Navigation Links
$7 million grant designates Nationwide Children's as Wellstone Center
Date:8/26/2010

A $7 million grant from the National Institutes of Health (NIH) will help researchers at Nationwide Children's Hospital translate new scientific findings and technological developments into novel treatments for the muscular dystrophies. The grant designates Nationwide Children's Hospital as a Paul D. Wellstone Muscular Dystrophy Cooperative Research Center, one of three national award recipients in 2010.

The award explores and refines therapeutic strategies that have shown promise in animal models of muscular dystrophy. Studies include further research in the laboratory as well as clinical trials to assess efficacy in patients. These efforts include replacing defective genes responsible for muscular dystrophy with healthy ones. Other trials use substitute or surrogate genes to restore muscle function. A third approach attempts to repair gene function using specially designed medications. All the studies aim to slow the progression of muscular dystrophy.

In 2001, the United States MD-CARE Act specified a number of provisions for expanding and intensifying research on muscular dystrophy, notably the NIH's establishment of centers of excellence for research on these muscle diseases. The Muscular Dystrophy Cooperative Research Centers (MDCRCs) program was subsequently developed in honor of Senator Paul D. Wellstone, a champion of muscular dystrophy research. MDCRCs promote basic, translational and clinical research and provide important resources that can be shared within the national muscle biology and neuromuscular research communities. The MDCRCs also serve as focal points for research collaborations and provide training and guidance for basic and clinical researchers.

The MDCRC will allow Nationwide Children's researchers to further develop methods to overcome immune barriers to gene correction for Duchenne muscular dystrophy (DMD). Jerry Mendell, MD, director, Center for Gene Therapy and Chris Walker, PhD, director, Center for Vaccine and Immunity, are co-leaders for the new center.

"Nationwide Children's has been built an impressive history of innovative research and scientific collaboration with the goal of curing muscular dystrophies," said Dr. Mendell. Within the past five years, researchers in the Center for Gene Therapy and Center for Vaccine and Immunity have been awarded multi-million-dollar grants from the NIH, and published key articles in high-impact journals such as Cell, the Proceedings of the National Academy of Sciences and Nature. The Muscular Dystrophy Association (MDA) named Nationwide Children's Hospital to its Clinical Research Network in 2008. "The designation as a Wellstone Center reiterates that we're moving in the right direction," said Dr. Mendell.

"Receiving this grant and designation as a Wellstone Center a prestigious national validation of the groundbreaking muscular dystrophy research being performed by our neurosciences group establishes Nationwide Children's as a national leader in neuromuscular research and treatment," said John Barnard, MD, president of The Research Institute at Nationwide Children's Hospital. "I am especially pleased that a major strength of our research program is it multidisciplinary nature, including intensive collaborations with colleagues in the Center for Vaccines and Immunity here at The Research Institute and in various departments on The Ohio State University's main campus."


'/>"/>

Contact: Erin Pope
Erin.Pope@NationwideChildrens.org
614-355-0495
Nationwide Children's Hospital
Source:Eurekalert

Related biology news :

1. £2 million study to reveal workings of dementia genes
2. NIH awards Clemson bioengineer $1.5 million to improve durability of tissue heart valves
3. L-1 Identity Solutions Receives $5.9 Million Drivers License Contract Expansion from the State of Mississippi
4. L-1 Identity Solutions Awarded New Massachusetts RMV Drivers License Contract Valued at an Estimated $32 Million
5. FSU researchers discovery leads to $1.5 million grant, potential new treatment of liver fibrosis
6. Missouri Botanical Garden mounts milestone 6 millionth herbarium specimen
7. New $11 million center to speed production of new compounds for drug discovery
8. SAIC Awarded $37 Million Contract to Support U.S. Army Program Executive Office - Enterprise Information Systems
9. Eastman Dental Center awarded $1.6 million to find ways to prevent cavities
10. L-1 Identity Solutions Selected by the State of New York as the Winning Bidder to Provide Enrollment Services for a Contract Estimated at Up to $250 Million
11. Deep heat solution to 500-million year mystery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/9/2016)... leader in attendance control systems is proud to announce the introduction of fingerprint attendance ... the right employees are actually signing in, and to even control the opening of ... ... ... Photo - ...
(Date:6/3/2016)... , June 3, 2016 ... Management) von Nepal ... und Lieferung hochsicherer geprägter Kennzeichen, einschließlich Personalisierung, ... führend in der Produktion und Implementierung von ... der Ausschreibung im Januar teilgenommen, aber Decatur ...
(Date:6/2/2016)... LONDON , June 2, 2016 ... Systems, Manned Platforms, Unmanned Systems, Physical Infrastructure, Support & ... intelligence provider visiongain offers comprehensive analysis of ... that this market will generate revenues of $17.98 billion ... Systems acquired DVTEL Inc, a leader in software and ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... 2016   Boston Biomedical , an industry ... to target cancer stemness pathways, announced that its ... Drug Designation from the U.S. Food and Drug ... including gastroesophageal junction (GEJ) cancer. Napabucasin is an ... cancer stemness pathways by targeting STAT3, and is ...
(Date:6/23/2016)... ... June 23, 2016 , ... Charm Sciences, Inc. is pleased ... received AOAC Research Institute approval 061601. , “This is another AOAC-RI approval of ... Salter, Vice President of Regulatory and Industrial Affairs. “The Peel Plate methods perform ...
(Date:6/23/2016)... ... 23, 2016 , ... Supplyframe, the Industry Network for electronics ... Lab . Located in Pasadena, Calif., the Design Lab’s mission is to bring ... designed, built and brought to market. , The Design Lab is Supplyframe’s physical ...
(Date:6/23/2016)... Calif. , June 23, 2016  Blueprint Bio, ... biological discoveries to the medical community, has closed its ... Matthew Nunez . "We have received ... with the capital we need to meet our current ... essentially provide us the runway to complete validation on ...
Breaking Biology Technology: