Navigation Links
£2 million study to reveal workings of dementia genes
Date:9/23/2008

University of Manchester scientists are to investigate the biological causes of the second most common form of dementia after Alzheimer's, thanks to a prestigious 1.9 million senior fellowship award from the Medical Research Council.

Frontotemporal lobar degeneration (FTLD) is a group of dementias that affect the frontal and temporal lobes of the brain and are characterised by behaviour and language dysfunction, rather than the memory loss associated with Alzheimer's disease (AD).

FTLD, which affects about 50,000 people in the UK, also differs from AD in that it targets younger people: FTLD sufferers are usually in their 50s or 60s, although people as young as their 20s have also fallen victim to FTLD. AD sufferers tend to be older.

"Alzheimer's patients lose their awareness of space and time, whereas FTLD can result in changes in personality as well as speech and language difficulties," said Dr Stuart Pickering-Brown, who is leading the research.

"Sufferers can become apathetic or exhibit behaviour at the other extreme and lose normal social values which lead them to act inappropriately.

"Speech and language difficulties fall into two main types: sufferers can develop problems with grammar and pronunciation or have semantic dementia where they lose the information content of language.

Errors in two genes tau and progranulin have been identified as causes for FTLD but these only account for 10% of cases. The University of Manchester team plan to investigate the role other genes may play in the disease.

"Our research suggests other genes may be important in regulating the amount of tau and progranulin in the brain," said Dr Pickering-Brown, who is based in the School of Translational Medicine.

"Progranulin is associated with wound healing and little is known about its function in the brain, so we now plan to study the effects of progranulin on cells and explore how it is affected by other genes."

At the end of the five year study, the team hope to have a much clearer understanding of the genetic causes underlying FTLD.

"Understanding the biological problems that lead to FTLD will help in diagnosing the condition and ultimately allow us to find future therapies for patients."


'/>"/>

Contact: aeron.haworth@manchester.ac.uk
aeron.haworth@manchester.ac.uk
44-161-275-8383
University of Manchester
Source:Eurekalert

Related biology news :

1. Structure of 450 million year old protein reveals evolutions steps
2. First orchid fossil puts showy blooms at some 80 million years old
3. SyntheMed Completes $2.8 Million Equity Financing
4. Rutgers Genetics receives $7.8 million for autism research
5. Seattle Childrens Hospital leads $23.7 million NIH grant to study gene repair
6. UD leads $5.3-million research project on rice epigenetics
7. Rutgers high school outreach gets $3 million boost from NSF
8. NIH awards researcher $1.5 million new innovator grant for fruit-fly studies of prion proteins
9. UD leads $5.3-million research project on rice epigenetics
10. $22 million gift from Alfred Taubman launches new biomedical research institute
11. Nanobiosym awarded $2 million DTRA contract
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/16/2016)... The global Biometric ... USD 1.83 billion by 2024, according to a ... proliferation and increasing demand in commercial buildings, consumer ... the market growth.      (Logo: ... of advanced multimodal techniques for biometric authentication and ...
(Date:6/9/2016)... Paris Police Prefecture and ... ensure the safety of people and operations in several locations ... Teleste, an international technology group specialised in broadband ... its video security solution will be utilised by ... across the country. The system roll-out is scheduled for the ...
(Date:6/2/2016)... , June 2, 2016 The Department ... has awarded the 44 million US Dollar project, for the ... Vehicle Plates including Personalization, Enrolment, and IT Infrastructure , ... in the production and implementation of Identity Management Solutions. Numerous ... however Decatur was selected for the ...
Breaking Biology News(10 mins):
(Date:12/4/2016)... Mass. and CAMBRIDGE, Mass. ... Africa , Dec. 4, 2016 ... providing connected diagnostics software platforms for the developing ... making "Anywhere. Care.™" a reality with its portable ... have entered into a development and license agreement ...
(Date:12/2/2016)... 2, 2016 More than $4.3 million was raised ... ( DHMD ). The gala was held at the American ... City and honored Alan Alda and ... health and medicine and the public understanding of science. Since ... the event has raised $40 million for the Laboratory,s research ...
(Date:12/2/2016)... , Dec. 2, 2016 Amgen (NASDAQ: ... ) today announced the submission of a Marketing Authorization Application ... a biosimilar candidate to Avastin ® (bevacizumab). The companies ... to the EMA. "The submission of ABP ... seeks to expand our oncology portfolio," said Sean E. ...
(Date:12/2/2016)... 2, 2016 Research and Markets has ... Applications, Markets and Companies" to their offering. ... , , ... pharmaceutical and biotechnology industries is anticipated. Nanotechnology will be applied ... optimal delivery to diagnostic applications in clinical trials. Many of ...
Breaking Biology Technology: