Navigation Links
1 step closer to a drug treatment for cystic fibrosis, MU professor says
Date:10/12/2010

COLUMBIA, Mo. A University of Missouri researcher believes his latest work moves scientists closer to a cure for cystic fibrosis, one of the world's most common fatal genetic diseases.

The Journal of Biological Chemistry has published findings by Tzyh-Chang Hwang, a professor in the School of Medicine's Department of Medical Pharmacology and Physiology and the Dalton Cardiovascular Research Center. The publication has been recognized as the "paper of the week" for the journal, meaning Hwang's work is considered to be in the top 1 percent of papers reviewed annually in terms of significance and overall importance.

Hwang's work focuses on the two most common genetic mutations among approximately 1,500 mutations found in patients with cystic fibrosis. These two mutations cause specific chloride channels in the cell, known as the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) chloride channels, to malfunction. This ultimately leads to repeated pneumonia, the primary cause of most deaths associated with cystic fibrosis.

"The normal function of a cell is to pass chloride ions across the cell membrane at a very fast speed," Hwang said. "We know some signaling molecules elicit this reaction, much like a hand signals an automatic water faucet to dispense water. But in the case of cystic fibrosis, that signal is no longer detected by the mutated channel protein. Through some mechanisms we still don't quite understand, malfunction of this channel protein eventually leads to bacterial infection in the lung, which is believed to be responsible for the most severe symptoms of cystic fibrosis."

The most recent study found that manipulating the sensor of the channel protein can significantly rectify the malfunction of the mutated channel, thus opening the door to a drug design that may eventually be a "real cure," Hwang said.

"We could help a lot of patients if we can utilize the power of computer simulations and
'/>"/>

Contact: Steven Adams
AdamsST@missouri.edu
573-882-8353
University of Missouri-Columbia
Source:Eurekalert

Page: 1 2

Related biology news :

1. Plant scientists move closer to making any crop drought-tolerant
2. Solid oxide fuel cells getting closer to the market
3. Gene therapy a step closer to mass production
4. Research is getting closer to understanding critical nucleus in haze formation, prof says
5. Genome BC, Chile and Norway take another step closer to fully sequencing the salmon genome
6. Low-cost, ultra-fast DNA sequencing brings diagnostic use closer
7. For osteoporosis patients, exercise pill one step closer to reality
8. Bringing better grapes a step closer to reality
9. Cold fusion moves closer to mainstream acceptance
10. 1 step closer to closure
11. ESA and World Bank move toward closer collaboration
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/2/2015)... Sweden , April 2, 2015 ... its touch fingerprint sensor FPC1025 from the distributor World ... will commence during Q2 2015 although the major part ... The sensors will be used by smartphone manufacturers in ... 110 MSEK is included in the communicated revenue guidance ...
(Date:4/1/2015)... BOSTON , April 1, 2015   Medisafe ... 1.5 million users across iOS and ... has begun integrating biofeedback into the platform to allow ... health outcomes. For the first time, patients will be ... missing a dose impacts important biometrics, such as glucose ...
(Date:3/31/2015)... --  Guidepoint , a leading global research services firm, ... TRACKER, part of the Guidepoint TRACKER suite ... device and therapeutics markets. The Post-Surgical Pain Management TRACKER ... share, and adoption rates across three major modalities used ... The Post-Surgical Pain Management TRACKER will provide length ...
Breaking Biology News(10 mins):Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 110 Million 2Medisafe Announces Launch of Biometric Integration, Enabling Patients to Stay Adherent to Their Meds and See Tangible Health Results 2Guidepoint Launches Post-Surgical Pain Management TRACKER 2Guidepoint Launches Post-Surgical Pain Management TRACKER 3
... from engineers at Rensselaer Polytechnic Institute and the University of ... powerful new tool for manipulating cells. Results of the study, ... blue light can be used as a switch to prompt ... process of clustering, or oligomerization, is commonly employed by nature ...
... Securing the future supply of food is a major challenge ... food chain continues to supply, safe healthy food to the ... become scarcer? This is the focus of the IFST Spring ... on the Norwich Research Park, 17-18 April. A range ...
... coal power stations could be drastically reduced by a ... dioxide, then releases it when exposed to sunlight. ... , Monash University and CSIRO scientists for the first ... a class of materials known for their exceptional capacity ...
Cached Biology News:Nature Methods study: Using light to control cell clustering 2Carbon sponge could soak up coal emissions 2
(Date:5/1/2015)... DIEGO , May 1, 2015 ... company engaged in the development of biosimilar therapeutics ... announced today that its first quarter 2015 financial ... 2015, before the open of market. At 8:30 am ... call to discuss the financial results and provide ...
(Date:5/1/2015)... 1, 2015 Albany Molecular Research Inc. (NASDAQ: ... Marth , AMRI,s President and Chief Executive Officer, will ... Health Care Conference on Wednesday, May 13, 2015 at ... of the presentation can be accessed at AMRI,s Investor ... The webcast will be archived for 90 days following ...
(Date:4/30/2015)... 2015  Roka Bioscience, Inc. (NASDAQ: ROKA ), ... solutions for the detection of foodborne pathogens, announced plans ... of 2015 on May 7, 2015 after the close ... also host a conference call at 4:30 p.m. Eastern ... quarter financial results. During the conference call, material information ...
(Date:4/30/2015)... 30, 2015 Nitto Avecia, a ... its increased capacity and production capability to serve ... variety and service fulfillment continues to drive Nitto ... process throughput capacities. , In Fall ... downstream process equipment at its Milford, MA facility, ...
Breaking Biology Technology:Pfenex To Report First Quarter 2015 Results and Provide Business Update on Thursday, May 14, 2015 2AMRI to Present at the Bank of America Merrill Lynch 2015 Health Care Conference 2Roka Bioscience to Report First Quarter 2015 Financial Results On May 7, 2015 2Biotechnology Manufacturer Nitto Avecia Expands Capacity to Meet Client Demand 2
... Wireless Facilities, Inc. , a global ... communication networks, technology networks and security systems, announced today ... and deployment services for the City of Madison, Wisconsin's ... company Cellnet, and in coordination with Madison Gas & ...
... -- A former paper converting plant in this southwestern Wisconsin ... push to become a major global player in radio frequency ... various types of labels and thermal transfer ribbons ... by the technology. The labels are intended to add efficiencies ...
... CHICAGO Anyone following this column over the last few ... allow me to arrange information into tidy boxes in some ... sense out of the information for myself). While my list ... about how lists could be used to create awareness and ...
Cached Biology Technology:Wisconsin plant is part of NCR's global RFID initiative 2Wisconsin plant is part of NCR's global RFID initiative 3Wisconsin plant is part of NCR's global RFID initiative 4Though Weakening, Biotech IPO Market Still Viable, Burril & Co. Says 2Though Weakening, Biotech IPO Market Still Viable, Burril & Co. Says 3Though Weakening, Biotech IPO Market Still Viable, Burril & Co. Says 4
... is compatible with BioTeks microplate washers, ... of use and walkaway automation are ... When used with the ELx405 washer ... Bio-Stacks small footprint fits easily in ...
... use of small interfering RNA (siRNA) molecules ... interference (RNAi) pathway have generated tremendous interest ... siRNA for experimental use can be synthesized ... then transfected into the target cells in ...
... for the use of small interfering RNA ... the RNA interference (RNAi) pathway have generated ... biology fields. siRNA for experimental use can ... enzymatically, and then transfected into the target ...
... is commonly used as a fusion partner ... The GSTTag sequence has been reported to ... the solubility of its fusion partners. When ... GSTTag fusion proteins can be purified with ...
Biology Products: