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£6.5M in funding to help manufacture the drugs of the future
Date:2/5/2013

of Attenuated Total Reflectance-Fourier Transform Infrared (ATR-FTIR) spectroscopy will allow researchers to investigate the most effective techniques to isolate biopharmaceuticals during production processes.

  • Investigation of optimal gel conditions for stem cell preservation at room temperature and scaling up of selected methodology. University of Reading.
    • Research building on previous BRIC-funded work into using semi-permeable hydrogels to viably transport living biologic material at room temperature.

  • Multi-modal fluorescence spectroscopy for online analysis of proteins in bioprocesses. University College London.
    • This technique has potential to offer a sophisticated way of sensitively monitoring the purity of harvested proteins in real time.

  • Application of single cell metabolite profiling to optimisation of stem cell bioprocessing. The University of Manchester.
    • This work will seek to take "fingerprints" of the metabolism of individual stem cells, to relate each "fingerprint" with the controlling events that determine whether a cell becomes nerve, liver or pancreas cell for example. The information will help identify processes for maintenance of types of cells and to select for cells with a particular functional state.

  • Development of nanopatterned substrates for the delivery of high quality stem cells. University of Glasgow.
    • Developing previous work demonstrating stem cells can be cultured on a nanopatterned surface and retain their regenerative potential, researchers will grow stem cells on 1,000 different patterns to investigate their ability to influence the fate of the stem cells.

  • Expansion of human mesenchymal stem cells in aqueous / aqueous two phase systems. Loughborough University.
    • Combining the expertise of biologists and engineers to create scalable systems for the "manufacture" of large numbers of stem cells so th
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    Contact: Chris Melvin
    press.office@bbsrc.ac.uk
    44-179-341-4694
    Biotechnology and Biological Sciences Research Council
    Source:Eurekalert

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