Navigation Links
Hitting moving RNA drug targets
Date:6/26/2011

these results because one of the biggest challenges in RNA-targeted drug discovery is to be able to identify compounds that bind a specific RNA target without binding other RNAs. The ability of netilmicin to specifically bind TAR provides proof of concept for this new technology," said Stelzer.

Further experiments showed that, for the six potential drug molecules, the method not only successfully predicted that they would bind to TAR, it also showed---with atomic-level accuracywhere on the RNA molecule each drug would bind.

Al-Hashimi then turned the six drug candidates over to David Markovitz, a professor of infectious diseases at the U-M Medical School, who tested them in cultured human T cells infected with HIV. The point of this experiment was to see if the drugs would prevent HIV from making copies of itself, an essential step in the disease process.

"Netilmicin did in fact inhibit HIV replication," Markovitz said. "This result demonstrates that using an NMR spectrometer and some computers we can discover drugs that target RNA and are active in human cells."

In addition to testing compounds in existing molecular libraries, the virtual screening technique can be used to explore the potential of new compounds that have not yet been synthesized, Al-Hashimi said. "This opens up a whole new frontier for exploring RNA as a drug target and finding new compounds that specifically target it."


'/>"/>

Contact: Nancy Ross-Flanigan
rossflan@umich.edu
734-647-1853
University of Michigan
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Hitting target in cancer fight now easier with new nanoparticle platform, UCLA scientists say
2. Study shows hunger hitting closer to home
3. Chances of hurricane hitting Texas discussed at UH conference
4. How your body clock avoids hitting the snooze button
5. Why the swamp sparrow is hitting the high notes
6. NASA satellite gallery shows Chilean volcano plume moving around the world
7. Improve crop yield by removing manure solids
8. Death in the bat caves: UC Davis experts call for action against fast-moving disease
9. Algae for biofuels: Moving from promise to reality, but how fast?
10. New way of removing excess nitrogen from the environment
11. Succimer found ineffective for removing mercury
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... health advocates, campaigns against trans-fats have largely succeeded ... taking aim at sugar for its potential contributions ... are still wrangling over the best way to ... an article in Chemical & Engineering News ... American Chemical Society. , In the article, Stephen ...
(Date:8/27/2014)... that piglets can be weaned later with no negative ... the study at the University,s Roseworthy campus, published in ... important finding for pig producers. It allows improvements in ... "Sows don,t usually start their oestrous cycles again during ... been weaned," says Ms Alice Weaver, PhD candidate with ...
(Date:8/27/2014)... of Warwick research finds , Gamblers show the ... new research has shown. , Researchers, led by Dr ... Psychology, conducted tests that found that both human gamblers ... high-value than low-value rewards. , Published in Biology ... show the important role that memories of previous biggest ...
Breaking Biology News(10 mins):Piglet weaning age no bar to litter frequency 2Gamblers are greedy bird-brains, University of Warwick research finds 2
... Calif. ( http://www.ucr.edu ) A University of ... a group of researchers that have made important ... oscillator, which could serve as a timekeeping device ... assistant professor of mechanical engineering at UC Riverside,s ...
... Wistar Institute have developed a mathematical method for classifying ... brain cancer, through variations in the way these tumor ... predicting the subclasses of glioblastoma tumors with 92 ... physicians to accurately predict which forms of therapy would ...
... Are you active at your job? If you,re like most ... A team of researchers at the University of Iowa ... on movement. Yet the group found that police officers burn ... holding a baby or washing dishes. "We find that ...
Cached Biology News:Artificial cells and salad dressing 2Wistar scientists develop gene test to accurately classify brain tumors 2Wistar scientists develop gene test to accurately classify brain tumors 3Workers, get up and move 2Workers, get up and move 3
(Date:8/27/2014)... Boca Raton, FL (PRWEB) August 27, 2014 ... that are applied through the use of a handheld ... consumers across the United States. , The brand ... care unit. BIOEQUA researchers were surprised to learn that ... to be made extremely small and delivered directly to ...
(Date:8/27/2014)... WriteResult, LLC – a premier provider ... shown superiority when it comes to meeting the needs ... portion of their most recent study closeout on-time and ... WriteResult’s digital writing platform to collect Patient Reported Outcomes ... complete drew data from a number of assessments including ...
(Date:8/26/2014)... Bellingham, WA (PRWEB) August 26, 2014 ... visions for next-generation wearable technology, and inspiration for ... highlights at this year’s brighter, busier SPIE ... California, Convention Center. More than 4,400 international scientists, ... conferences, courses, an exhibition, and industry sessions sponsored ...
(Date:8/26/2014)... has just been added to the growing case ... the next big thing in the high-tech world ... An international collaboration of researchers led by a ... Lawrence Berkeley National Laboratory (Berkeley Lab) has reported ... in photo-excited MX2 materials. The recorded charge transfer ...
Breaking Biology Technology:BIOEQUA'S EQUA ESSENTIAL Product Line Redefines Skin Care & Now Available in America 2A Perfect Record: WriteResult Maintains a 100% On-Time ePRO Record with Latest Irritable Bowel (IBS) Study Data Lock 2Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 2Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 3Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 4Competition for graphene 2
... Laboratories , a leading single source provider of contract ... of analytical testing and ... testing is the perfect complement to our portfolio ... of Microtest Laboratories ( www.microtestlabs.com ). "By ...
... Orexigen(R) Therapeutics, Inc. (Nasdaq: OREX ), a biopharmaceutical company focused ... at the following meetings:, BIO 2009 Business Forum, ... a.m. - 9:35 a.m. Eastern, Location: Georgia World Congress ... Senior Vice President, Medical Affairs and, ...
... Transgenomic Inc. (OTC Bulletin Board: TBIO) announces the following Webcast: , ... Conference Call, ... Where: http://www.transgenomic.com/events.asp?id=6 , ... at, ...
Cached Biology Technology:Microtest Labs Adds Dissolution Testing to its Suite of Analytical and Stability Testing Services 2Microtest Labs Adds Dissolution Testing to its Suite of Analytical and Stability Testing Services 3Reminder: Transgenomic Inc. Announces First Quarter 2009 Earnings Release Conference Call Webcast 2
Agarose-LE, 500 g. Suitable for soft agarose cloning. Nuclease-free.Gel point (1.5%): 36 1.5 C, EEO (-mr): 1200 g/cm2. Category: Nucleotides & Enzymes & Biochemicals, Ultrapure Biochemicals ....
Request Info...
Request Info...
Limit of detection: <5 pg/ml...
Biology Products: