Navigation Links
Novel gene increases yeast's appetite for plant sugars
Date:7/26/2011

MADISON For thousands of years, bakers and brewers have relied on yeast to convert sugar into alcohol and carbon dioxide. Yet, University of Wisconsin-Madison researchers eager to harness this talent for brewing biofuels have found when it comes to churning through sugars, these budding microbes can be picky eaters.

Published online this week in the Proceedings of the National Academy of Sciences, a Great Lakes Bioenergy Research Center team identified several new genes that improve yeast's ability to use xylose, a five-carbon sugar that can make up nearly half of available plant sugars. If researchers can coax yeast into using most of these sugars, they can improve the efficiency of producing renewable fuels from biomass crops like corn stover or switchgrass.

"Strains of yeast that are currently used for biofuel production convert xylose to ethanol slowly and inefficiently, and only do so after all the glucose is exhausted," says the study's lead author Dana Wohlbach, a postdoctoral researcher at UW-Madison. "For industrial purposes, the faster a yeast can consume the sugars, the better, since more sugar consumption means more ethanol."

The team partnered with the Department of Energy Joint Genome Institute and sequenced the genomes of two types of fungi that reside in the habitats of bark beetles. Since woody biomass like bark contains a lot of xylose, these fungi were well adapted at using this type of sugar to both grow and also provide nutrients for the beetles.

Applying the power of comparative genomics to fungal ecology, scientists were able to rapidly identify genes that have potential for improving biomass conversion.

"By comparing the genome sequences and expression patterns of many yeasts rather than just looking at one we were able to identify elements common to all xylose-fermenting yeasts, and elements absent from non-xylose fermenting yeasts," says Wohlbach.

The team then introduced several genes into S. cerevisiae, which cannot normally consume xylose. By introducing one gene in particular, named CtAKR, the researchers significantly increased xylose consumption, an important step for economic biofuel production from plant material.

"This research has provided us with a great genomic toolset," says Wohlbach. "We're excited to explore new ways to increase yeast's ability to consume xylose and improve ethanol production for cellulosic biofuels."


'/>"/>

Contact: Margaret Broeren
mbroeren@glbrc.wisc.edu
608-890-2168
University of Wisconsin-Madison
Source:Eurekalert

Related biology news :

1. Scientists identify novel inhibitor of human microRNA
2. Conaway Lab identifies novel mechanism for regulation of gene expression
3. LIAI launches new division to look at novel approaches to heart disease and inflammation
4. Childrens National researchers develop novel anti-tumor vaccine
5. Cold Spring Harbor Laboratory scientists trace a novel way cells are disrupted in cancer
6. Novel publishing approach puts textbook in more hands
7. GEN reports on novel tools for deciphering biological networks
8. UT Southwestern researcher awarded Gates Foundation grant for novel vaccine development
9. 3-substituted indolones as novel therapeutic compounds for neurodegenerative conditions
10. Corn researchers discover novel gene shut-off mechanisms
11. A novel target for therapeutics against Staph infection
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/19/2016)... , UAE, April 20, 2016 ... be implemented as a compact web-based "all-in-one" system solution ... the biometric fingerprint reader or the door interface with ... of modern access control systems. The minimal dimensions of ... ID readers into the building installations offer considerable freedom ...
(Date:4/14/2016)... 14, 2016 BioCatch ™, ... today announced the appointment of Eyal Goldwerger ... Goldwerger,s leadership appointment comes at a time ... the deployment of its platform at several of the ... which discerns unique cognitive and physiological factors, is a ...
(Date:3/31/2016)... March 31, 2016  Genomics firm Nabsys has completed ... Barrett Bready , M.D., who returned to the ... original technical leadership team, including Chief Technology Officer, ... Development, Steve Nurnberg and Vice President of Software and ... company. Dr. Bready served as CEO of ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June 23, 2016   Boston Biomedical ... novel compounds designed to target cancer stemness pathways, ... been granted Orphan Drug Designation from the U.S. ... of gastric cancer, including gastroesophageal junction (GEJ) cancer. ... designed to inhibit cancer stemness pathways by targeting ...
(Date:6/23/2016)... Prostate Cancer Foundation (PCF) is pleased to announce 24 new Young ... cancer. Members of the Class of 2016 were selected from a pool of ... More About the Class of 2016 PCF Young Investigators ... ... ...
(Date:6/23/2016)... , ... June 23, 2016 , ... In a new ... in Denmark detail how a patient who developed lymphedema after being treated for breast ... results could change the paradigm for dealing with this debilitating, frequent side effect of ...
(Date:6/23/2016)... ... 23, 2016 , ... ClinCapture, the only free validated electronic ... showcase its product’s latest features from June 26 to June 30, 2016 for ... Disrupting Clinical Trials in The Cloud during the conference. DIA (Drug Information ...
Breaking Biology Technology: