Navigation Links
'1-hit' event provides new opportunity for colon cancer prevention, say Fox Chase researchers
Date:9/14/2008

PHILADELPHIA (September 15, 2008) More than 30 years ago, Alfred Knudson Jr., M.D., Ph.D., revolutionized the field of cancer genetics by showing that a person must lose both their paternal and maternal copies of a particular class of cancer-inhibiting genes, called tumor-suppressor genes, in order to develop cancer. This theory, called the two-hit hypothesis, guided scientists around the globe in their quest for tumor suppressor genes. Now Knudson, a Fox Chase Cancer Center Distinguished Scientist and senior advisor to the Center president, and colleagues offer evidence that a "one-hit" event is enough to change the cells and increase the likelihood they would become cancerous.

By studying people who have inherited the first hit in every cell in the body, the Fox Chase researchers believe they may have discovered a source for some of the earliest known molecular changes that signal the presence of colorectal cancer, the second leading cause of cancer-related death in the United States. Their findings are presented in the September 15 issue of the journal Cancer Research.

"We hypothesized that an inherited one-hit gene mutation can, by itself, lead to changes in the proteins of normal-looking cells" says Anthony Yeung, Ph.D., lead author of the paper and a tenured member of the Fox Chase scientific staff. "While these cells are just another hit away from becoming cancerous, their altered patterns of protein production may represent new biomarkers of cancer and novel targets for preventive and therapeutic drugs a chance to strike at cancer before a second hit can happen."

The Fox Chase researchers studied patients with familial adenomatous polyposis (FAP), an inherited disorder that also serves as a classic model in support of the two-hit hypothesis. Patients with FAP, which predisposes people to colon cancer, carry mutations in one of their two copies of the adenomatous polyposis coli (APC) tumor-suppressor gene. The APC gene acts to
'/>"/>

Contact: Greg Lester
gregory.lester@fccc.edu
215-316-8977
Fox Chase Cancer Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Controlling for size may also prevent cancer
2. Avocados may help prevent oral cancer, OSU study shows
3. Dietary calcium could possibly prevent the spread of breast cancer to bone
4. Bilberry extract -- can it help prevent certain cancers?
5. Preventing tuberculosis reactivation
6. NIH hosts event to launch Council of Science Editors global theme issue
7. Knocking out cell receptor may help block fat deposits in tissues, prevent weight gain
8. Scripps research team blocks bacterial communication system to prevent deadly staph infections
9. Frontiers in Cancer Prevention Research
10. NASA technology helps predict and prevent future pandemic outbreaks
11. Childrens Hospital studying drug with the potential to prevent/delay onset of type 1 diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/5/2014)... career to understanding the Earth,s climate and communicating ... deputy director and regional climatologist for the Western ... Redmond has more than three decades of experience ... data to the general public. , At its ... December 15-19, 2014 the American Geophysical Union (AGU) ...
(Date:11/4/2014)... 2014) — Think about the way our bodies are ... cells know that they are supposed to become a ... tissues find the correct place and alignment? Researchers at ... questions. , In a new study, UM researchers describe ... their surrounding neighbors, at the head-trunk region. Their discovery ...
(Date:11/3/2014)... -- Research and Markets has announced the addition ... and Companies" to their offering. This ... have already started to play an important role in the ... old fashioned bone marrow transplants. Role of cells in drug ... a part of medical practice. Stem cells are ...
Breaking Biology News(10 mins):Nevada climatologist to be honored at AGU Fall Meeting for lifetime of public outreach 2The inside story: How the brain and skull stay together 2Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 2Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 3
... (14 October 2011) On a continent battered by weather ... today from the World Agroforestry Centre documents an exciting ... farmers in Southern Africa are now significantly boosting yields ... shrubs to naturally fertilize their fields. The analysis ...
... the first time have identified and mapped the chemical structure ... kill or inhibit the growth of reef-building coral. Chemicals ... been shown to harm coral, suggesting that competition with these ... and lack of recovery of coral reefs. Seaweed ...
... at The University of Texas at Austin whose technology developments ... treat tens of thousands of patients with diseases such as ... the Institute of Medicine (IOM). Established in 1970, IOM ... the institute is considered one of the highest honors in ...
Cached Biology News:400,000 farmers in southern Africa using 'fertilizer trees' to improve food security 2400,000 farmers in southern Africa using 'fertilizer trees' to improve food security 3Study identifies molecules used by certain species of seaweed to harm corals 2Study identifies molecules used by certain species of seaweed to harm corals 3Study identifies molecules used by certain species of seaweed to harm corals 4UT professor elected to the Institute of Medicine of the National Academies 2UT professor elected to the Institute of Medicine of the National Academies 3
(Date:11/26/2014)... , Nov. 26, 2014 The announced sales ... the company is looking to expand in non-healthcare areas, ... The healthcare market research firm says that  Siemens is ... Information,s biennial survey of the IVD market , with ... change in its composition would likely affect IVD market ...
(Date:11/26/2014)... (PRWEB) November 26, 2014 On January, ... the Baltimore and Washington D.C. science community to the ... The event, sponsored by the Protein Society, will take ... University Center, Room 312. Through discussion, presentations and ... structural importance of proteins, their role in the industry ...
(Date:11/26/2014)... November 25, 2014 Whitehouse Laboratories ... joined the Morris County (New Jersey) Chamber of ... a leading business organization in the North Jersey ... further engage some key clients in the pharmaceutical ... the geographic area. Membership enables Whitehouse Laboratories a ...
(Date:11/26/2014)... ADDISON, TX (PRWEB) November 25, 2014 ... age-defying skincare products, earned three prestigious MarCom Awards for ... , Nerium received a Platinum MarCom Award, the organization’s ... Real Event in St. Louis held in April of ... for more than 14,000 attendees. Additionally, Nerium was awarded ...
Breaking Biology Technology:Kalorama: Sale of Three Siemens Healthcare Units Raises Questions About Firm's IVD Future 2Whitehouse Laboratories Joins Morris County Chamber of Commerce 2Whitehouse Laboratories Joins Morris County Chamber of Commerce 3Nerium International™ Wins One Platinum, Two Gold MarCom Awards 2
... Abstract , ... RNA from biological sources such as cultured cells. These techniques eliminate ... produce a highly pure product, free of PCR inhibitors, that is ... These new techniques respond to the demand for high-quality, highthroughput total ...
... Overview , Mass ... peptide synthesis. Matrix Assisted Laser Desorption Ionization (MALDI) Time-of-Flight (TOF) MS is ... relatively little maintenance. This work shows the ability of MALDI-TOF MS to ... presented by A. Falick, G. Tarr and N. Sole at ABRF 96. ...
... Reverse transcription-polymerase chain reaction (RT-PCR) ... double-stranded DNA product (1,2,3). RT-PCR is a powerful tool ... splice variants. RT-PCR is generally carried out as either one-step ... and RT and PCR are conducted sequentially in this tube ...
Cached Biology Technology:Total RNA Purification from Cultured Cells Using the ABI PRISM 6700 Automated Nucleic Acid Workstation and Total RNA Lysis Reagents 2Total RNA Purification from Cultured Cells Using the ABI PRISM 6700 Automated Nucleic Acid Workstation and Total RNA Lysis Reagents 3Total RNA Purification from Cultured Cells Using the ABI PRISM 6700 Automated Nucleic Acid Workstation and Total RNA Lysis Reagents 4Total RNA Purification from Cultured Cells Using the ABI PRISM 6700 Automated Nucleic Acid Workstation and Total RNA Lysis Reagents 5Total RNA Purification from Cultured Cells Using the ABI PRISM 6700 Automated Nucleic Acid Workstation and Total RNA Lysis Reagents 6Direct Monitoring of Solid-Phase Peptide Synthesis by MALDI-TOF MS 2Direct Monitoring of Solid-Phase Peptide Synthesis by MALDI-TOF MS 3Simple Approaches for Optimization of RT-PCR 2Simple Approaches for Optimization of RT-PCR 3Simple Approaches for Optimization of RT-PCR 4Simple Approaches for Optimization of RT-PCR 5
Supplemental reagent for annexin V assay....
Antibody Purification Specificity: Antibody Purification ...
Large-fragment, single-stranded carrier DNA of the highest quality, perfectly suited for all types of yeast transformation....
Ultra-sensitive, non-radioactive detection of rat Big Endothelin-1 (Big ET-1)...
Biology Products: