Navigation Links
Free online toolkit provides standard measures for genome and population studies
Date:4/20/2009

The National Human Genome Research Institute (NHGRI), part of the National Institutes of Health, today announced the release of the first version of a free online toolkit aimed at standardizing measurements of research subjects' physical characteristics and environmental exposures. The tools will give researchers more power to compare data from multiple studies, accelerating efforts to understand the complex genetic and environmental factors that cause cancer, heart disease, depression and other common diseases.

The toolkit, which is available at https://www.phenxtoolkit.org/, is the first product of the Consensus Measures for Phenotypes and eXposures (PhenX) initiative. Supported by a $6.8 million cooperative agreement from NHGRI and conducted by RTI International in Research Triangle Park, N.C., PhenX is a three-year project to develop a set of standard measures across 20 research categories related to health and common diseases.

"The PhenX toolkit will allow researchers to more easily combine and compare results across a wide range of studies, strengthening our efforts to untangle the complex genetic and environmental roots of common diseases," said Alan E. Guttmacher, M.D., acting director of NHGRI.

Cross-study comparisons can help researchers to refine estimates of disease risk, as well as to extend the findings of one study to other population groups.

Theoretically, by comparing studies that utilize the standard measures in the PhenX toolkit, researchers could more easily combine the results for each measurement from an obesity study with the results from a diabetes study to examine the overlap of genetic factors in the two health conditions.

"We encourage researchers to begin including the measures from the PhenX toolkit in new and existing studies now, so that they are familiar with the process and can add additional measures seamlessly to their research in the future," said Erin Ramos, Ph.D., an epidemiologist in NHGRI's Office of Population Genomics and an NIH project scientist with the PhenX project.

The first release of the PhenX toolkit contains standard measures selected by experts in three categories. They include demographics, with information on measurements such as current age, ethnicity, gender and current educational attainment; anthropometrics, or measurements of the human body and its proportions such as height, weight and waist circumference; and alcohol, tobacco and other substances, with measures such as alcohol maximum drinks in 24 hours , and nicotine dependence.

In addition to measures under each category, the toolkit includes information about each measure such as the rationale for its selection, standard data collection protocols, and a summary of research personnel and required training. Other categories of measures such as cardiovascular, nutrition, and dietary supplements, will be added in the next several months. The process used to develop the measures is being driven by the scientific community through the PhenX steering committee, working groups and surveys.

Researchers using the toolkit will soon have an option to register on the secure PhenX Web site. Researchers who choose to register will be given a password-protected account that allows them to save the measures they select for their studies. In the long term, the PhenX Web site has plans to develop a social networking platform that will allow registered researchers to interact and foster collaborations with other researchers.

Additional categories and measures will be added to the PhenX toolkit over the next few months. Along with its goal of listing 20 standardized measures, the toolkit will include supplemental information about each measure, such as current scientific thinking about its significance and influences upon health status. The process used to develop the measures is being driven by the scientific community through the PhenX steering committee, working groups and surveys.


'/>"/>

Contact: Geoff Spencer
spencerg@mail.nih.gov
301-402-0911
NIH/National Human Genome Research Institute
Source:Eurekalert

Related biology news :

1. UF to auction naming rights for new butterfly species online
2. Nonlinear ecosystem response points to environmental solutions
3. Yale Environment 360 magazine launches online
4. American Physical Society announces Physics, a new, free, online publication
5. TGen spin-off MedTrust Online enables cancer doctors to quickly obtain best-available information
6. Personalized medicine: Innovative online journal leads the way
7. Latin American Science Initiative Puts Tropical Rainforest Diversity Online
8. Smithsonian puts tropical Eastern-Pacific shore fishes online
9. Smithsonian puts tropical eastern Pacific shore fishes online
10. Powerful online tool for protein analysis provided pro bono by Stanford geneticist
11. New online report on massive jellyfish swarms released
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2016)... 2016   The Weather Company , an IBM Business ... industry-first capability in which consumers will be able to interact ... questions via voice or text and receive relevant information about ... Marketers have long sought an advertising solution that can ... personal, relevant and valuable; and can scale across millions of ...
(Date:5/16/2016)... 2016   EyeLock LLC , a market leader ... of an IoT Center of Excellence in ... development of embedded iris biometric applications. EyeLock,s ... and security with unmatched biometric accuracy, making it the ... DNA. EyeLock,s platform uses video technology to deliver a ...
(Date:4/28/2016)... First quarter 2016:   , Revenues amounted to ... of 2015 The gross margin was 49% (27) ... operating margin was 40% (-13) Earnings per share rose ... was SEK 249.9 M (21.2) , Outlook   ... The operating margin for 2016 is estimated to exceed ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June, 23, 2016  The Biodesign Challenge (BDC), ... new ways to harness living systems and biotechnology, announced ... (MoMA) in New York City . ... participating students, showcased projects at MoMA,s Celeste Bartos Theater ... Antonelli , MoMA,s senior curator of architecture and design, ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... announced the launch of the Supplyframe Design Lab . Located in Pasadena, ... explore the future of how hardware projects are designed, built and brought to ...
(Date:6/23/2016)... ... ... In a new case report published today in STEM CELLS Translational Medicine, doctors ... being treated for breast cancer benefitted from an injection of stem cells derived from ... frequent side effect of cancer treatment. , Lymphedema refers to the swelling ...
(Date:6/23/2016)... , June 23, 2016  Blueprint Bio, a ... discoveries to the medical community, has closed its Series ... Matthew Nunez . "We have received a ... the capital we need to meet our current goals," ... provide us the runway to complete validation on the ...
Breaking Biology Technology: