Navigation Links
Hitting moving RNA drug targets
Date:6/26/2011

these results because one of the biggest challenges in RNA-targeted drug discovery is to be able to identify compounds that bind a specific RNA target without binding other RNAs. The ability of netilmicin to specifically bind TAR provides proof of concept for this new technology," said Stelzer.

Further experiments showed that, for the six potential drug molecules, the method not only successfully predicted that they would bind to TAR, it also showed---with atomic-level accuracywhere on the RNA molecule each drug would bind.

Al-Hashimi then turned the six drug candidates over to David Markovitz, a professor of infectious diseases at the U-M Medical School, who tested them in cultured human T cells infected with HIV. The point of this experiment was to see if the drugs would prevent HIV from making copies of itself, an essential step in the disease process.

"Netilmicin did in fact inhibit HIV replication," Markovitz said. "This result demonstrates that using an NMR spectrometer and some computers we can discover drugs that target RNA and are active in human cells."

In addition to testing compounds in existing molecular libraries, the virtual screening technique can be used to explore the potential of new compounds that have not yet been synthesized, Al-Hashimi said. "This opens up a whole new frontier for exploring RNA as a drug target and finding new compounds that specifically target it."


'/>"/>

Contact: Nancy Ross-Flanigan
rossflan@umich.edu
734-647-1853
University of Michigan
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Hitting target in cancer fight now easier with new nanoparticle platform, UCLA scientists say
2. Study shows hunger hitting closer to home
3. Chances of hurricane hitting Texas discussed at UH conference
4. How your body clock avoids hitting the snooze button
5. Why the swamp sparrow is hitting the high notes
6. NASA satellite gallery shows Chilean volcano plume moving around the world
7. Improve crop yield by removing manure solids
8. Death in the bat caves: UC Davis experts call for action against fast-moving disease
9. Algae for biofuels: Moving from promise to reality, but how fast?
10. New way of removing excess nitrogen from the environment
11. Succimer found ineffective for removing mercury
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... VIEW, Calif. , Dec. 18, 2014  23andMe, ... publication of a study that pinpoints fine-scale differences in ... United States . Since immigrants first ... the United States has served as a ... illuminates how American history and the ongoing mixing of ...
(Date:12/17/2014)... , Dec. 15, 2014 The Defense ... it easier to detect and prevent counterfeit microcircuits ... Today the agency started performing an in-house microcircuit ... validate the authenticity of purchased microcircuits while increasing ... quality control measures will be conducted at DLA,s ...
(Date:12/17/2014)... 16, 2014 Research and Markets ... the "Global Chemical Sensor Market 2015-2019" ... http://photos.prnewswire.com/prnh/20130307/600769 One major trend ... for medical sensors in biomedical applications. Chemical sensors ... and correct diagnosis during surgical procedures. The Global ...
Breaking Biology News(10 mins):23andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2
... But in a new disease-fighting role. Viruses that infect and ... era a century ago and in the former Soviet Union ... of the sticky "biofilms" of bacteria responsible for infections on ... the ACS journal Biomacromolecules . Marek Urban and ...
... FRANCISCO , May 8, 2013 Many people are ... treating eye conditions, but few may be aware of the ... the spotlight this month when Leonard Flom ... , M.D. (1926-2007), were inducted into the United States Patent ...
... On May 8 th JoVE will publish ... in bacteria. This new technology is a preliminary step in ... has led to more deaths than AIDS in the United ... of collaboration between Dr. Vitaly Vodyanoy at Auburn University and ...
Cached Biology News:Ophthalmologist Inventors of Human Identification Technology Inducted into National Inventors Hall of Fame 2Ophthalmologist Inventors of Human Identification Technology Inducted into National Inventors Hall of Fame 3Biosensor that detects antibiotic resistance brings us one step closer to fighting superbugs 2
(Date:12/19/2014)... LayerBio is an MIT spin-off developing novel drug ... Eye Institute (NEI) at the National Institutes of Health ... to develop a drug-eluting intraocular lens (IOL) for cataract ... vision loss in people over age 40 and the ... Mandell, LayerBio’s Founder and CEO, "There is a critical ...
(Date:12/19/2014)... 18, 2014 iLab Solutions, the global ... of Siri Bryant as the new Director of Institutional ... Core Implementations. These two new leadership positions were created ... by ensuring that iLab continues to meet the needs ... four years, iLab has been deployed at over 450 ...
(Date:12/19/2014)... (PRWEB) December 18, 2014 With only ... time special on Sartorius Biohit products . The ... mLINE pipettes, Picus Electronic Pipette Trade-in Program, and free ... and Safety officers around the world. They are ideal ... Other features include:, ,     Full volume range ...
(Date:12/19/2014)... ISN has released its third annual U.S. ... series. With data aggregated from over eight billion U.S. ... online contractor management platform, ISNetworld, this three-part series provides ... The Contractor Performance Benchmarking ... in two industry specific volumes: Oil & Gas, ...
Breaking Biology Technology:LayerBio Awarded NIH Grant to Develop a Drug Delivery Device for Cataract Surgery 2iLab Solutions Announces Two New Leadership Positions to Meet the Needs of Its Growing Customer Base 2Major Pipette Distributor Pipette.com Announces Sartorius Year End Specials 2ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 2ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 3
... TSX: SHQ),the global specialty biopharmaceutical company, announces the release on,March 25, 2008, of ordinary shares ... Term Incentive Plan ("LTIP")., In accordance with the rules of the LTIP, the ... ... ...
... March 25 deCODE genetics,(Nasdaq: DCGN ) today ... deCODE,CEO Kari Stefansson,s presentation at BioCentury 2008 Future Leaders ... delivered at 1:30 PM ET / 5:30 GMT on,Thursday, ... Center,New York City. The webcast can be accessed through ...
... long is the menopausal,transition? New data suggest that it,s ... -- think. Clinicians often face challenges,determining if women will ... will last., To meet the needs of health ... have published two supplements dealing with,both the menopausal transition ...
Cached Biology Technology:Shire plc: Long Term Incentive Plan 2deCODE genetics to Webcast Presentation at 15th Annual Future Leaders in the Biotech Industry Conference 2Hot Information for Physicians Treating Vasomotor Symptoms During the Menopausal Transition 2
... This BioSafe room is configured ... testing and chemical analysis. Panels are ... are easy to wipe down and ... Unique double-wall panel design creates strong, ...
... chemical fumes, allowing safe indoor ... filters remove most organic contaminants. ... flow speed = 100 fpm ... air speed monitor, quick-release filter/blower ...
Sigmas E-TOXATE (Limulus Amebocyte Lysate) test kits are intended for the detection and semiquantitation,of endotoxins for research purposes....
... The Staccato Series of systems provide ... drug discovery , genomics, proteomics and drug ... three base configurations; Mini Workstation Series, Application ... Sciclone ELISA Station is a remarkably compact ...
Biology Products: