Navigation Links
$7.5 million to JAX from South Korean government for cancer genomics project
Date:1/22/2014

The Jackson Laboratory, in collaboration with Seoul National University, will receive a five-year, $7.5 million grant from the South Korean government for a large-scale cancer genomics project employing the latest sequencing technology and special JAX mouse models that can host human tumors.

"This is a wonderful example of the international collaborations that JAX is building to rapidly advance its research mission, in this case: individualized cancer diagnosis and treatment," said Charles Lee, Ph.D., director of The Jackson Laboratory for Genomic Medicine and leader of the JAX component of the project,

Lee, who is also a distinguished visiting professor at Seoul National University, will work with principal investigator Jong-Il Kim, M.D., Ph.D., of the Seoul National University College of Medicine and other academic collaborators in Seoul.

During the first phase of the grant (2013-15), Kim and colleagues will collect and store tumors from patients with gastric, breast, colon, lung and rare cancers, and sequence and determine the genomic signatures of those cancers.

Lee will lead the development of hundreds of new mouse model systems for gastric, breast and other cancers that will be made available to the worldwide scientific community. The so-called PDX models (for patient-derived xenograft) represent mice that carry human tumors, enabling detailed functional study of the cellular and genomic characteristics of specific cancers.

The research team will also build a publicly accessible library of anticancer drugs and establish a drug efficacy screening system using patient-derived primary cell lines and PDX mouse models.

Lee explains that the researchers expect to find genetic similarities among certain cancers. "If we look at 1,000 gastric cancers, their genetic signatures may group into, say, 20 clusters. We can then do preclinical testing on just a few tumors from each of those groups, testing different drugs or combinations of drugs to determine which therapies are most effective for treating those tumors with a given genetic signature."

During the grant's second phase (2016-17), the researchers will take the project to the clinic, developing a personalized anticancer drug screening system and establishing a clinical trial network for individualized medicinal screening.

"This grant from the South Korean government shows there's international interest in The Jackson Laboratory's approach to cancer research using PDX models," Lee says.


'/>"/>

Contact: Joyce Peterson
joyce.peterson@jax.org
207-288-6058
Jackson Laboratory
Source:Eurekalert

Related biology news :

1. Dartmouth-led team gets $8 million grant to research arsenic in children
2. With $1.6 million award, biochemist tackles diabetes
3. Autism Speaks awards nearly $2.7 million for new research projects
4. After a 49-million-year hiatus, a cockroach reappears in North America
5. Physicians awarded $4 million to study effects of fertility treatments and obstetric care
6. Algae to crude oil: Million-year natural process takes minutes in the lab
7. UT Dallas awarded $1 million to improve prosthetics for soldiers
8. Pitt-led network gets $70 million over 7 years to develop, test HIV prevention products
9. A new species of horse, 4.4 million years old
10. EPA awards $1 million grant to NJITs Brownfield program
11. Army renews bio-inspired engineering and science research center at UC Santa Barbara with $48 million
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/14/2016)... -- NXTD ) ("NXT-ID" or the "Company"), a ... airing of a new series of commercials on Time Warner ... st .  The commercials will air on Bloomberg TV, Fox ... Street show. --> NXTD ) ("NXT-ID" or the ... announces the airing of a new series of commercials on ...
(Date:3/10/2016)... India , March 10, 2016 ... a new market research report "Identity and Access Management ... & Audit, Compliance, and Governance), by Organization Size, by ... to 2020", published by MarketsandMarkets, The market is estimated ... USD 12.78 Billion by 2020, at a Compound Annual ...
(Date:3/9/2016)... , March 9, 2016  Crossmatch ® ... and enrollment solutions, today announced the addition of ... Altus multi-factor authentication platform. New contextual ... managers to step-up security where it,s needed most ... Washington, DC . --> ...
Breaking Biology News(10 mins):
(Date:4/28/2016)... Hill, Conn. (PRWEB) , ... April 28, 2016 ... ... of financing and ongoing support for Connecticut's innovative, growing companies, today announced the ... digital health and financial technology (fintech) companies. , “VentureClash looks to ...
(Date:4/28/2016)... ... April 28, 2016 , ... As part of an ongoing ... and expanding its LATAM network and logistics capabilities. Enhancements have been made ... clinical trial projects. , The expansion will provide unmatched clinical trial logistics services ...
(Date:4/27/2016)... ... 2016 , ... Cambridge Semantics, the leading provider of Smart Data ... has been named to The Silicon Review’s “20 Fastest Growing Big Data Companies of ... serves the needs of end users facing some of the most complex data challenges ...
(Date:4/27/2016)... ... April 27, 2016 , ... The Pittcon Organizing Committee is pleased to announce ... a volunteer member of Committee since 1987. Since then, he has served in a ... and was chairman for both the program and exposition committees. In his professional career, ...
Breaking Biology Technology: