Navigation Links
2 new compounds show promise for eliminating breast cancer tumors
Date:11/19/2008

Two new compounds created by a University of Central Florida professor show early promise for destroying breast cancer tumors.

Associate Professor James Turkson's compounds disrupt the formation and spread of breast cancer tumors in tests on mice. The compounds, S3I-201 and S3I-M2001, break up a cancer-causing protein called STAT3, and researchers have observed no negative side effects so far.

"The compounds are very promising," Turkson said. "They've worked very well in mice, and now we're looking for partners to help us take these compounds to the next level of trials."

Turkson's research has been published in the academic journals Proceedings of the National Academy of Sciences and ACS Chemical Biology, and he has obtained patents for both compounds.

Turkson is passionate about his research and has a very personal reason for wanting to find a cure for cancer. During his first year of college, his 52-year-old mother was diagnosed with uterine cancer and died. He dedicated his life to finding a cure.

The two compounds developed in his lab hold promise in part because they efficiently disrupt the abnormally active STAT3 protein he said.

"We all have the STAT3 protein in our bodies, and under normal circumstances it causes no harm. But in breast cancer patients, the protein is abnormally active. It never shuts off."

When that happens, the protein goes into overdrive and is bent on supporting the proliferation of breast cancer cells. The protein even creates a network of blood vessels to feed the cancer cells, support their growth and eventually promote the spread of the cancer into the blood, bones and organs.

"Our compounds go after STAT3, stripping away its power," Turkson said.

Both compounds disrupt the bonding process that one STAT3 molecule goes through to connect with another in the body. If the STAT3 can't bond to stay abnormally-active, cancer cells can't develop. The network of blood vessels that formed to feed the cancer cells also shuts off.

Left without their source of food, the existing cancer cells die off. The body's immune system, which until now has been tricked by the abnormally active STAT3 into thinking the tumor cells are harmless, also recognizes that something is wrong. The immune system re-activates, recognizes any remaining cancer cells as harmful and destroys them.

Turkson worked with researchers at the H. Lee Moffitt Cancer Center and Research Institute, and the Beckman Research Institute and the Comprehensive Cancer Center of the City of Hope National Medical Center.

Turkson is a native of Ghana, West Africa. He completed his studies and obtained his honors B.S. degree in Biochemistry with Chemistry at the University of Ghana. He earned a Ph.D. in Pharmacology from the University of Alberta in Canada.

He completed post-doctoral fellow training in Molecular Oncology at the H. Lee Moffitt Cancer Center and Research Institute in Tampa, where he served as an assistant professor before joining UCF's Burnett School of Biomedical Sciences in 2005.

While Turkson continues to look for partners to further his research, he's already working on a similar compound for pancreatic cancer.

In that case the compound would enhance the potency of another drug and use the body's immune system to make the effect more powerful.


'/>"/>

Contact: Zenaida Gonzalez Kotala
zkotala@mail.ucf.edu
407-823-6120
University of Central Florida
Source:Eurekalert  

Related biology news :

1. New microsensor measures volatile organic compounds in water and air on-site
2. Naturally-occurring apple compounds reduce risk of pancreatic cancer
3. UDs Bobev receives NSF Early Career Award for research on novel compounds of rare Earth metals
4. Green tea compounds beat OSA-related brain deficits
5. Natural compounds in cocoa tied to blood flow improvements for adults with type 2 diabetes
6. New study shows compounds from soy affect brain and reproductive development
7. Duke team finds compounds that prevent nerve damage
8. Discovery of natural compounds that could slow blood vessel growth
9. New $11 million center to speed production of new compounds for drug discovery
10. 3-substituted indolones as novel therapeutic compounds for neurodegenerative conditions
11. Scripps research scientists identify compounds for stem-cell production from adult cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
2 new compounds show promise for eliminating breast cancer tumors
(Date:12/7/2016)... According to a new market research report "Emotion Detection and Recognition Market ... Application Area, End User, And Region - Global Forecast to 2021", published by ... 2016 to USD 36.07 Billion by 2021, at a Compound Annual Growth Rate ... ... MarketsandMarkets Logo ...
(Date:12/6/2016)... -- Valencell , the leading innovator in performance ... third consecutive year of triple digit growth for its ... a 360 percent increase in companies who have acquired ... by sales of its wrist and ear Benchmark™ sensor ... for hearables for fitness and healthcare applications. ...
(Date:11/30/2016)... 30, 2016 Not many of us realize that we spend ? of ... we need to do it well. Inadequate sleep levels have been found to lead ... diabetes, and even cancer. Maybe now is the best time to rethink ... them to manage their sleep quality? Continue Reading ... ...
Breaking Biology News(10 mins):
(Date:12/8/2016)... Dec. 8, 2016  OncoSec Medical Incorporated ("OncoSec") ... DNA-based intratumoral cancer immunotherapies, today announced financial results ... "We are delivering on our commitment to ... ImmunoPulse® IL-12. We are pleased with the early ... trial, and we are focused on advancing our ...
(Date:12/8/2016)... , Dec. 8, 2016  Renova™ Therapeutics, ... congestive heart failure and type 2 diabetes, announced ... a novel adeno-associated virus (AAV) vector developed in ... M.D., Ph.D., at Stanford University. The company plans ... paracrine gene therapy product pipeline. ...
(Date:12/8/2016)... December 8, 2016 ... Molekulargenetik, erweitert seine Palette an anpassbaren SureSeq™ NGS-Panels ... FH Panels, das ein schnelles und kostengünstiges Studium ... Panel bietet eine Erkennung von Einzel-Nukleotid-Variationen (Single Nucleotide ... einem einzigen kleinen Panel und ermöglicht eine individuelle ...
(Date:12/8/2016)... (PRWEB) , ... December 08, ... ... announces the commercial launch of flexible packaging for their exceptionally efficient human ... bag system extends RoosterBio’s portfolio of bioprocess media products engineered to radically ...
Breaking Biology Technology: