Navigation Links
1 step closer to closure
Date:12/28/2009

Spinal cord disorders like spina bifida arise during early development when future spinal cord cells growing in a flat layer fail to roll up into a tube. In the Dec. 6 issue of Nature Cell Biology, researchers from the Johns Hopkins University School of Medicine team with colleagues at the University of California, Berkeley to report a never-before known link between protein transport and mouse spinal cord development, a discovery that opens new doors for research on all spinal defects.

"What I love about this discovery is the total surprise we never before would have linked defects in the protein-secretion machinery and neural tube closure," says David Ginty, Ph.D., professor of neuroscience and Howard Hughes Medical Institute investigator.

The team originally set out to find new genes that instruct proper wiring of the hundred billion neurons in the nervous system. To do that, they randomly generated mutations in mouse genes, bred the mice and examined offspring for defects in nervous system development. One of the thousands of mouse embryos examined by graduate student Janna Merte had a spinal cord that had failed to close into a tube. Whereas conditions like spina bifida arise from failure of the tail end of the spinal cord to close, these new mice had a more severe condition, where the entire length of the spinal tube had failed to close.

Intrigued, Janna then identified the mutated gene in this mouse as Sec24b, a gene already known to play a role in the process where cells package newly made proteins that are destined to be delivered to the cell membrane or sent to the outside of the cell. But all genes known to instruct normal spinal tube closure are known to orient cells in a flat sheet, similar to patterning of the hair follicles in skin.

"We didn't really know what to do with Sec24b at first," says Ginty. His team consulted and eventually teamed up with Berkeley professor Randy Schekman, who discovered the
'/>"/>

Contact: Audrey Huang
audrey@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related biology news :

1. Gene regulation in humans is closer than expected to simple organisms
2. UK scientists lead China closer to carbon capture and storage
3. Cheaper drugs now closer to realization with new DropArray technology
4. Researchers move 2 steps closer to understanding genetic underpinnings of autism
5. Bees disease -- 1 step closer to finding a cure
6. Footrot vaccine closer than ever
7. Scientists a step closer to producing fuel from bacteria
8. Green chemicals closer to market
9. Study finds DNA barcoding requires caution without closer examination
10. Scientists closer to developing salt-tolerant crops
11. Scientists closer to making implantable bone material, thanks to new research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/29/2014)... Energy Joint Genome Institute (DOE JGI), a DOE ... 32 new projects have been selected for the ... lakes to Caribbean waters, and from plant root ... in forested watersheds, the CSP 2015 projects portfolio ... be extracted. , "These projects catalyze JGI,s ...
(Date:9/29/2014)... who lived 2,330 years ago in the southernmost tip of ... when his DNA profile is one of the ,earliest diverged, ... region where modern humans are believed to have originated roughly ... ,mitochondrial DNA, was sequenced to provide clues to early modern ... that we all come from Africa, and helps us map ...
(Date:9/29/2014)... Ill. Scientists have discovered a previously unknown ... grow and, in the case of estrogen-positive breast ... work reveals new targets for breast cancer therapy ... the most aggressive treatment. , The University of ... Oncogene . , Estrogen pre-activates the unfolded-protein ...
Breaking Biology News(10 mins):2015 DOE JGI's science portfolio delves deeper into the Earth's data mine 22015 DOE JGI's science portfolio delves deeper into the Earth's data mine 32015 DOE JGI's science portfolio delves deeper into the Earth's data mine 42015 DOE JGI's science portfolio delves deeper into the Earth's data mine 52015 DOE JGI's science portfolio delves deeper into the Earth's data mine 62015 DOE JGI's science portfolio delves deeper into the Earth's data mine 72015 DOE JGI's science portfolio delves deeper into the Earth's data mine 82015 DOE JGI's science portfolio delves deeper into the Earth's data mine 9Ancient human genome from southern Africa throws light on our origins 2Ancient human genome from southern Africa throws light on our origins 3Scientists discover a new role for estrogen in the pathology of breast cancer 2
... Hopkins researchers have created a synthetic protein that, when activated ... body where cancer, arthritis and other serious medical disorders can ... type of diagnostic imaging technology and may someday serve as ... where signs of disease have been found. In a study ...
... mood for food can be changed by a restaurant,s choice ... calorie intake, according to a new study., "When we did ... music and lighting led diners to eat 175 fewer calories ... Wansink, professor of marketing and director of Cornell University,s Food ...
... FARMINGTON, Conn., Aug. 29, 2012 /PRNewswire-iReach/ -- The biobanking market ... new drug and treatment development for specific diseases. The ... and is projected to increase by 30% between 2010 and ... Private sector biobanks will experience the greatest increase with growth ...
Cached Biology News:Collagen-seeking synthetic protein could lead doctors to tumor locations 2Collagen-seeking synthetic protein could lead doctors to tumor locations 3Global Biobanking Market Projected to Increase by 30% to Reach $183 Billion by 2015 2Global Biobanking Market Projected to Increase by 30% to Reach $183 Billion by 2015 3
(Date:9/29/2014)... ZIONA, Israel , September 29, 2014 ... company developing novel immunomodulators for severe infections, today announced ... BARDA ) has awarded Atox Bio with a contract ... the development of AB103 to treat Necrotizing Soft Tissue ... public health threats that end in sepsis. ...
(Date:9/29/2014)... September 29, 2014 Florais de Saint ... its natural and soul-enhancing floral essences to the United ... essences into special formulas to help with specific treatments ... physical, mental, and emotional health. , “This is truly ... discoveries being made every day on how to properly ...
(Date:9/27/2014)... special section on single-photon detection, generation, and applications ... technologies with applications in areas as diverse as ... by providing more accurate measurement methods and new ... SPIE, the international society for optics and photonics, ... , The section appears in the August issue, ...
(Date:9/26/2014)... 2014 Synedgen announced today the ... (SBIR) Phase I contract from the National Cancer ... (NIH) to demonstrate proof-of-concept activity of Synedgen’s proprietary ... painful tissue damage to the lining of the ... this award, Synedgen will complete efficacy studies for ...
Breaking Biology Technology:Atox Bio Awarded Contract Worth up to $24 Million for the Development of AB103 by the Biomedical Advanced Research and Development Authority (BARDA) 2Florais de Saint Germain Brings New Kind of Flower Power To America 2Single-photon detection, generation, and applications featured in Optical Engineering 2Single-photon detection, generation, and applications featured in Optical Engineering 3Synedgen Awarded National Cancer Institute Funding for Promising New Treatment for Medical Radiation-induced Bowel Injury 2
... , , SAN FRANCISCO, Aug. 4 Nile ... the development of novel therapeutics for heart failure patients, today announced ... of its lead product, CD-NP, for the treatment of acute heart ... study is designed to provide additional information on the safety and ...
... /PRNewswire-FirstCall/ - Oncothyreon Inc. (Nasdaq: ONTY ) ... Hausman, M.D., as Vice President, Clinical Development at Oncothyreon. ... planning and implementing the clinical development program for the ... is an experienced oncologist who brings an extensive background ...
... , PALO ALTO, Calif., August ... antiviral therapies, announced today that it has licensed the exclusive ... Stanford University. This technology, discovered in the lab of Stanford ... focused on a variety of novel targets, including key features ...
Cached Biology Technology:Nile Therapeutics, Inc. Announces Dosing of First Patient in Phase 2 Study of CD-NP for the Treatment of Acute Heart Failure 2Nile Therapeutics, Inc. Announces Dosing of First Patient in Phase 2 Study of CD-NP for the Treatment of Acute Heart Failure 3Oncothyreon appoints Diana Hausman as Vice President of Clinical Development 2Oncothyreon appoints Diana Hausman as Vice President of Clinical Development 3Eiger BioPharmaceuticals Acquires Exclusive License to Novel Hepatitis C Virus (HCV) Technology From Stanford University 2
...
One-step, microplate or cuvet, colorimetric, detection range 0.3 g/dL to 5 g/dL. Procedure: 5 min....
Donor Goat Serum...
The Varian 4000 GC/MS system offers three easily switchable ionization configurations: internal ionization (II), external ionization (EI) or hybrid chemical ionization (CI)...
Biology Products: