Navigation Links
2 new compounds show promise for eliminating breast cancer tumors
Date:11/19/2008

Two new compounds created by a University of Central Florida professor show early promise for destroying breast cancer tumors.

Associate Professor James Turkson's compounds disrupt the formation and spread of breast cancer tumors in tests on mice. The compounds, S3I-201 and S3I-M2001, break up a cancer-causing protein called STAT3, and researchers have observed no negative side effects so far.

"The compounds are very promising," Turkson said. "They've worked very well in mice, and now we're looking for partners to help us take these compounds to the next level of trials."

Turkson's research has been published in the academic journals Proceedings of the National Academy of Sciences and ACS Chemical Biology, and he has obtained patents for both compounds.

Turkson is passionate about his research and has a very personal reason for wanting to find a cure for cancer. During his first year of college, his 52-year-old mother was diagnosed with uterine cancer and died. He dedicated his life to finding a cure.

The two compounds developed in his lab hold promise in part because they efficiently disrupt the abnormally active STAT3 protein he said.

"We all have the STAT3 protein in our bodies, and under normal circumstances it causes no harm. But in breast cancer patients, the protein is abnormally active. It never shuts off."

When that happens, the protein goes into overdrive and is bent on supporting the proliferation of breast cancer cells. The protein even creates a network of blood vessels to feed the cancer cells, support their growth and eventually promote the spread of the cancer into the blood, bones and organs.

"Our compounds go after STAT3, stripping away its power," Turkson said.

Both compounds disrupt the bonding process that one STAT3 molecule goes through to connect with another in the body. If the STAT3 can't bond to stay abnormally-active, cancer cells can't develop.
'/>"/>

Contact: Zenaida Gonzalez Kotala
zkotala@mail.ucf.edu
407-823-6120
University of Central Florida
Source:Eurekalert  

Page: 1 2

Related biology news :

1. New microsensor measures volatile organic compounds in water and air on-site
2. Naturally-occurring apple compounds reduce risk of pancreatic cancer
3. UDs Bobev receives NSF Early Career Award for research on novel compounds of rare Earth metals
4. Green tea compounds beat OSA-related brain deficits
5. Natural compounds in cocoa tied to blood flow improvements for adults with type 2 diabetes
6. New study shows compounds from soy affect brain and reproductive development
7. Duke team finds compounds that prevent nerve damage
8. Discovery of natural compounds that could slow blood vessel growth
9. New $11 million center to speed production of new compounds for drug discovery
10. 3-substituted indolones as novel therapeutic compounds for neurodegenerative conditions
11. Scripps research scientists identify compounds for stem-cell production from adult cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
2 new compounds show promise for eliminating breast cancer tumors
(Date:12/22/2014)... , Dec. 22, 2014  NXT-ID, Inc. (NASDAQ: ... authentication company focused on the growing mobile commerce market, announces ... Apollo Robbins for the 2015 International CES debut of ... Robbins will be at the NXT-ID booth January 6th ...
(Date:12/22/2014)... 2014  The 2014 Holiday Season may be the brightest ... reports that the long anticipated floodgates for consumer biometrics ... for smart phones, tablets, and wearable mobile devices that ... billion users with nearly 4.8 billion biometric devices by ...
(Date:12/19/2014)... 2014 Research and Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ) has ... America Perimeter Security Systems Market" report to their offering. ... North American perimeter security market is estimated to grow at ... U.S. market holds a larger share in this market, ...
Breaking Biology News(10 mins):NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 4First Season of Holiday Shopping with Mobile Biometric Payments Wraps Up With a Present for Biometrics Industry: A Rosy Forecast for More Than 2 Billion Users of 4.8 Billion Mobile Biometric Devices by 2020 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3
... the least understood of all liquids despite a century of ... and even the entire human body could be cyropreserved without ... researcher Anatoli Bogdan, Ph.D. , He conducted the study, scheduled ... of Physical Chemistry B , one of 34 peer-review journals ...
... and Health Sciences Center and Stanford University have discovered ... DNA damage and other acute stresses, and if disrupted ... new diagnostic markers and cancer treatments with fewer side ... 21 advanced online version of the journal Nature. , ...
... corn on the cob, farmers usually leave the stalks and ... State researchers think corn stover can be used not only ... are looking at using cellulose to make ethanol," says Dr. ... can make ethanol from exploded corn stover, but once you ...
Cached Biology News:Slow-frozen people? Latest research supports possibility of cyropreservation 2Researchers uncover new mechanism of tumor suppressor 2Corn waste potentially more than ethanol 2
(Date:1/22/2015)... Diagenode, Inc., a leading global provider ... complete solutions for epigenetics research, recently launched a ... need for manual processing. The new ChIPettor System ... histones or transcription factors and a semi-automated pipette ...
(Date:1/22/2015)... Medical Systems (NYSE: VAR ), world leader in ... to sustainability with inclusion on a prestigious list of the ... equipment company among the Corporate Knights Global 100 Most Sustainable ... Davos, Switzerland . "We ...
(Date:12/25/2014)... 2014 The report “Service Quality Management ... & Provider Type - Global Advancements, Worldwide Forecasts & ... in-depth analysis and forecasting of revenues. , Browse ... pages and in-depth TOC on “Service Quality Management (SQM) ...
(Date:12/24/2014)... Dec. 24, 2014  Vermillion, Inc. (Nasdaq:   VRML), ... announced today that the Company closed its previously ... Management, Jack W. Schuler , Birchview Fund ... $10.5 million, before offering expenses.  The proceeds will ...
Breaking Biology Technology:Diagenode Launches Unique Semi-Automated Solution for Chromatin Immunoprecipitation 2Varian Honored Among World's 100 Most Sustainable Corporations 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3
... , , PRINCETON, N.J., Aug. 5 ... the Canaccord Adams 29(th) Annual Global Growth Conference in Boston, MA. , ... will provide an overview of the company on Wednesday, August 12, 2009 ... simultaneous webcast of Mr. Price,s overview via the internet, log on to ...
... , , , ATLANTA, Aug. ... an Atlanta-based HIV/AIDS vaccine development company, today announced updates on its ... "We have two main areas of focus for our ... Executive Officer and President of GeoVax Labs, Inc. "The results ...
... , , NEWARK, N.J., Aug. ... a specialty chemical technology based Life Science Company announced today ... an impartial blind testing protocol Ygiene(TM) Hospital Grade Antimicrobial was ... , Many of today,s commercially available antimicrobials and ...
Cached Biology Technology:Pharmasset to Present at Canaccord Adams Conference 2Pharmasset to Present at Canaccord Adams Conference 3GeoVax Labs, Inc. Provides Clinical Studies Update 2GeoVax Labs, Inc. Provides Clinical Studies Update 3GeoVax Labs, Inc. Provides Clinical Studies Update 4GeoVax Labs, Inc. Provides Clinical Studies Update 5BioNeutral's Ygiene(TM) Hospital Grade Antimicrobial Proven To Be Completely Inert to Steel In Independent Corrosion Testing 2BioNeutral's Ygiene(TM) Hospital Grade Antimicrobial Proven To Be Completely Inert to Steel In Independent Corrosion Testing 3
... EA. Ultrospec 6300 pro UV/Visible ... the Pharmacopoeia in terms of instrument specification ... being able to be used for rapid, ... excellent scanning capability., *Press to read high ...
Recombinant Human CCL21/6Ckine (Mucin Stalk Chimera)...
...
... MBP Coated Microplate, 96 Well ... 5X, #20 Magnesium/ATP Cocktail, #20-11 Blocking ... LumiGLO™ Chemiluminescen LumiGLO™ Chemiluminescen ... Quality Assurance: Routinely evalauted ...
Biology Products: