Navigation Links
2 new genes linked to amyotrophic lateral sclerosis and related disorders
Date:3/3/2013

A study led by St. Jude Children's Research Hospital has discovered mutations in two genes that lead to the death of nerve cells in amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, and related degenerative diseases.

The same mutation occurred in both genes and led to the abnormal build-up of the proteins inside cells. These proteins play an essential role in normal RNA functioning and have also been linked to cancer, including the Ewing sarcoma, the second most common type of bone cancer in children and adolescents. The finding is the latest in a series of discoveries suggesting degenerative diseases and cancer may have common origins. RNA is the molecule that directs protein assembly based on instructions carried in DNA.

The study also adds to evidence that seemingly unrelated neurodegenerative diseases may involve similar defects in RNA metabolism. Researchers linked the problems to a specific region of the mutated proteins whose normal function was unclear. The study was published today in the advanced online edition of the scientific journal Nature.

"I hope this study helps to build the foundation for desperately needed treatments for ALS and perhaps a broad range of diseases caused by abnormal RNA metabolism," said J. Paul Taylor, M.D., Ph.D., an associate member of the St. Jude Department of Developmental Neurobiology and senior author of the study. Taylor and James Shorter, Ph.D., an assistant professor in the biochemistry and biophysics department at the University of Pennsylvania's Perelman School of Medicine, are the study's corresponding authors.

Each year approximately 5,600 people in the U.S. are found to have ALS. The disease is nearly always fatal, often within five years. Patients suffer muscle wasting and paralysis that affects their limbs and trunk as well as their ability to talk, swallow and breathe. There is no cure.

For this project, St. Jude sequenced just the p
'/>"/>

Contact: Summer Freeman
summer.freeman@stjude.org
901-595-3061
St. Jude Children's Research Hospital
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scientists find surprising new influence on cancer genes
2. MBL scientists find genes linked to human neurological disorders in sea lamprey genome
3. Schizophrenia genes increase chance of IQ loss
4. A microbial biorefinery provides new insight into how bacteria regulate genes
5. New genes for short-sightedness identified
6. Evaluating evolutionary rates could shed light into functions of uncharacterized genes
7. 1 of the key circuits in regulating genes involved in producing blood stem cells is deciphered
8. Evidence mounts for role of mutated genes in development of schizophrenia
9. First in the world - Singapore scientists discover genes responsible for cornea blindness
10. A history lesson from genes
11. International study suggests human genes influence gut microbial composition
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... 22, 2015 Research and Markets ( ... "Global Wearable Technologies Market and Applications, Opportunities, ... and Forecast 2014-2020" report to their offering. ... devices that can be worn on the user,s ...
(Date:12/22/2014)... Research and Markets ( http://www.researchandmarkets.com/research/fx4bg3/the_global ) ... Global Watermarking and Fingerprinting Markets" report to ... This insight provides an overview ... markets. Watermarking aims to control and monitor piracy ...
(Date:12/19/2014)... LAS VEGAS , Dec. 18, 2014   LaunchKey ... built for the post-password and Internet of Things era, ... seed funding. The venture round was led by Metamorphic ... Capital, Rimrock Venture Partners, VegasTechFund, and others.  LaunchKey has ...
Breaking Biology News(10 mins):Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 2The Global Watermarking and Fingerprinting Markets 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3
... from also becoming infected with hepatitis, researchers argue in a ... put people at higher risk of contracting HIV sharing ... also raise their risk of getting hepatitis B or ... be deadly. The study, which included all registered cases ...
... diseases like Alzheimer,s and Parkinson,s endogenous proteins accumulate in ... cells. These deposits, which consist of abnormally formed proteins, ... brain, thereby contributing to the development of the illness. ... and the US shows that certain protein particles are ...
... the genetic material of those animal and plant ... at the Institute of Molecular Genetics, Genetic Security ... (JGU) have developed a novel screening procedure that ... plant, and microbial substances present in foodstuffs. For ...
Cached Biology News:HIV sufferers need hepatitis safeguards 2Transmission routes of spreading protein particles 2New DNA test identifies ingredients in foods 2
(Date:1/22/2015)... 22, 2015 Selexis SA, a serial ... Cell Banks (RCBs) used for drug discovery to commercial ... will include Next-Generation Sequencing (NGS) data packages. ... biologic manufacturing by ensuring the integrity of the gene, ...
(Date:1/22/2015)... GenoSpace , a precision medicine software company that has developed ... of genomic, imaging and other biomedical data in research and ... , CEO of Aspera, an IBM Company, to its board ... "We are pleased to welcome Michelle ...
(Date:12/24/2014)...  Vermillion, Inc. (Nasdaq:   VRML), a bio-analytical solutions ... the Company closed its previously announced private placement ... W. Schuler , Birchview Fund LLC and several ... offering expenses.  The proceeds will be used for ...
(Date:12/24/2014)... 2014 SoundConnect’s 2015 ... cutting edge communication technology, provide continued education and ... webinar series demonstrates online communication features and benefits; ... conferencing’s most innovative and powerful tools. , According ...
Breaking Biology Technology:Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2GenoSpace Expands Board with Appointment of Michelle Munson 2Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3
... the National Institute of Standards and Technology (NIST) have ... go through an intersection while keeping their cool. Ten ... fact. The demonstration, described in a forthcoming paper in ... scaling up trap technology to build a large-scale quantum ...
... April 8 The University of Maryland today announces ... Business Plan Competition.Finalists present their ideas to a panel of new ... the University of Maryland, College Park . The competition is ... Information Technology Category include: , , ...
... DNA sequencing technology company, announced a definitive agreement ... investment in the company. Prompting its decision was ... reversible terminator chemistry, Lightning Terminators (TM), for ... chemistry as reagent kits to the market as ...
Cached Biology Technology:X marks the spot: Ions coldly go through NIST trap junction 2University of Maryland Announces Finalists for $75K Business Plan Competition 2University of Maryland Announces Finalists for $75K Business Plan Competition 3University of Maryland Announces Finalists for $75K Business Plan Competition 4University of Maryland Announces Finalists for $75K Business Plan Competition 5University of Maryland Announces Finalists for $75K Business Plan Competition 6SeqWright to Invest in LaserGen's Novel Lightning Terminators(TM) 2
RAB32, member RAS oncogene family, mRNA (cDNA clone MGC:13500 IMAGE:4280407), complete cds...
Request Info...
Phospho-TAO2 (S181) Affinity Purified Polyclonal Ab Protein Family: Other Intracellular Kinases...
PEG 8000 is used in the precipitation of phage, isolation of plasmid DNA and the enhancement of blunt-ended ligation reactions....
Biology Products: