Navigation Links
2 at 1 stroke -- how cells protect themselves from cancer
Date:3/16/2010

Cells have two different protection programs to safeguard them from getting out of control under stress and from dividing without stopping and developing cancer. Until now, researchers assumed that these protective systems were prompted separately from each other. Now for the first time, using an animal model for lymphoma, cancer researchers of the Max Delbrck Center (MDC) Berlin-Buch and the Charit University Hospital Berlin in Germany have shown that these two protection programs work together through an interaction with normal immune cells to prevent tumors. The findings of Dr. Maurice Reimann and his colleagues in the research group led by Professor Clemens Schmitt may be of fundamental importance in the fight against cancer (Cancer Cell, Vol. 17, Issue 3, 16 March 2010, pp. 262-272; DOI 10.1016/j.ccr.2009.12.043)*.

Researchers have known for some time that paradoxically oncogenes themselves can activate these cell protection programs in an early developmental stage of the disease. This may explain why some tumors take decades to develop until the outbreak of the disease. The Myc oncogene triggers apoptosis (programmed cell death), inducing damaged cells to commit suicide in order to protect the organism as a whole. By means of chemotherapy, physicians activate this protection program to treat cancer.

The second protection program not as well understood as apoptosis is senescence (biological aging). This program is triggered by another oncogene, the ras gene. Senescence stops the cell cycle, and the cell can no longer divide. But in contrast to apoptosis the cell continues to live and is still metabolically active. Professor Schmitt, physician at Charit University Hospital and research group leader at the MDC, was able to show on an animal model for lymphoma that senescence can block the development of early-stage malignant tumors.

Myc oncogene triggers cascade to activate both protection programs

'/>"/>
Contact: Barbara Bachtler
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Preventing or reversing inflammation after heart attack, stroke may require 2-pronged approach
2. UAB study shows African-Americans have highest stroke rate, southerners more likely to die
3. Even small dietary reductions in salt could mean fewer heart attacks, strokes and deaths
4. New stroke therapy successful in rats
5. Study reveals how one form of natural vitamin E protects brain after stroke
6. Observation about how nervous system learns and encodes motion could improve stroke recovery
7. New understanding about mechanism for cell death after stroke leads to possible therapy
8. Top interventional radiologists, neurointerventionists explore stroke care through CLOTS
9. Beta-blockers and stroke -- new insights into their use for older people
10. Mouse brain rewires its neural circuits to recuperate from damaged neural function after stroke
11. Single gene defect can cause stroke, other artery diseases
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
2 at 1 stroke -- how cells protect themselves from cancer
(Date:2/10/2015)... 2015  Alere Inc. (NYSE: ALR), a global ... for the quarter ended December 31, 2014. ... of Alere said, "We made substantial progress in ... global leader in rapid diagnostics and delivering against ... divestiture in early January enabled us to substantially ...
(Date:2/5/2015)... Feb. 5, 2015  Marken is starting its 35 ... has launched a new marketing campaign to solidify its ... The new campaign focuses on First as ... shipments. The first headline in the series, ... priorities with its client,s priorities. Marken recognizes the need ...
(Date:2/5/2015)... , Jan. 27, 2015   ... of globally deployed, innovative test solutions for ... the delivery of its TS-323 GENASYS ... Systems Company (LMSSC). GENASYS is a high-performance ... of mission-critical applications that require performance functional ...
Breaking Biology News(10 mins):Alere Inc. Announces Fourth Quarter 2014 Results 2Alere Inc. Announces Fourth Quarter 2014 Results 3Alere Inc. Announces Fourth Quarter 2014 Results 4Alere Inc. Announces Fourth Quarter 2014 Results 5Alere Inc. Announces Fourth Quarter 2014 Results 6Alere Inc. Announces Fourth Quarter 2014 Results 7Alere Inc. Announces Fourth Quarter 2014 Results 8Alere Inc. Announces Fourth Quarter 2014 Results 9Alere Inc. Announces Fourth Quarter 2014 Results 10Alere Inc. Announces Fourth Quarter 2014 Results 11Alere Inc. Announces Fourth Quarter 2014 Results 12Alere Inc. Announces Fourth Quarter 2014 Results 13Alere Inc. Announces Fourth Quarter 2014 Results 14Alere Inc. Announces Fourth Quarter 2014 Results 15Alere Inc. Announces Fourth Quarter 2014 Results 16Alere Inc. Announces Fourth Quarter 2014 Results 17Alere Inc. Announces Fourth Quarter 2014 Results 18Alere Inc. Announces Fourth Quarter 2014 Results 19Alere Inc. Announces Fourth Quarter 2014 Results 20Alere Inc. Announces Fourth Quarter 2014 Results 21Alere Inc. Announces Fourth Quarter 2014 Results 22Alere Inc. Announces Fourth Quarter 2014 Results 23Alere Inc. Announces Fourth Quarter 2014 Results 24Alere Inc. Announces Fourth Quarter 2014 Results 25Alere Inc. Announces Fourth Quarter 2014 Results 26Alere Inc. Announces Fourth Quarter 2014 Results 27Alere Inc. Announces Fourth Quarter 2014 Results 28Alere Inc. Announces Fourth Quarter 2014 Results 29Alere Inc. Announces Fourth Quarter 2014 Results 30Alere Inc. Announces Fourth Quarter 2014 Results 31Alere Inc. Announces Fourth Quarter 2014 Results 32Alere Inc. Announces Fourth Quarter 2014 Results 33Alere Inc. Announces Fourth Quarter 2014 Results 34Alere Inc. Announces Fourth Quarter 2014 Results 35Alere Inc. Announces Fourth Quarter 2014 Results 36
... School of Medicine a three-year grant of more than $3 ... contribute to the development of autism. Stephen T. Warren, ... principal investigator of the program project that also includes Michael ... in human genetics. Autism occurs four to nine ...
... tiny grains resembling powder, which is extremely difficult to ... Synchrotron Radiation Facility (ESRF) and the Centre National de ... determine the structure of microcrystal grains of one cubic ... the size of the analysable samples, opening up new ...
... help reduce the risk of pancreatic cancer, says a ... naturally in apples and onions, has been identified as ... reducing the risk of pancreatic cancer. Although the ... who consumed foods rich in flavonols had a significantly ...
Cached Biology News:Simons Foundation awards Emory scientists $3M for autism gene research 2Unveiling the structure of microcrystals 2Naturally-occurring apple compounds reduce risk of pancreatic cancer 2
(Date:3/3/2015)... Ky. (PRWEB) March 03, 2015 Experts ... their schedules for one event: the Alltech REBELation exploring ... from May 17-20. Now in its 31st year, Alltech’s ... from 70 countries, and the opportunity to join the ... March 7 at 11:59 p.m. EST, at which point ...
(Date:3/3/2015)... 3, 2015 Adaptive Biotechnologies announced today that ... its Board of Director as Chair of the Audit ... Group, Chad oversees all finance, treasury and accounting functions. ... core finance, treasury and accounting functions, and led the ... In 2013, he was named Puget Sound Business Journal,s ...
(Date:3/3/2015)... The winners of awards for supply chain resilience ... Global Supply Chain Resiliency Council (GSCRC) at the ... 25th, 2015, at the Hyatt Regency in Santa Clara, ... supply chain risk management and resiliency practitioners with luminaries ... opportunities to collaborate, develop and share best practices, and ...
(Date:3/3/2015)... , March 3, 2015 AtheroNova Inc. (OTCQB: ... Operations, Inc., filed voluntary petitions under Chapter 11 of the ... of California , Santa Ana ... The Company,s Chapter 11 cases are expected to be jointly ... a Bankruptcy Court supervised asset sale process, for all or ...
Breaking Biology Technology:World-renowned Leaders, Authors and Businesspeople Join the Alltech REBELation 2World-renowned Leaders, Authors and Businesspeople Join the Alltech REBELation 3World-renowned Leaders, Authors and Businesspeople Join the Alltech REBELation 4Adaptive Biotechnologies adds Chad Cohen, Zillow Group CFO, to Board of Directors 2Global Supply Chain Resiliency Council Names Award Winners 2Global Supply Chain Resiliency Council Names Award Winners 3Global Supply Chain Resiliency Council Names Award Winners 4AtheroNova and its Subsidiary File for Chapter 11 Bankruptcy Protection 2AtheroNova and its Subsidiary File for Chapter 11 Bankruptcy Protection 3AtheroNova and its Subsidiary File for Chapter 11 Bankruptcy Protection 4
... PETLinQ(R) LLC is extremely proud to,announce the release ... RISLinQ(R) 4.0Mac provides full end to end workflow,capability for ... , Harsha Hatti, President and CEO of ... class, well respected and highly credible operating system that,many ...
... HUBEI PROVINCE, China, Nov. 18 ,Benda Pharmaceutical, Inc. (OTC ... a commercialized gene,therapy medicine for the treatment of cancer, ... for the three and,nine month periods ended September 30, ... with the SEC today. , ...
... its extensive experience in multi-GPU high-performance computing ... to provide scientists, engineers and researchers with ... Personal Supercomputer (PSC), which will be shown ... week,s SC08 Conference, the top international conference ...
Cached Biology Technology:PETLinQ Launches RISLinQ 4.0Mac on Mac OS X Platform 2Benda Pharmaceutical Reports Third Quarter 2008 Financial Results 2Benda Pharmaceutical Reports Third Quarter 2008 Financial Results 3Benda Pharmaceutical Reports Third Quarter 2008 Financial Results 4Benda Pharmaceutical Reports Third Quarter 2008 Financial Results 5Benda Pharmaceutical Reports Third Quarter 2008 Financial Results 6Benda Pharmaceutical Reports Third Quarter 2008 Financial Results 7Benda Pharmaceutical Reports Third Quarter 2008 Financial Results 8Benda Pharmaceutical Reports Third Quarter 2008 Financial Results 9BOXX Personal Supercomputer for Research Scientists Featured at SC08 2
Request Info...
Form: Concentrated Applications: ELISA...
Agarase cleaves agarose to neoagaro-oligosaccharides, and is used for,quantitative, gentle recovery of DNA from low melting point agarose....
Form: Ready to use Applications: ELISA...
Biology Products: