Navigation Links
2 beta blockers found to also protect heart tissue
Date:9/15/2008

DURHAM, N.C. A newly discovered chemical pathway that helps protect heart tissue can be stimulated by two of 20 common beta-blockers, drugs that are prescribed to millions of patients who have experienced heart failure.

Researchers from Duke University Medical Center tested 20 beta blockers and found that two of them -- alprenolol and carvedilol -- could stimulate a pathway recently found to protect heart tissue.

This finding could guide future drug development and in particular help heart failure patients, says Howard Rockman, M.D., senior author of the study and chief of the Duke Cardiology Division.

"To our surprise, we found that these two beta blockers can actually stimulate the beta receptor to activate a pathway in the cell that promotes cell survival. We have the first evidence that these two drugs have greater potential to repair the heart and to protect it, and possibly even to reverse some heart damage," Dr. Rockman said.

Until now, scientists believed that all beta-blockers worked by binding to and blocking the beta-adrenergic receptor, a molecule on the cell surface that responds to the hormone adrenalin. Blocking the receptor moderates increases in heart rate and heart function that could be damaging to patients whose hearts are already overstressed.

The two beta-blockers identified by the current study also serve to stimulate a different signaling beta-arrestin pathway. Beta arrestin is a protein known as an "off-switch" for beta-adrenergic receptors. These two drugs activated a beta-arrestin pathway that produces beneficial effects in the heart tissue.

"These two drugs were found to stimulate the pathway that produces certain proteins that are protective to the heart," Rockman said.

The new study, published online in Proceedings of the National Academy of Sciences, was funded by that National Institutes of Health.

"Based on these findings, we hope to design d
'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

1

GOOD

Page: 1 2

Related biology news :

1. UT Knoxville wins 2 $3M National Science Foundation research and education grants
2. Substance found in fruits and vegetables reduces likelihood of the flu
3. New genes found for inflammatory bowel disease in children
4. New master switch found in the brain that regulates appetite and reproduction
5. The MDS Foundation supports the FDAs decision to expand vidaza label to include survival data
6. Genome of simplest animal reveals ancient lineage, confounding array of complex capabilities
7. Senescence in liver cells is found by CSHL scientists to help limit acute tissue damage
8. New York Stem Cell Foundation announces third annual Translational Stem Cell Research Conference
9. Toxoplasmosis found more severe in Brazil compared to Europe
10. Michael J. Fox Foundation PD Therapeutics Conference
11. Worlds smallest snake found in Barbados
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2013)... world,s largest scientific society, invites news media coverage ... 8-12, 2013, in Indianapolis, Ind. It will take ... area hotels. , With more than 7,100 presentations ... from astronomy to zoology ― the meeting will ... assortment of spot news and feature possibilities. The ...
(Date:5/21/2013)... way genes function without changing the underlying DNA ... of pregnant women during any trimester, potentially providing ... weeks after giving birth, and an opportunity to ... of the small study involving 52 pregnant women ... Psychiatry . , "Postpartum depression can be harmful ...
(Date:5/20/2013)... New research suggests that a compound abundant in ... escape death. , By altering a very specific ... cells into normal cells that die as scheduled. , ... a process that would cause them to die on ... This study in cells, led by Ohio State University ...
Breaking Biology News(10 mins):Genetic predictors of postpartum depression uncovered by Hopkins researchers 2Genetic predictors of postpartum depression uncovered by Hopkins researchers 3The compound in the Mediterranean diet that makes cancer cells 'mortal' 2The compound in the Mediterranean diet that makes cancer cells 'mortal' 3
... Scientists are to study a group of proteins that are ... key to developing new types of antibiotics. Researchers from ... from the Biotechnology and Biological Sciences Research Council (BBSRC) to ... force their way into bacterial cells before destroying them. ...
... London, 1 July, 2009 Johnson & Johnson ... Department of Molecular Biology at the Max Planck Institute ... novel cancer therapies including Herceptin (trastuzumab) , is the ... Biomedical Research. An independent committee of world-renowned scientists ...
... DNA strands damaged by oxidation leads to several types ... to the development of cancer. That,s the conclusion of ... researchers at the National Institute of Standards and Technology ... New York University School of Medicine (NYUSM). Although ...
Cached Biology News:Axel Ullrich named winner of 2009 Dr. Paul Janssen Award for Biomedical Research 2Genetically engineered mice yield clues to 'knocking out' cancer 2
(Date:5/21/2013)... Savoury Systems International (SSI), a leader in the ... USA Sales Broker. Braddy’s new role will allow SSI ... , In 2004 Braddy founded Southeastern Food ... processors and industrial manufacturers. Braddy has worked for ... has over 25 years of sales management experience. ...
(Date:5/21/2013)... Canada (PRWEB) May 21, 2013 ... is a strong push within the industry to ... and Manufacturing Organizations and pharma companies often means ... frames. , Microtablets, developed in collaboration with Sensidose ... effective outsourcing can bring products to market sooner. ...
(Date:5/21/2013)... Md. , May 21, 2013  Synthetic Biologics, Inc. ... prevention and treatment of serious infectious diseases, announced today that ... the 2 nd Annual Marcum LLP MicroCap Conference on ... at the Grand Hyatt Hotel. Mr. Riley is ... A live webcast of Synthetic Biologics, presentation can be accessed ...
(Date:5/21/2013)... (PRWEB) May 21, 2013 NANONEX ... nanoimprint solutions , today announced the successful delivery ... manufacturing system, the NX-M200B, to a major Japanese ... is a fully-automated, production-ready, advanced nanoimprint lithography tool ... of wafer and substrate sizes and types. Based ...
Breaking Biology Technology:The Development of an Innovative Microtablet Dosage Form, a Success Story: Live Webinar Hosted by Xtalks 2Synthetic Biologics to Present at the 2nd Annual Marcum LLP MicroCap Conference 2Nanonex Announces the Shipment and Installation of an Innovative Nanoimprint Lithography System for Fully Automated Manufacturing 2
... Cell Technology, Inc. ("ACT"; OTCBB: ACTC), a leader in the ... for the period ended March 31, 2011. The Company reported ... loss from operations of $(15.0) million in the 2010 first ... $(0.00) per share, compared to a loss in the same ...
... BALTIMORE and LIEGE, Belgium, May 9, 2011 BD ... (Becton, Dickinson and Company) (NYSE: BDX ), ... Belgium, announced today an agreement to co-develop seven initial ... pathogens associated with respiratory, enteric and central nervous system ...
... May 9, 2011 Auxilium Pharmaceuticals, Inc. (NASDAQ: ... and operational highlights for the quarter ended March 31, 2011. ... of $58.4 million compared to net revenues of $45.5 million ... the first quarter of 2011 was $(11.8) million, or $(0.25) ...
Cached Biology Technology:Advanced Cell Technology Announces 2011 First Quarter Results 2Advanced Cell Technology Announces 2011 First Quarter Results 3BD and Diagenode Collaborate to Expand Infectious Disease Menu on the BD MAX™ System 2BD and Diagenode Collaborate to Expand Infectious Disease Menu on the BD MAX™ System 3BD and Diagenode Collaborate to Expand Infectious Disease Menu on the BD MAX™ System 4Auxilium Pharmaceuticals, Inc. Announces First Quarter 2011 Financial Results and Operational Highlights 2Auxilium Pharmaceuticals, Inc. Announces First Quarter 2011 Financial Results and Operational Highlights 3Auxilium Pharmaceuticals, Inc. Announces First Quarter 2011 Financial Results and Operational Highlights 4Auxilium Pharmaceuticals, Inc. Announces First Quarter 2011 Financial Results and Operational Highlights 5Auxilium Pharmaceuticals, Inc. Announces First Quarter 2011 Financial Results and Operational Highlights 6Auxilium Pharmaceuticals, Inc. Announces First Quarter 2011 Financial Results and Operational Highlights 7Auxilium Pharmaceuticals, Inc. Announces First Quarter 2011 Financial Results and Operational Highlights 8
Rat Aortic Smooth Muscle Cells (RAOSMC) (>500,000 cells)...
... is an ideal small concentrator for the ... of removing water and organic solvents from ... microplates, vials and round bottom flasks. Making ... busy lab. ,The built-in special runs for ...
... a compact, versatile & modular instrument which can ... Intracellular, Extracellular, Transducer & Multi-channel Isolated Amplification ... & Power Supply unit (NL900D) forms the heart ... only powered by this unit, but wiring within ...
... Precision Model 410 is a four-channel general purpose ... small signals from sources which may have a ... channel consists of a high gain/low noise amplifier, ... and an output offset control. A control knob ...
Biology Products: