Navigation Links
$3.75 million grant advances tissue engineering partnership
Date:1/27/2010

CINCINNATIAn award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) will aid a partnership between the University of Cincinnati (UC) and Cincinnati Children's Hospital Medical Center (CCHMC) in finding new ways to use adult stem cells to speed repair of musculoskeletal soft tissue injuries.

The five-year grant is for $3.75 million and involves collaboration between UC's Department of Biomedical Engineering and the Division of Developmental Biology at CCHMC.

David Butler, PhD, UC professor of biomedical engineering, says the award is designated as a Bioengineering Research Partnership (BRP) to support a multidisciplinary research team applying an integrative approach to solving a major biomedical problem.

For more than a decade, Butler's lab has focused on developing better repairs for the patellar tendon, the site where surgeons harvest tissue when reconstructing a torn anterior cruciate ligament (ACL).

Because surgeons remove about a third of the tendon for the ACL, the site remains a problem for many patients. It also could be a source of another graft if the site could be repaired.

"A lot of times patients say their pain doesn't come from the ACL graft, but from the donor site where the graft was harvested," says Butler. "So that motivated us to look at tendon repair and tendon healing, and to use this model to investigate tissue engineering principles and ways in which we can more effectively repair any damaged tendon."

Butler and his team have previously used a paradigm they developed called Functional Tissue Engineering (FTE) where researchers first study the normal structure and in vivo activity levels of tissues as they function within the body. By using the forces measured in the tendon during normal activity as design parameters, they can better evaluate the function of tissue engineered constructs, or TECs.

A combination of adult stem cells and biomaterials, TECs exhibit promise as a treatment after tendon injury. By mechanically stimulating TECs prior to surgery, Butler says UC researchers have created TECs that almost exactly match the functional stiffness of the normal tendon. But, he says, these TEC-based repairs can't completely recreate the exact tendon architecture, especially where it inserts into bone.

That led to the partnership between Butler's lab and the lab of Christopher Wylie, PhD, professor and director of the division of developmental biology at CCHMC.

"We want to understand how the tendon normally develops," says Butler, "because we might then be able to introduce or precondition these TECs biologically in a way that's even more effective than what we've done using mechanical stimulation. We actually hope to introduce some of these signals that we measure during growth and development during the repair process that occurs after injury in the adult tendon."

Using multi-functional tissue engineering, Butler and Wylie will identify which genes and signaling pathways are expressed at different stages of normal tendon development.

Then, they will work to experimentally manipulate the expression of those target genes and signals in TECs prior to introducing them at surgery.

They hope that the research will not only lead to better TECs for soft tissue repair, but a maturation of tissue engineering principles that can be applied for bone or cartilage repair.

In order to share those principles, Butler and Wylie will present their work to a consortium of clinical and basic science investigators as well as an industry panel at a one-day conference at UC in April.

"These BRPs are not about just doing fundamental research," Butler says, "they're about translating that research to more rapidly bring treatments to patients."


'/>"/>

Contact: Katy Cosse
kathryn.cosse@uc.edu
513-558-0207
University of Cincinnati Academic Health Center
Source:Eurekalert

Related biology news :

1. T. Denny Sanford donates $50 million to Burnham Institute for Medical Research
2. Duke awarded up to $43 million to develop test for dirty bomb/radiation exposure
3. UF gets almost $15 million in federal funds to build research complex to help older adults
4. Molecular Biometrics Closes $12.5 Million Series B Equity Funding
5. $1 million from NIH continues cell growth regulation studies
6. Brandeis wins $1 million Keck Foundation grant to research active matter
7. LSUHSC awarded multi-million dollar grant to reduce pneumonia
8. University of Maryland School of Medicine receives $30 million to coordinate stem cell consortium
9. Story of 4.5 million-year-old whale unveiled in Huelva
10. NTU and EDB launch S$50 million ($36 million) integrated circuit design research center
11. Penn, Georgia collaboration awarded $14.6 million to expand pathogen database
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... SAN FRANCISCO and BANGALORE, India ... part of EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... service provider, today announced a global partnership that ... convenient way to use mobile banking and payment services. ... Mobility is a key innovation area for financial services, but ...
(Date:4/19/2016)... DUBAI , UAE, April 20, 2016 ... can be implemented as a compact web-based "all-in-one" system ... in the biometric fingerprint reader or the door interface ... requirements of modern access control systems. The minimal dimensions ... the ID readers into the building installations offer considerable ...
(Date:4/13/2016)... physicians supporting Medicaid patients in Central Florida ... telehealth thanks to a new partnership with higi.   ... can routinely track key health measurements, such as blood ... they opt in, share them with IMPOWER clinicians through ... location at no cost. By leveraging this data, IMPOWER ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... LOUISVILLE, Ky. , June 23, 2016 /PRNewswire/ ... from two Phase 1 clinical trials of its ... double-blind, placebo-controlled, single and multiple ascending dose studies ... and pharmacodynamics (PD) of subcutaneous injection in healthy ... APL-2 subcutaneously (SC) either as a single dose ...
(Date:6/23/2016)... -- Andrew D Zelenetz , ... Published recently in Oncology & ... Andrew D Zelenetz , discusses the fact ... placing an increasing burden on healthcare systems worldwide, ... the patents on many biologics expiring, interest in ...
(Date:6/23/2016)... Francisco, CA (PRWEB) , ... June 23, 2016 ... ... (EDC) software, is exhibiting at the Pennsylvania Convention Center and will showcase its ... Annual conference. ClinCapture will also be presenting a scientific poster on Disrupting Clinical ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... line of intelligent tools designed, tuned and optimized exclusively for Okuma CNC machining ... Chicago. The result of a collaboration among several companies with expertise in toolholding, ...
Breaking Biology Technology: