Navigation Links
2 new compounds show promise for eliminating breast cancer tumors

Two new compounds created by a University of Central Florida professor show early promise for destroying breast cancer tumors.

Associate Professor James Turkson's compounds disrupt the formation and spread of breast cancer tumors in tests on mice. The compounds, S3I-201 and S3I-M2001, break up a cancer-causing protein called STAT3, and researchers have observed no negative side effects so far.

"The compounds are very promising," Turkson said. "They've worked very well in mice, and now we're looking for partners to help us take these compounds to the next level of trials."

Turkson's research has been published in the academic journals Proceedings of the National Academy of Sciences and ACS Chemical Biology, and he has obtained patents for both compounds.

Turkson is passionate about his research and has a very personal reason for wanting to find a cure for cancer. During his first year of college, his 52-year-old mother was diagnosed with uterine cancer and died. He dedicated his life to finding a cure.

The two compounds developed in his lab hold promise in part because they efficiently disrupt the abnormally active STAT3 protein he said.

"We all have the STAT3 protein in our bodies, and under normal circumstances it causes no harm. But in breast cancer patients, the protein is abnormally active. It never shuts off."

When that happens, the protein goes into overdrive and is bent on supporting the proliferation of breast cancer cells. The protein even creates a network of blood vessels to feed the cancer cells, support their growth and eventually promote the spread of the cancer into the blood, bones and organs.

"Our compounds go after STAT3, stripping away its power," Turkson said.

Both compounds disrupt the bonding process that one STAT3 molecule goes through to connect with another in the body. If the STAT3 can't bond to stay abnormally-active, cancer cells can't develop.

Contact: Zenaida Gonzalez Kotala
University of Central Florida

Page: 1 2

Related biology news :

1. New microsensor measures volatile organic compounds in water and air on-site
2. Naturally-occurring apple compounds reduce risk of pancreatic cancer
3. UDs Bobev receives NSF Early Career Award for research on novel compounds of rare Earth metals
4. Green tea compounds beat OSA-related brain deficits
5. Natural compounds in cocoa tied to blood flow improvements for adults with type 2 diabetes
6. New study shows compounds from soy affect brain and reproductive development
7. Duke team finds compounds that prevent nerve damage
8. Discovery of natural compounds that could slow blood vessel growth
9. New $11 million center to speed production of new compounds for drug discovery
10. 3-substituted indolones as novel therapeutic compounds for neurodegenerative conditions
11. Scripps research scientists identify compounds for stem-cell production from adult cells
Post Your Comments:
Related Image:
2 new compounds show promise for eliminating breast cancer tumors
(Date:9/30/2015)... , Sept. 30, 2015  The global glucose monitoring ... for 2015. So says a new report on the industry ... management segment dominate the market, followed by continuous glucose monitoring ... reports on the market for these products in its latest ... ...
(Date:9/28/2015)... 2015  The monitoring of vital signs, such ... is an essential component of patient assessment. Changes ... in a patient,s condition. However, in general care ... taken during routine observation rounds only once every ... between these observation rounds, the warning signs can ...
(Date:9/26/2015)... 2015  Results of a TactioRPM pilot project ... at the Stanford Medicine X Conference. In a ... Connected Health Devices and Pharmacogenomics", Roger Simard ... explain how senior patients equipped with connected health ... via the TactioRPM remote patient monitoring platform were ...
Breaking Biology News(10 mins):
... in traffic may cause a headache, but a delay ... of Missouri researchers have uncovered clues identifying which proteins ... and found that the proteins previously thought to play ... the nervous system develops will give researchers a better ...
... A team of Vanderbilt University Medical Center investigators has ... a new class of drugs for treating cancer., The ... phospholipase D (PLD), an enzyme that has been implicated ... colorectal., The new inhibitors, reported in the February issue ...
... gardening can offer enough moderate physical activity to keep older ... February in the journal HortScience , the researchers discovered ... older hands strong and nimble. "One of the things ... better hand strength and pinch force, which is a big ...
Cached Biology News:
(Date:10/8/2015)... Life Sciences Inc. (OTCQB: REPCF) (TSX.V: RP), a clinical ... autologous cell therapies, today announced its schedule of upcoming presentations ... month of October: Stem Cell Meeting on ... presenting at the annual Partnering Forum, part of the ... October 7-9 in La Jolla, California ...
(Date:10/8/2015)... ... 2015 , ... Cystic fibrosis (CF) is a genetic disease ... results in dysfunction of the lungs and the gastrointestinal (GI) tract. In CF ... very difficult to clear, blocks the airways and the glands, and creates an ...
(Date:10/7/2015)... Calif. , Oct. 7, 2015  ChromaDex ... wellness and nutritional ingredients that creates science-based solutions ... sports nutrition, and pharmaceutical products, today announced that ... , CEO and Founder, is now available for ...   -->   ...
(Date:10/7/2015)... , Oct. 7, 2015   Intrexon Corporation ... today announced it will hold an Investor Day in ... afternoon of Thursday, November 12, 2015. Intrexon,s Chairman and ... other members of the Company,s management team as well ... focus on strategic initiatives, product pipeline, and program updates ...
Breaking Biology Technology:
... drive to make healthcare information technology interoperable across ... and a medical information technology company headquartered here ... is lending its expertise to developing an ... the healthcare industry. Specifically, the expertise of Damien ...
... Sonic Foundry, Inc. has announced that it ... the fourth quarter of 2006, its first cash-positive quarter ... been building toward profitability since moving into the rich-media ... which the company showcased new search technology. , ,The ...
... . - Following weeks of blistering criticism of its electronic ... Foundation Health Plan , Madison's Epic Systems Corp . ... defending its product. , ,Epic Systems, a medical software developer, ... its electronic records system, which Kaiser has re-branded with the ...
Cached Biology Technology:
Anti-NCAPD3 Monoclonal AntibodyOther Sub-Family: not assigned-Other Applications: Immunoprecipitation, Western Blot...
... Lyophilized solid. Supplied as a ... UNDER INERT GAS. A cell-permeable mutated analog ... 196810) that serves as a negative control. ... Purity: ≥97% by HPLC. Soluble ...
BD Falcon microtest assay plate. 1536 well 12l, black, flat-bottom PS. Polystyrene, nonsterile, no lid. (15/sp, 60/ca) Packaging: 15 / pack, 60 / case ...
... flexible, fully automated microplate strip washer for 96- ... automated microplate strip washing capability, the Columbus combines ... operation. , Features ... 8, 12 or 16 channels, crosswise aspiration, overflow ...
Biology Products: