Navigation Links
1918 flu antibodies resurrected from elderly survivors
Date:8/17/2008

Ninety years after the sweeping destruction of the 1918 flu pandemic, researchers at Monroe Carell Jr. Children's Hospital at Vanderbilt have recovered antibodies to the virus from elderly survivors of the original outbreak.

In addition to revealing the surprisingly long-lasting immunity to such viruses, these antibodies could be effective treatments to have on hand if another virus similar to the 1918 flu breaks out in the future.

The study, led by James Crowe Jr., M.D., professor of Pediatrics and director of the Vanderbilt Program in Vaccine Sciences, Christopher Basler, Ph.D., at the Mount Sinai School of Medicine, and Eric Altschuler, M.D., Ph.D., at the University of Medicine and Dentistry of New Jersey-New Jersey Medical School, is published online in the journal Nature.

The influenza pandemic of 1918 killed nearly 50 million people worldwide, many of whom were young, healthy adults. With fears of another looming flu pandemic stoked by the emergence of "bird flu" in Asia, researchers have wanted to study the 1918 virus and the immune response to it.

In 2005, researchers from Mount Sinai and the Armed Forces Institute of Pathology in Washington, D.C., resurrected the 1918 virus from the bodies of people killed in the outbreak. The bodies, and the virus, had been preserved in the permanently frozen soil of Alaska.

When the investigators approached Crowe, whose lab had developed methods of making antibodies, to try to make antibodies to the 1918 flu, he was skeptical, but agreed to try.

The researchers collected blood samples from 32 survivors age 91-101 years and found that all reacted to the 1918 virus, suggesting that they still possessed antibodies to the virus.

Crowe's team was then able to isolate exceedingly rare B cells the immune cells that produce antibodies from eight of those samples and grow them in culture. Seven of those samples produced antibodies to a 1918 virus
'/>"/>

Contact: Craig Boerner
craig.boerner@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Presence of certain antibodies signals healthier teeth and gums
2. Synthetic molecules may be less expensive alternative to therapeutic antibodies, researchers find
3. Zinc may reduce pneumonia risk in nursing home elderly
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... chances are you are), help may be on the ... developed a vaccine that can combat dust-mite allergies by ... the nano-sized vaccine package lowered lung inflammation by 83 ... the paper, published in the AAPS (American ... reason why it works, the researchers contend, is because ...
(Date:7/22/2014)... research team from the National Institute of Standards ... has demonstrated a dramatically improved technique for analyzing ... vibration "signatures." The new NIST technique is an ... spectroscopy, but one that delivers signals that are ... scattering, and 100 times stronger than obtained from ...
(Date:7/22/2014)... cost-effectiveness analysis of commercial diet programs and pills, the ... best value for the money. The Jenny Craig regimen ... most expensive option tested, according to researchers at Duke-National ... findings, published in the June issue of the journal ... and weight-loss benefits per dollar spent as insurance carriers ...
Breaking Biology News(10 mins):Researchers create vaccine for dust-mite allergies 2Enhanced NIST instrument enables high-speed chemical imaging of tissues 2Enhanced NIST instrument enables high-speed chemical imaging of tissues 3Study compares cost-effectiveness of weight-loss programs and drugs 2Study compares cost-effectiveness of weight-loss programs and drugs 3
... New discoveries by researchers at the University ... a first-ever pharmacological treatment for cocaine addiction. ... to treat people with hypertension and anxiety, has ... from retrieving memories associated with cocaine use in ...
... , STONY BROOK, NY"Trophic Downgrading of Planet Earth," a review ... the journal Science, concludes that the decline of ... is causing substantial changes to Earth,s terrestrial, freshwater, and marine ... from ecosystems "may be humankind,s most pervasive influence on nature." ...
... achieved a pivotal breakthrough in the development of a cable ... possible. Armchair quantum wire (AQW) will be a weave ... over long distances. It will be an ideal replacement for ... 5 percent per 100 miles of transmission, said Rice chemist ...
Cached Biology News:UWM research offers hope for treatment of cocaine addiction 2Loss of top animal predators has massive ecological effects 2Loss of top animal predators has massive ecological effects 3'Amplified' nanotubes may power the future 2'Amplified' nanotubes may power the future 3
(Date:7/22/2014)... solution of rod-shaped metal nanoparticles in water with ultrasound ... drill bits. Why? No one yet knows exactly. But ... (NIST) have clocked their speedand it,s fast. At up ... times faster than any nanoscale object submerged in liquid ... has opened up the possibility that they could be ...
(Date:7/22/2014)... DALLAS , July 22, 2014   ... replacement therapy using natural, bio-identical hormone pellets, today ... , MD to the company.   Dr. Rouzier is ... training physician.      Dr. Rouzier was ... at UCLA and is a board certified emergency ...
(Date:7/22/2014)... CTD Holdings, Inc. (OTCQB:CTDH), a manufacturer and ... and other markets, announced today that it has closed ... private investors led by Novit L.P., an investment arm ... involved the signing of a Securities Purchase Agreement under ... at a price per share of $1.00, resulting in ...
(Date:7/22/2014)... Rice Lake, Wisconsin (PRWEB) July 22, 2014 ... will be in attendance at the 2014 NCSL ... Florida. Booth #423 will feature CONDEC pressure ... balance style weights, and the new, customized sets, ... years ago to promote cooperative efforts in solving ...
Breaking Biology Technology:NIST shows ultrasonically propelled nanorods spin dizzyingly fast 2Dr. Neal Rouzier Joins BioTE Medical 2Dr. Neal Rouzier Joins BioTE Medical 3CTD Holdings Closes $1.725 Million Private Placement 2CTD Holdings Closes $1.725 Million Private Placement 3Rice Lake Weighing Systems Showcases Metrology Solutions for the 2014 NCSL International Workshop & Symposium 2
... Dr. Kyong S. Choe, of Kwangju, South Korea, has been ... outstanding contributions and achievements in the field of healthcare. ... Dr. Choe is currently practicing with Feldman, Fitzgerald ... periodontics and prosthodontics targeting implants and full prosthetic reconstruction.  He ...
... on Tel Aviv Stock Exchange. - Common Stock to List on both Tel ... the Ticker Symbol PLX -,- Company Anticipates Joining TASE,s TA-75, TA-100, Tel-Tech, Tel-Tech ... to Dual List on Tel Aviv Stock Exchange -- CARMIEL, Israel, Aug. 30 ... ...
... August 30, 2010 ... if ... var shortURL = ""; BitlyCB.alertResponse = ... to grab the first one. for (var r in data.results) { first_result = data.results[r]; break; } for ...
Cached Biology Technology:Dr. Kyong S. Choe Recognized by Strathmore's Who's Who Worldwide Publication 2Protalix BioTherapeutics to Dual List on Tel Aviv Stock Exchange 2Protalix BioTherapeutics to Dual List on Tel Aviv Stock Exchange 3Protalix BioTherapeutics to Dual List on Tel Aviv Stock Exchange 4Protalix BioTherapeutics to Dual List on Tel Aviv Stock Exchange 5Protalix BioTherapeutics to Dual List on Tel Aviv Stock Exchange 6Protalix BioTherapeutics to Dual List on Tel Aviv Stock Exchange 7Protalix BioTherapeutics to Dual List on Tel Aviv Stock Exchange 8Teriflunomide Significantly Reduced Annualized Relapse Rate and was Well Tolerated in MS Patients 2Teriflunomide Significantly Reduced Annualized Relapse Rate and was Well Tolerated in MS Patients 3Teriflunomide Significantly Reduced Annualized Relapse Rate and was Well Tolerated in MS Patients 4Teriflunomide Significantly Reduced Annualized Relapse Rate and was Well Tolerated in MS Patients 5Teriflunomide Significantly Reduced Annualized Relapse Rate and was Well Tolerated in MS Patients 6Teriflunomide Significantly Reduced Annualized Relapse Rate and was Well Tolerated in MS Patients 7Teriflunomide Significantly Reduced Annualized Relapse Rate and was Well Tolerated in MS Patients 8Teriflunomide Significantly Reduced Annualized Relapse Rate and was Well Tolerated in MS Patients 9
HSV-2 gD (0191)...
...
...
RayBio Human Angiogenesis Antibody Array 2.1 (8 array membranes) with Accessory, detects 23 angiogenic factors (for lysate) Class: Antibody Array Products Product Group: Antibody Array...
Biology Products: