoma (BCC) while having limited side effects, including a loss of sense of taste, and a small amount of hair loss and weight loss, suggesting a viable new treatment option. GDC-0449 works by blocking a pathway a series of chemical reactions within a cell known as Hedgehog, containing two genes (PTCH and SMO) that lead to a known tumor-promoting gene called GLI1. Alterations in any of these genes have been shown to lead to basal cell carcinoma and other diseases. GDC-0449 is a chemical synthetic designed to replicate the properties of cyclopamine, a chemical found in nature.

Basal cell carcinoma affects about one million people a year and a proportion of these patients have disease that is not curable with surgery. We currently do not have any treatments that can effectively slow tumor growth in these advanced patients. This finding has potential importance in this population, said Daniel D. Von Hoff, M.D., Physician in Chief at the Translational Genomics Research Institute (TGen) and Chief Medical Officer for the Scottsdale Clinical Research Institute at Scottsdale Healthcare.

Typically diagnosed with a simple biopsy, the risk of BCC increases for those individuals with a family history, or prolonged exposure to ultr
'/>"/>

Contact: Galen Perry
gperry@tgen.org
602-343-8423
The Translational Genomics Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Linchpin gene may be useful target for new breast cancer therapies
2. NCI renewal grant to develop new cancer therapies
3. The construction of heart modelling leads path to new therapies
4. Challenges and promise of cell-based therapies
5. Innovative civil engineering application promises cleaner waters
6. New CPR promises better results by compressing abdomen, not Chest
7. Tiny tubes and rods show promise as catalysts, sunscreen
8. New genetic research into nicotine addiction shows promise for personalized treatment
9. Genetic ancestral testing cannot deliver on its promise, study warns
10. Sweet potato shines as new promise for small enterprise and hunger relief in developing countries
11. Summer-dormant tall fescue grass shows promise for pasture improvements
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2014)... New Rochelle, NY, April 24, 2014GEN Publishing recently ... semi-monthly digital publication focusing on the application of ... such as next-gen sequencing, are beginning to transform ... science research over the past decade-and-a-half. , "GEN,s ... use of pharmacogenomics, genomics, metabolomics, transcriptomics, etc. etc. ...
(Date:4/24/2014)... NY, April 24, 2014D-ribose is a commercially important ... and as a starting compound for synthesizing riboflavin ... Escherichia coli to increase the bacteria,s ability ... achieving more efficient industrial-scale production of this valuable ... Industrial Biotechnology , a peer-reviewed journal from Mary ...
(Date:4/24/2014)... the Scientific Reports journal. , CSIC researcher Carles ... of CSIC and Pompeu Fabra University-UPF), explains: "When the Y ... that it did not match with the DNA recovered from ... genome and to make a functional interpretation in order to ... , The functional genome analysis was based on two ...
Breaking Biology News(10 mins):The blood preserved in the pumpkin did not belong to Louis XVI 2
... German . , Mucosal epithelia do not have ... viruses like hepatitis C, herpes, the adenovirus or polio, and ... as the human immunodeficiency virus HIV, still manage to enter ... occurs on a molecular level has been a mystery. Three ...
... new study reveals how enzymes in the honey ... the honey bee hive. This is the first study to ... insect to tolerate exposure to these potentially deadly compounds. ... Academy of Sciences . Previous studies have shown that ...
... University of Minnesota Medical School and College of Biological ... sex must be maintained throughout life. The research team, ... U of M Department of Genetics, Cell Biology and Development, ... causes male cells in mouse testis to become female cells. ...
Cached Biology News:Scavenger cells accomplices to viruses 2Team shows how the honey bee tolerates some synthetic pesticides 2U of M researchers discover gene required to maintain male sex throughout life 2
(Date:1/14/2014)... January 14, 2014 EquitiesIQ, a leading ... (OTCQB: ALQA). Alliqua is an emerging biomedical company acquiring, ... wound care market. , Free report download: http://equitiesiq.com/reports/alliqua/ ... a seasoned management team and Board, which launched the ...
(Date:1/14/2014)... iLab Solutions, the leader in core facility ... of Product Strategy. In this role, Michelle will work with ... guide in the development of iLab products. Her main goal ... benefit to the scientific community by offering the most advanced, ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 Global ... developing innovative information technology solutions for patients, physicians, ... care stakeholders, announced today the signing of a ... Food and Drug Administration (FDA). This initiative ...
(Date:1/14/2014)... Kerr Corporation, a leading manufacturer of innovative dental products, ... dual arch impressions on its dental blog. , ... entry serves up a list of tips to help dentists ... Dr. David Little as he crafts a porcelain crown using ...
Breaking Biology Technology:EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2Global Record Systems Announces Research Collaboration Agreement with FDA to Create a Novel “Big Data” Paradigm for Collection of Patient Safety and Outcomes Information 2
... -- The Wisconsin Department of Commerce (Commerce) has ... the new Angel Investor and Venture Fund Tax Credit ... for investors and will help us attract qualified angels ... testing of our technology," said Larry Wells, CEO of ...
... CHICAGO As witnessed by the BIO 2005 meeting ... beyond its U.S. roots has really taken flight. The company ... & Young in its annual report on biotechnology. , ,This ... meeting. This years report, which carries the appropriate title Beyond ...
... Madison, Wis . - The average citizen may think Gov. ... Frazier whenever they step into the boxing ring of politics. ... taken place in the Capitol over the past two and ... correct. , ,Not entirely correct, however, as evidenced by some ...
Cached Biology Technology:Globalization of biotech industry is a decidedly worldwide phenomenon 2Globalization of biotech industry is a decidedly worldwide phenomenon 3State tax compromises prove that partisanship can be set aside for a while 2State tax compromises prove that partisanship can be set aside for a while 3
... are derived from Paraffin embedded tissue blocks, ... procedures to ensure the highest quality. Tissues ... one block, sectioned at a thickness of ... Sections are large (3-5 mm in diameter) ...
... are derived from Paraffin embedded tissue blocks, ... procedures to ensure the highest quality. Tissues ... one block, sectioned at a thickness of ... Sections are large (3-5 mm in diameter) ...
... derived from frozen embedded tissue blocks, which ... to ensure the highest quality. Tissues of ... block, sectioned at a thickness of 7microns ... large (3-5mm in diameter) in comparison to ...
... from frozen embedded tissue blocks, which are ... ensure the highest quality. Tissues of each ... sectioned at a thickness of 7microns and ... (3-5mm in diameter) in comparison to core ...
Biology Products: