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Scientists make important step toward stopping plaque-like formations in Huntington's disease
Date:5/21/2010

th Huntington's disease. The scientists employed two methods to survey a large number of genes: automated microscopy for imaging the plaque-like protein aggregates in the cells at a high-magnification level, and a computer-assisted method to quantify information on the aggregates in each tested sample. By integrating these methods, researchers were able to quickly examine all the approximately 14,000 fruit fly genes and identify the ones that are important for regulating the formation of aggregates by the mutant Huntington protein.

"The genetic overlap between humans and fruit flies continues to be a treasure trove for scientific discoveries," said Mark Johnston, Editor-in-Chief of GENETICS. "One hundred years ago, no one would have ever thought that research on a fly's brain could lead to medicines for human brains, but this research is a perfect example of this possibility."


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Contact: Tracey DePellegrin Connelly
td2p@andrew.cmu.edu
412-268-1812
Genetics Society of America
Source:Eurekalert

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