Navigation Links
2 beta blockers found to also protect heart tissue
Date:9/15/2008

DURHAM, N.C. A newly discovered chemical pathway that helps protect heart tissue can be stimulated by two of 20 common beta-blockers, drugs that are prescribed to millions of patients who have experienced heart failure.

Researchers from Duke University Medical Center tested 20 beta blockers and found that two of them -- alprenolol and carvedilol -- could stimulate a pathway recently found to protect heart tissue.

This finding could guide future drug development and in particular help heart failure patients, says Howard Rockman, M.D., senior author of the study and chief of the Duke Cardiology Division.

"To our surprise, we found that these two beta blockers can actually stimulate the beta receptor to activate a pathway in the cell that promotes cell survival. We have the first evidence that these two drugs have greater potential to repair the heart and to protect it, and possibly even to reverse some heart damage," Dr. Rockman said.

Until now, scientists believed that all beta-blockers worked by binding to and blocking the beta-adrenergic receptor, a molecule on the cell surface that responds to the hormone adrenalin. Blocking the receptor moderates increases in heart rate and heart function that could be damaging to patients whose hearts are already overstressed.

The two beta-blockers identified by the current study also serve to stimulate a different signaling beta-arrestin pathway. Beta arrestin is a protein known as an "off-switch" for beta-adrenergic receptors. These two drugs activated a beta-arrestin pathway that produces beneficial effects in the heart tissue.

"These two drugs were found to stimulate the pathway that produces certain proteins that are protective to the heart," Rockman said.

The new study, published online in Proceedings of the National Academy of Sciences, was funded by that National Institutes of Health.

"Based on these findings, we hope to design drugs that strongly bind in this way and activate this pathway," Rockman said. "We call these drugs biased-ligands or super receptor blockers, because they are designed to block the harmful actions of adrenalin at the beta receptor, but at a molecular level will activate other pathways that protect the cell." Rockman and colleagues discovered the heart-protection factors in a study published last year.

He noted that carvedilol (marketed for many years as Coreg and now as available in generic forms) is known as a very effective beta blocker, but alprenolol has not been fully developed as a beta blocker drug for heart failure patients. Beta blockers now are part of a standard of care for heart failure patients, who have weakened hearts and cannot tolerate much adrenalin, which is released all day long in people as they perform any exertion, even reading an exciting novel. Every year, 400,000 new cases of heart failure are diagnosed and the number is growing as the population ages.

"The next step is to test the drugs in animals to learn which might promote protection and which might cause more negative effects," Rockman said. "Cell studies can be tricky to replicate in organisms and we will have to see what happens, but these cellular results are very exciting and encouraging and could be a boon to heart failure patients."


'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

Related biology news :

1. UT Knoxville wins 2 $3M National Science Foundation research and education grants
2. Substance found in fruits and vegetables reduces likelihood of the flu
3. New genes found for inflammatory bowel disease in children
4. New master switch found in the brain that regulates appetite and reproduction
5. The MDS Foundation supports the FDAs decision to expand vidaza label to include survival data
6. Genome of simplest animal reveals ancient lineage, confounding array of complex capabilities
7. Senescence in liver cells is found by CSHL scientists to help limit acute tissue damage
8. New York Stem Cell Foundation announces third annual Translational Stem Cell Research Conference
9. Toxoplasmosis found more severe in Brazil compared to Europe
10. Michael J. Fox Foundation PD Therapeutics Conference
11. Worlds smallest snake found in Barbados
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2017)... ARLINGTON, Va. , June 30, 2017 /PRNewswire-USNewswire/ ... a leading developer and supplier of face and ... the ATA Featured Product provider program. ... created an innovative way to monitor a driver,s ... benefit greatly from being able to detect fatigue ...
(Date:5/16/2017)... DALLAS , May 16, 2017   ... for health organizations, and MD EMR Systems ... certified development partner for GE, have established a ... Patient Portal product and the GE Centricity™ products, ... Centricity EMR. These new integrations ...
(Date:4/17/2017)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... 2016 Annual Report on Form 10-K on Thursday April 13, 2017 ... ... Investor Relations section of the Company,s website at http://www.nxt-id.com  under ... http://www.sec.gov . 2016 Year Highlights: ...
Breaking Biology News(10 mins):
(Date:7/18/2017)... ... 18, 2017 , ... Allotrope Foundation won the 2017 in ... the Allotrope Framework for commercial use. , The Bio-IT World Best Practices Awards ... the critical role of information technology in modern biomedical research, but also to ...
(Date:7/17/2017)... ... July 17, 2017 , ... ... instruments announced the launch of its new line of Heavy-Duty Orbital Shakers today. ... (both analog and digital) for laboratory applications. These shakers are ideal for ...
(Date:7/16/2017)... ... July 16, 2017 , ... OHAUS Corporation, a leading ... of its new line of Rocking and Waving Shakers today. , Five New ... analog and digital) for laboratory applications in a variety of environmental conditions. Rocking ...
(Date:7/14/2017)... ... July 13, 2017 , ... ... test kit has received US FDA 510 (k) clearance for use on Siemens ... evaluates D-Dimer. Each VALIDATE® D-Dimer kit, prepared using the CLSI EP06-A “equal delta” ...
Breaking Biology Technology: