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£6.5M in funding to help manufacture the drugs of the future
Date:2/5/2013

e potential of stem cell therapies can be realised.

  • Linking recombinant gene sequence to protein product manufacturability using CHO cell genomic resources. University of Sheffield.
    • Bioinformatics and mathematics will be used to assess how efficiently mammalian cells can be used to harvest proteins manufacture specific proteins. This information will be used to create "design rules" that genetic engineers and cell factory developers can employ to design the most effective genetic code for a given protein product, and predict how much the mammalian cell factory can make.

  • Development of an integrated continuous process for recombinant protein production using Pichia pastoris. University of Cambridge.
    • Building on previous BRIC funding, the research will investigate an efficient way to ensure continuous target protein production in the yeast Pichia pastoris.

  • Development of new-generation bacterial secretion process platforms. University of Warwick.
    • Research will investigate a pathway to export target proteins manufactured in bacteria such as E. coli which offers potential for exporting proteins that the other pathways cannot support, and enable refinement of products of particularly high quality.

  • Commercial scale manufacture of adult allogeneic cell therapy University College London.
    • Universal cell lines of olfactory ensheathing cells will be cultured and assessed for regeneration potential.

  • Improving biopharmaceutical production in microbial systems: engineering GlycoPEGylation in E. coli. University of Sheffield.
    • Researchers will aim to produce an example therapeutic protein in the bacterium E. coli that can be purified and efficiently modified to improve its biological and physical characteristics and thus overall effectiveness.

  • Bioprocessing of high concentration protein solutions: quality by digital design
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  • Contact: Chris Melvin
    press.office@bbsrc.ac.uk
    44-179-341-4694
    Biotechnology and Biological Sciences Research Council
    Source:Eurekalert

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