Navigation Links
$22.5 million grant funds international study of membrane proteins
Date:8/10/2010

The outer surface of cells is a factory floor of machines with varied functions: exchanging materials in and out, receiving signals, and generating energy. Studying these machines, called membrane proteins, is one of the greatest challenges of science, crucial for understanding cellular biology and developing new drugs to fight disease.

One of the largest and most comprehensive collaborations to understand the structure and dynamic function of membrane proteins was officially launched Tuesday with a 5-year, $22.5 million grant from the National Institute of General Medical Sciences. The funding, known as a "glue grant," unites nearly 30 scientists from 14 institutions in 4 different countries into an effort called the Membrane Protein Structural Dynamics Consortium.

"We have been able to put together almost a dream team of people currently involved in this type of research," said Eduardo Perozo, PhD, Professor of Biochemistry and Molecular Biology at the University of Chicago Medical Center and the leader of the team. "There has been nothing like this project before."

Research on membrane proteins has traditionally been divided into two groups: structure and function. The new collaboration will focus on uniting those two areas through the study of dynamics, how a membrane protein changes shape and function over time.

To do so, the effort will unite experts across disciplines and knowledgeable in a wide range of cutting-edge technologies, including magnetic resonance and fluorescence spectroscopy, computational modeling, and electrophysiology. Core facilities for different techniques will be set up at institutions for shared use by all members of the consortium and eventually the scientific community at large.

Deeper knowledge of membrane protein dynamics will enable the development of better drugs for diseases involving defective channels and transporters, such as forms of heart disease, diabetes, and neurological and hormonal disorders. Understanding how membrane proteins allow molecules into and out of cells can also help improve drug design and delivery for an even wider range of diseases.

"We intend to start with targets for which we know the static structure at high resolutions and the function on a certain level, but don't know how they connect through dynamics," Perozo said. "Eventually, we want to develop a set of tools and reagents to be able to engineer or alter normal activity in these systems."


'/>"/>

Contact: Robert Mitchum
robert.mitchum@uchospitals.edu
773-702-6241
University of Chicago Medical Center
Source:Eurekalert

Related biology news :

1. NOAA awards $22.5 million to Harbor Branch/FAU and UNCW for new cooperative institute
2. £2 million study to reveal workings of dementia genes
3. NIH awards Clemson bioengineer $1.5 million to improve durability of tissue heart valves
4. L-1 Identity Solutions Receives $5.9 Million Drivers License Contract Expansion from the State of Mississippi
5. L-1 Identity Solutions Awarded New Massachusetts RMV Drivers License Contract Valued at an Estimated $32 Million
6. FSU researchers discovery leads to $1.5 million grant, potential new treatment of liver fibrosis
7. Missouri Botanical Garden mounts milestone 6 millionth herbarium specimen
8. New $11 million center to speed production of new compounds for drug discovery
9. SAIC Awarded $37 Million Contract to Support U.S. Army Program Executive Office - Enterprise Information Systems
10. Eastman Dental Center awarded $1.6 million to find ways to prevent cavities
11. L-1 Identity Solutions Selected by the State of New York as the Winning Bidder to Provide Enrollment Services for a Contract Estimated at Up to $250 Million
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2016)... 20, 2016 A market that just keeps ... from the explosion in genomics knowledge. Learn all about ... A range of dynamic trends are pushing market growth ... medicine - pharmacogenomics - pathogen evolution - next generation ... - greater understanding of the role of genetic material ...
(Date:1/15/2016)... Rico , Jan. 15, 2016 Recent ... and small to find new ways to ensure data ... iOS and Android that ... on biometrics, transforming it into a hardware authorization token. ... users swipe their fingerprint on their KodeKey enabled device ...
(Date:1/11/2016)... , Jan. 11, 2016  higi, the leading ... 10,000 retail locations, web and mobile, today announced ... million from existing investors. --> ... devoted to further innovate higi,s health platform – ... web portal – including expanding services and programs ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... ... February 11, 2016 , ... ... cell treatment clinic in Quito, Ecuador. The new facility will provide advanced protocols ... patients from around the world. , The new GSCG clinic is headed ...
(Date:2/10/2016)... 10, 2016  The Maryland House of Delegates and ... that University of Maryland School of Medicine Dean ... of Maryland Medical System President and CEO Robert ... the highest honor given to the public by the ... Dean Reece and Mr. Chrencik for their contributions ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... that it has joined the Human Vaccines Project, a public-private partnership to ... cancer. , The Human Vaccines Project brings together leading pharmaceutical and ...
(Date:2/10/2016)... 10, 2016  Matchbook, Inc., a company specializing ... biotech companies, announced today the appointment of ... Jim brings nearly 25 years of experience in ... spent nearly two decades in executive level roles ... at Genzyme and, most recently headed global logistics ...
Breaking Biology Technology: