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2 carotid artery stenting studies show results comparable to AHA guidelines
Date:10/23/2007

mination of such patients, and although the guidelines were established for surgery (before stenting was practiced), there are no comparable surgical results in this group of patients.

In 1998, the American Heart Association published its 30 day outcome guidelines in Circulation for patients treated with carotid artery surgery. These guidelines were based on the observed stroke and death rates in patients with carotid artery disease who had undergone surgery, called carotid endarterectomy, to treat their condition. The guidelines were based on studies of surgery in patients who did not have excessive risks for anesthesia, etc., but left unanswered what the best therapy is for patients for whom surgery was risky. These two studies are the first demonstration of a therapy providing stroke prevention (carotid artery stenting) in these patients and they provide an option to those facing difficult decisions regarding the risks of surgery.

The CAPTURE 2 study included 1,987 patients and utilized Abbott's ACCULINK(tm) Carotid Stent System and ACCUNET(tm) Embolic Protection System. The EXACT study included 2,124 patients and utilized Abbott's Xact(r) Rapid Exchange Carotid Stent System and Emboshield BareWire(tm) Rapid Exchange Embolic Protection System. The key objective of both trials was to determine whether carotid stenting could be performed safely in the real-world clinical setting by physicians with varying levels of experience. The primary endpoints were death, stroke and MI at 30 days. The demographics of patients in both trials were similar.

The 30-day composite endpoints of stroke and death for patients in the CAPTURE 2 and EXACT studies were:

  • 3.1 percent and 3.0 percent combined stroke and death in CAPTURE 2 and EXACT patients without symptoms under age 80
  • 6.0 percent and 7.3 percent combined stroke and death in CAPTURE 2 and EXACT patients with symptoms under age 80

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Contact: Alex Lyda
mal2133@columbia.edu
917-755-0354
Columbia University Medical Center
Source:Eurekalert

Page: 1 2 3

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