Navigation Links
2 in 1: Multi-tasking protein provides new approaches for anti-tuberculosis drugs
Date:2/15/2011

In a paper published today in PNAS, scientists from the European Molecular Biology Laboratory (EMBL) in Hamburg, Germany, reveal new insights into the workings of enzymes from a group of bacteria including Mycobacterium tuberculosis, the bacterium that causes tuberculosis. The new findings present possible new opportunities for developing organism-specific drugs, which target the pathogen but leave other microorganisms, which are beneficial to us, untouched.

Tuberculosis remains one of the largest threats to human health worldwide, and one of the most frequent causes of death in HIV patients. With the increasing emergence of strains of Mycobacterium tuberculosis that are hyper-resistant to drugs, it becomes ever more urgent that novel treatments be developed, and the search for novel strategies for drug development is an important step in this process.

In the current study, Matthias Wilmanns and his group at EMBL identified a multi-tasking enzyme from Mycobacterium tuberculosis that catalyses reactions on two different molecules, or substrates. In most organisms, cells need two specific enzymes, known as HisA and TrpF, in order to produce two essential amino acids histidine and tryptophan. However, in Mycobacterium tuberculosis, the encoding gene for TrpF is missing, and the two reactions are instead catalysed by a single enzyme, which is able to recognize and bind to two different substrates. This enzyme is known as PriA.

Using the Mycobacterium tuberculosis version of the PriA enzyme as a model, the researchers were able to unravel the hitherto unknown mechanism of bi-substrate specific binding observed in this group of bacteria.

"When we solved the three-dimensional structure of PriA, we found that it has the unique ability to form two different substrate-specific active sites," Wilmanns says: "it can form a reaction-specific active site, or undergo what we call 'substrate-induced me
'/>"/>

Contact: Sonia Furtado
sonia.furtado@embl.de
European Molecular Biology Laboratory
Source:Eurekalert

Page: 1 2

Related biology news :

1. Blood-clotting protein linked to cancer and septicemia
2. A protein reinforces memory and prevents forgetfulness
3. Pitt team grows arteries with most elastic protein reported, big step for living vascular grafts
4. Scientists link protein to the insulation of the nervous systems wiring
5. New method for rapidly producing protein-polymers
6. New study shows soy protein lowers non-HDL cholesterol significantly more than milk protein
7. New method takes snapshots of proteins as they fold
8. Mayo researchers describe measles viral protein movement
9. Princeton scientists construct synthetic proteins that sustain life
10. Scripps Research chemist devises new method to quantify protein changes
11. Eating low-fat, thanks to lupin proteins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/9/2015)... 9, 2015 Synaptics Inc. (NASDAQ: SYNA ), ... that it will report financial results for the third ... after the close of market. The company will host ... 2:00 p.m. PT (5:00 p.m. ET), during which management ... on the live call, analysts and investors should dial ...
(Date:4/6/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... on the growing mobile commerce market, announced today ... MINIATURE, MULTI-PURPOSE ANTENNA METHOD AND SYSTEM FOR ... introduces a new revolutionary method and system to ... of miniature antenna modules for multiple purposes including ...
(Date:4/2/2015)... 2, 2015 At its 2015 ACMG Annual ... , the American College of Medical Genetics and ... to its Board.  Members of the ACMG Board of ... forming and advancing its policies and programs. ACMG is ... "It,s an eventful time in medical genetics and ...
Breaking Biology News(10 mins):Synaptics to Report Third Quarter Results on April 23 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 5American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 6American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 7American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 8
... Sounding the chest with a cold stethoscope is probably ... medical room after peering down the back of the ... in the inaugural issue of the International Journal ... add an information-age approach to diagnosing heart problems. The ...
... A new NOAA coral bleaching prediction system indicates that ... this year, but the event will probably not be ... this week at the 11th International Coral Reef Symposium ... that there is a risk of widespread bleaching in ...
... The National Institutes of Health (NIH) has awarded a ... of Biology Lara D. Hutson, in support of her ... the most common inherited neuromuscular disease, affecting as many ... dominant inheritance and symptoms generally appear during adolescence or ...
Cached Biology News:Sounding out heart problems automatically 2New NOAA coral bleaching prediction system calls for low level of bleaching in Caribbean this year 2
(Date:5/21/2015)... May 21, 2015 Patent Offering, The ... for diagnostic or therapeutic imaging within a body lumen ... an endoscope having a low cost, single-use disposable illumination ... date was October 18, 2013 and the patent approval ... enables the physician to customize the lighting and magnification ...
(Date:5/21/2015)... , May 20, 2015 Research and ... the addition of the "2015 Global Survey ... their offering. The primary goal of ... flow cytometry instruments and reagents. Key information the ... the selection of flow cytometers, predominantly used applications ...
(Date:5/21/2015)... (PRWEB) May 21, 2015 Tunnell ... joined the firm as senior statistician and Principal, a ... of experience in the management and analysis of complex ... and chemical industries. , “We’re delighted to have Julia ... in data analytics,” said Dr. Philippe Cini, Group Vice ...
(Date:5/20/2015)... (PRWEB) May 20, 2015 This year ... especially for lawns. US Patented Pearl’s Premium Ultra ... lawns around the country that are coming out of ... addresses a number of major global concerns related to ... “non-grass” grass – the alternative to the standard, water-wasting, ...
Breaking Biology Technology:IpAuctions™ Presents The Worlds Smallest Disposable Illuminated Endoscope For Auction 2IpAuctions™ Presents The Worlds Smallest Disposable Illuminated Endoscope For Auction 3Global Survey on Flow Cytometry Adoption Trends 2015 2Julia O’Neill Joins Tunnell Consulting’s Operational and Process Improvement Practice 2Breakthrough 4th Generation Low Maintenance Lawn Seed Offers Solution to California Drought 2
... Cadence Pharmaceuticals,Inc. (Nasdaq: CADX ) a biopharmaceutical ... candidates principally,for use in the hospital setting, announced ... to purchase up to 9,240,307 shares of,Cadence,s common ... share pursuant to,an effective shelf registration statement., ...
... of Medicine of Yeshiva University have shown for the ... (the most common form of the disease) in an ... the Journal of Clinical Investigation. , Hemophilia A affects ... spontaneous bleeding that can cause disability or death. It ...
... helped lead a collaborative effort to uncover a ... (Staph) infections. The research, published Feb. 14 in ... at a time when strains of antibiotic-resistant Staph ... spreading in epidemic proportions in hospital and community ...
Cached Biology Technology:Cadence Pharmaceuticals to Raise up to $49.3 Million in Registered Direct Common Stock Offering 2Transplanted cells may hold the key to curing hemophilia A, Einstein scientists report 2New approach may render disease-causing staph harmless 2New approach may render disease-causing staph harmless 3
Rabbit polyclonal to M13 Bacteriophage Coat Proteins ( Abpromise for all tested applications)....
Pancreatic Cell Cryopreservation Medium (2X) is intended for the cryopreservation of LT2 Immortalized Pancreatic Mesenchymal Cells (SCR013) and VIT1 Primary Pancreatic Mesenchymal Cells (SCR014)....
Naphthol Blue Black, CI 20470...
Recognizes rat Taste Receptor 2 (TR2). The immunogen shows no significant sequence homology with TR1, gustducin or other pheromone receptors....
Biology Products: