David Sabatini, an associate professor at the Massachusetts Institute of Technology and a Howard Hughes Medical Institute investigator, won the Earl and Tressa Stadtman Scholar Award, given to a scientist with 10 years or less of post-postdoctoral experience, including medical residency and fellowship. Sabatini is a leader in the ongoing elucidation of the mTOR pathway, a master regulator of growth. He is also a member of the Whitehead Institute for Biomedical Research.
Kim Orth, a professor at the University of Texas Southwestern Medical Center at Dallas, has been named the winner of the ASBMB Young Investigator Award. Orth's most notable achievements include the discovery of novel posttranslational modifications exploited by the virulence factors secreted by bacterial pathogens. One of these, YopJ from Yersinia, the causal agent of the Plague, transfers an acetyl group from acetyl CoA to a serine or threonine hydroxyl in mammalian MAP kinase kinase, inactivating the enzyme. Another virulence factor, VopS from Vibrio parahaemolyticus, a cause of debilitating diarrhea, is an enzyme that AMPylates (transfers AMP) to tyrosine, serine or threonine hydroxyl in mammalian Rho GTPases, inactivating these enzymes. Her studies bring new insights to the field of eukaryotic signaling.
Judith Voet, professor emeritus at Swarthmore College, and Donald Voet, associate professor at the University of Pennsylvania, won the ASBMB Award for Exemplary Contributions to Education. The Voets have made significant contributions to the teaching of biochemistry and m
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American Society for Biochemistry and Molecular Biology