Navigation Links
1 of the key circuits in regulating genes involved in producing blood stem cells is deciphered
Date:1/31/2013

Researchers from the group on stem cells and cancer at IMIM (Hospital del Mar Medical Research Institute) have deciphered one of the gene regulation circuits which would make it possible to generate hematopoietic blood cells, i.e. blood tissue stem cells. This finding is essential to generate these cells in a laboratory in the future, a therapy that could benefit patients with leukaemia or other diseases who need a transplant and who, in many cases, do not have a compatible donor.

In the process of generating stem cells, many molecule signals intervene which, through a regulating circuit are induced at a certain moment and remain active during a specific time until they switch off so these cells can differentiate. Anna Bigas, the coordinator of the research group on stem cells and cancer at IMIM explains: "We discovered that the Notch protein, which is involved in the development of most tissues, is responsible for activating the gene GATA2 which is necessary to generate hematopoietic stem cells; at the same time, it induces the reproduction of its own repressor, HES-1". The team lead by Bigas has also shown that this regulating circuit allows the limited production of GATA2, and this is essential for the production of hematopoietic stem cells.

The study was developed over 4 years and consisted in performing a large number of experiments with the collaboration of groups from Japan, Holland and the USA. On the one hand, researchers identified the mechanism regulating the gene GATA2 in hematopoietic stem cells of a mouse embryo and, on the other hand, they identified DNA sequences regulating this gene; i.e. the sequences of gene GATA2 where the Notch protein and the repressor HES-1 bind. After generating several mutations in these sequences, researchers saw that if the Notch protein does not bind to GATA 2, the gene is not activated, whereas if it's the repressor HES-1 that doesn't bind to it, then there is an over-production of the protein GAT
'/>"/>

Contact: Marta Calsina
mcalsina@imim.es
34-933-160-680
IMIM (Hospital del Mar Medical Research Institute)
Source:Eurekalert

Page: 1 2

Related biology news :

1. Computers taught to ID regulating gene sequences
2. BUSM study identifies receptors role in regulating obesity, type 2 diabetes
3. Scientists identify mechanism for regulating plant oil production
4. New screening technique yields elusive compounds to block immune-regulating enzyme
5. Evidence mounts for role of mutated genes in development of schizophrenia
6. First in the world - Singapore scientists discover genes responsible for cornea blindness
7. A history lesson from genes
8. International study suggests human genes influence gut microbial composition
9. Rare form of active jumping genes found in mammals
10. More than 200 genes identified for Crohns Disease
11. Steroid hormone receptor prefers working alone to shut off immune system genes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2015)... 2015 Genisphere announced Tom ... help further develop Genisphere,s therapeutics capabilities and portfolio. Mr. ... spent much of the last 25 years in leadership ... and Johnson & Johnson. Tom started his career in ... Corporate Finance. He graduated from Dartmouth College with a ...
(Date:6/25/2015)...  Imagine a tool specifically designed to help you ... That,s exactly what USANA,s True Health Assessment ... health program provides a personalized approached to measuring your ... lifestyle and nutrition. At the Canadian ... USANA,s THA was honored with the Industry Innovation Award. ...
(Date:6/24/2015)... Calif. , June 24, 2015  Synaptics ... of human interface solutions, today announced that Sharp ... to provide secure authentication for its latest flagship ... reached more than 200 million shipments of its ... Sharp reinforces Synaptics, strength, scalability and leadership in ...
Breaking Biology News(10 mins):Genisphere Appoints New CEO, Thomas Bliss 2Genisphere Appoints New CEO, Thomas Bliss 3@USANAinc's Personalized Nutrition Program Wins Industry Innovation Award 2Synaptics Brings Natural ID Technology to Sharp's Newest Flagship Smartphone 2
... 9 June 2008 Elsevier, a world-leading publisher ... services, is pleased to announce the publication of ... for radical hypotheses on topics throughout the life ... to stimulate innovation by choosing work that is ...
... online journal Marine Drugs , state that an ... sea lions can result from low-dose exposure to domoic ... earlier this year led by Frances Gulland of the ... to be a newly recognized chronic disease. John ...
... influences the chances of having male or female offspring. ... Reproductive Biology and Endocrinology has demonstrated that ewes fed ... prior to conception have a significantly higher chance of ... carried out by a team of researchers from the ...
Cached Biology News:Elsevier launches Bioscience Hypotheses 2Domoic acid from toxic algal blooms may cause seizures in California sea lions 2Diet prior to pregnancy determines sheep's gender 2
(Date:7/29/2015)... July 29, 2015  Pfenex Inc. (NYSE MKT: PFNX) ... will be released on Thursday, August 13, 2015, before ... Pfenex management will host a conference call to discuss ... press release outlining the financial results and business update ... Please call 1-866-376-8058 (US) or 1-412-542-4131 (international) and ...
(Date:7/29/2015)... ... July 29, 2015 , ... Finding gooey or crusty material in ... Although there are a considerable number of terms in popular use to describe it, ... is a mixture of mucus, blood cells, skin cells and dust, but until now ...
(Date:7/29/2015)... ... July 29, 2015 , ... Asymmetrex, LLC ... in evaluating the full range of capabilities of its unique cache of technologies ... perform the day-to-day renewal and repair of normal tissues and organs. This property ...
(Date:7/28/2015)... VILLAGE, Nev. , July 28, 2015  PDL ... ) today announced that the Company will release its ... June 30, 2015, on Wednesday, August 5, 2015, after ... and webcast that day at 4:30 p.m. Eastern Time ... to the call will be available via the webcast ...
Breaking Biology Technology:Pfenex To Report Second Quarter 2015 Results and Provide Business Update on Thursday, August 13, 2015 2What Are ‘Eye Crusties’ Made Of? uBiome Invites Citizen Scientists to Find Out 2What Are ‘Eye Crusties’ Made Of? uBiome Invites Citizen Scientists to Find Out 3What Are ‘Eye Crusties’ Made Of? uBiome Invites Citizen Scientists to Find Out 4Asymmetrex Plans to Report Results From Adult Stem Cell Technology Development Milestone Studies At End of Summer 2Asymmetrex Plans to Report Results From Adult Stem Cell Technology Development Milestone Studies At End of Summer 3Asymmetrex Plans to Report Results From Adult Stem Cell Technology Development Milestone Studies At End of Summer 4PDL BioPharma to Announce Second Quarter 2015 Financial Results on August 5, 2015 2
... EUGENE, Ore. -- (Sept. 21, 2011) -- University of ... to account for often-missing thermodynamic and molecular parameters in ... atomistic-level data into the time frame of the macroscopic ... of regular publication in the journal Physical Review ...
... combines both graphene and SWNTs, Graphene Nanoribbons encapsulated ... by researchers from Aalto University (Finland) and Umea ... attracted enormous interest from a broad range of ... to create a novel hybrid material, which combines ...
... Building, validating, and maintaining a controlled environment facility ... 2011, hosted by Microtest Laboratories at the MIT Endicott House ... Clean? The Building Blocks of Facility Control ," the ... disinfection validation , and related contamination testing issues that ...
Cached Biology Technology:Catching molecular motion at just the right time 2Catching molecular motion at just the right time 3New hybrid carbon material discovered 2Building, Validating & Maintaining Controlled Environment Facilities is Focus of Oct. 18th Seminar in Boston Hosted by Microtest Laboratories 2
...
... Rabbit Polyclonal to Human CELSR3 CELSR3 is ... In mouse, this gene is expressed during ... adult mice and rats in brain, spinal cord, ... isolated from human B-cell/lung/testis, blood, brain, colon, heart/melanocyte/uterus, ...
... plus multi-channel focal drug delivery. Maintain bath ... high-flow bath line while quickly switching 4 ... Pencil.® Steady 37°C at 5 ml/minute flow ... tip. Advanced auto-tuning temperature lock ...
... Immunogen: purified recombinant human ... coli . Physical form: ... filtered solution in phosphate buffered ... (c). WB. Titertest ...
Biology Products: